REVIEW ON SIZE EXCLUSION CHROMATOGRAPHY COUPLED WITH MASS SPECTROSCOPY
DOI:
https://doi.org/10.22159/ijcpr.2025v17i1.6055Keywords:
Hyphenated techniques, SEC-MS, Polymer analysis by SEC-MS, On-line couplingAbstract
The hyphenated technique was created by integrating the differentiating technique with directly spectroscopic technology to facilitate detection. It is discussed how SEC and electrospray ionization mass spectrometry (ESI-MS) can be combined, emphasizing the advantages this has for characterizing polymers. The capacity of SEC-ESI-MS to gather polymer structural information as well as to confirm polymer homologous transitions is first described. It's significant that the broad applicability of SEC-ESI-MS is underlined, for instance by its usage in the analysis of precise molecular weight distribution of polymers, the calculation of radical rate of polymerization coefficients, and the thorough exploration of radical photoinitiation systems. Thus, this momentous tutorial review intends to highlight the high potential of SEC-ESI-MS to emerge as a formidable and well-liked analytical method in polymer chemistry and to illustrate the capability of SEC-ESI-MS for the analysis of complicated polymers. The article addresses recent advancements in the uses of a variety of hyphenated techniques, such as the GC-MS method, LC-MS analysis, LC-FTIR, LC-NMR, CE-MS, and others.
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