ANTICONVULSANT ACTIVITY OF PORTULACA OLERACEA LINN. AND EUPATORIUM BRIMANICUM DC IN MES INDUCED SEIZURE: A COMPARATIVE STUDY

Authors

  • MAYANGLAMBAM MEDHABATI Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, India
  • LAISHRAM BABYCHA Department of Pharmacology, Jawaharlal Nehru Institute of Medical Sciences, Imphal, India
  • ABHISHEK BHATTACHARJEE Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, India
  • NGANGOM GUNINDRO Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, India

DOI:

https://doi.org/10.22159/ijcpr.2021v13i2.41561

Keywords:

MES, Anticonvulsant, Portulaca oleracea Linn, Eupatorium brimanicum DC, Albino mice

Abstract

Objective: The study was aimed to evaluate and compare the anticonvulsant activity of aqueous leave extract of Portulaca oleracea Linn. and Eupatorium brimanicum DC in MES model in albino mice.

Methods: Aqueous Extracts were prepared by the soxhlet extraction method. MES model was chosen to evaluate anticonvulsant activity. 36 albino mice were selected and divided into 6 groups for this model. Group I received 2% gum acacia 1 ml/100 g orally. Group II received phenytoin-20 mg/kg orally. Group III and IV received 200 and 400 mg/kg of Portulaca oleracea Linn. Respectively. Group V and VI received 200 and 400 mg/kg of Eupatorium brimanicum DC respectively.

Results: The extracts didn’t show any toxicity and significantly reduced hind limb tonic extension (HLTE) duration in MES model (50 mA, 0.2 sec) at higher doses.

Conclusion: The results suggest Portulaca oleracea Linn. and Eupatorium brimanicum DC extract possess anticonvulsant activity and justify their use in folk medicine.

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Published

2021-03-15

How to Cite

MEDHABATI, M., L. BABYCHA, A. BHATTACHARJEE, and . N. GUNINDRO. “ANTICONVULSANT ACTIVITY OF PORTULACA OLERACEA LINN. AND EUPATORIUM BRIMANICUM DC IN MES INDUCED SEIZURE: A COMPARATIVE STUDY”. International Journal of Current Pharmaceutical Research, vol. 13, no. 2, Mar. 2021, pp. 67-69, doi:10.22159/ijcpr.2021v13i2.41561.

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