FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS
Keywords:Sustained release drug delivery, Matrix tablets, Diffusion, Rate limiting polymer, Anti-diabetic
Objective: Now a days as very few antidiabetic drugs are coming out of research and development and some existing drugs are showing several side effects when administered orally, multiple times in a day, hence change in the operation is a suitable and optimized way to make some drug more effective by slight alteration in the drug delivery. Matrix type drug delivery systems of an antidiabetic drug like Metformin Hydrochloride, is an interesting and promising option when developing an oral sustained release system
Methods: An appropriately designed controlled release drug delivery system can be a major advance towards solving problems concerning the targeting of a drug to a specific organ or tissue and controlling the rate of drug delivery to the target sites. This research work is made in designing of sustained release dosage form of Metformin Hydrochloride by wet granulation method employing both Xanthan Gum and Hydroxy Propyl Methyl Cellulose (HPMC K4M) as a rate controlling polymer.
Results: The development of oral sustained release systems has been a challenge to formulation scientists due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract. From all the formulation trial batches, formulation F7 shows the best results. It has been observed that HPMC K4M alone cannot give satisfactory drug release profile but the blend of HPMC K4M and Xanthan gum together give the best drug release kinetics.
Conclusion: The drug release mechanism from the matrix tablets follows Fickian diffusion with first order kinetics. Thus, sustained release matrix tablets of metformin hydrochloride can be expected to reduce the frequency of administration and decrease the dose dependent side effects
Brahmankar DM, Jaiswal SB. Biopharmaceutics and pharmacokinetics a treatise. 1st ed. New Delhi: Vallabh Prakashan; 1995.
Chein YW. Noval drug delivery systems. 2nd ed. New York: Marcel Dekker; 1992. p. 1-42.
Jain NK. CBS publishers and distributors. 1st ed. New Delhi: Pharmaceutical Product Development; 2006. p. 419-24.
Vyas SP, Khar RK. Controlled drug delivery concepts and advances. 1st ed. New Delhi: Vallabh Prakashan; 2010. p. 1-12.
Robinson JR, Lee VHL. Controlled drug delivery: fundamentals and applications. 2nd ed. New York: Marcel Dekker; 1987. p. 253-60.
Lalla JK. Introduction to controlled release and oral controlled drug delivery system. East Pharm. 1991;45:25-8.
Jantzen GM, Robinson JR. Morden pharmaceutics. 4th ed. New York: Marcel Dekker; 1996. p. 492-520.
Modi SA, Gaikwad PD, Bankar VH, Pawar SP. Sustained release drug delivery system: a review. Int J Pharm Res Dev. 2011;2(12):147-60.
Lieberman HA, Lachman L, Schwartz JB. Pharmaceutical dosage forms: tablets. 2nd ed. Vol. 3. p. 199-287.
Aulton ME. Pharmaceutics: the science of dosage form design. 2nd ed. Churchill Livingstone; 2005. p. 296-8.
Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral drug delivery- a review. Pharm Sci Technol Today. 2000;3(4):138-45. doi: 10.1016/s1461-5347(00)00247-9, PMID 10754543.
Mahesh Hemnani, Upendra Patel, Ghanshyam Patel, Dhiren Daslaniya, Amarish Shah, Bhavin Bhimani. Matrix tablets: a tool of controlled drug delivery. Am J Pharm Tech Res. 2011;1(4):127-43.
Bradoo R, Shahani S, Poojary S, Deewan B, Sudarshan S. Fast dissolving drug delivery systems. JAMA India. 2010;4:27-31.
Indian pharmacopoeia. Ghaziabad, New Delhi: government of India, Ministry of Health and Family Welfare; 2007.
Wise DL. Handbook of pharmaceutical controlled release technology. 1st ed. New York: Marcel Dekker, Inc; 2005. p. 5-24.
Kamboj S, Gupta GD. Matrix tablets: an important tool for oral controlled-release dosage forms. Pharm Rev. 2009;7(6);1.
Eswaraiah C, Jaya S. Formulation and in vitro evaluation of metformin hydrochloride sustained release tablets. J Drug Delivery Ther. 2019;9(4):24-9.
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