ANTICONVULSANT ACTIVITY OF PORTULACA OLERACEA LINN. AND EUPATORIUM BRIMANICUM DC IN MES INDUCED SEIZURE: A COMPARATIVE STUDY
Keywords:MES, Anticonvulsant, Portulaca oleracea Linn, Eupatorium brimanicum DC, Albino mice
Objective: The study was aimed to evaluate and compare the anticonvulsant activity of aqueous leave extract of Portulaca oleracea Linn. and Eupatorium brimanicum DC in MES model in albino mice.
Methods: Aqueous Extracts were prepared by the soxhlet extraction method. MES model was chosen to evaluate anticonvulsant activity. 36 albino mice were selected and divided into 6 groups for this model. Group I received 2% gum acacia 1 ml/100 g orally. Group II received phenytoin-20 mg/kg orally. Group III and IV received 200 and 400 mg/kg of Portulaca oleracea Linn. Respectively. Group V and VI received 200 and 400 mg/kg of Eupatorium brimanicum DC respectively.
Results: The extracts didn’t show any toxicity and significantly reduced hind limb tonic extension (HLTE) duration in MES model (50 mA, 0.2 sec) at higher doses.
Conclusion: The results suggest Portulaca oleracea Linn. and Eupatorium brimanicum DC extract possess anticonvulsant activity and justify their use in folk medicine.
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