ULTRASOUND-ASSISTED MICROWAVE SYNTHESIS AND MECHANISTIC ASPECT OF 2-AMINO-4, 6-DIARYL PYRIMIDINES AND 3, 5-DIARYL-1H- PYRAZOLES


Amin O. Elzupir, Ahmed E. M. Saeed, Jan H. Van Der Westhuizen

Abstract


A novel approach have been developed for synthesis of a series of 2- amino 4,6- diaryl pyrimidines and 3,5-diaryl -1H- pyrazoles, using a condensation reaction of guanidine or hydrazine with enones compounds, in the presence of ethanol as solvent and NaOH as catalyst. Ultrasound was used for solvation of the enones, followed by microwave for heterocyclization reaction. A moderate to good yield has been gotten in a short period of time. The structures of synthetic compounds have been elucidated by 1H NMR, EI-MS, FT-IR and UV-Vis spectroscopy. Moreover, the mechanism of reaction was investigated, the products were formed through direct addition to hard electrophile followed by heterocyclization.

Keyword: Pyrimidine, Pyrazole, Sonochemistry, Microwave synthesis.

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About this article

Title

ULTRASOUND-ASSISTED MICROWAVE SYNTHESIS AND MECHANISTIC ASPECT OF 2-AMINO-4, 6-DIARYL PYRIMIDINES AND 3, 5-DIARYL-1H- PYRAZOLES

Date

06-01-2015

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 7, Issue 1, 2015 Page: 7-12

Online ISSN

0975-7066

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Authors & Affiliations

Amin O. Elzupir
Al Imam Mohammad Ibn Saud Islamic University, Committee on Radiation and Environmental Pollution Protection, Riyadh, Saudi Arabia.

Ahmed E. M. Saeed

Jan H. Van Der Westhuizen


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