PHOTOTHERAPY OUTCOMES AND BILIRUBIN ASSESSMENT TECHNIQUES IN PRETERM NEONATES: A TERTIARY CARE EXPERIENCE

Authors

  • AISHWARAYA MANTHALE Department of Paediatrics, Motherhood Hospital Whitefield Bangalore, India
  • TRIVENI DESAI Department of Paediatrics, Bidar Institute of Medical Science Bidar, India
  • RASHMI KAMATH Department of Paediatrics, Healthway Hospitals, Old Goa, India
  • VEERESH GODI Department of Paediatrics, Healthway Hospitals, Old Goa, India

DOI:

https://doi.org/10.22159/ijcpr.2025v17i1.6005

Keywords:

Neonatal jaundice,, Phototherapy, Preterm neonates, Transcutaneous bilirubin, Serum bilirubin, Tertiary care

Abstract

Objective: Management of neonatal jaundice, particularly in preterm neonates, is a significant challenge in neonatal care, with phototherapy serving as the primary treatment modality. This study evaluates the outcomes of phototherapy and the efficacy of different bilirubin assessment techniques in a tertiary care environment.

Methods: A hospital-based prospective observational study was conducted involving 100 preterm neonates. Transcutaneous (TcB) and total serum bilirubin (TSB) levels were measured before, during, and after phototherapy to assess correlations and differences.

Results: Statistically significant correlations were found between TcB and TSB post-phototherapy (r-value = 0.8154, p-value<0.0001) and during phototherapy (r-value = 0.6069, p-value<0.0001). However, TcB tended to underestimate bilirubin levels compared to TSB post-phototherapy, with a mean difference of -0.42 mg/dl (p-value = 0.0117).

Conclusion: Despite discrepancies with traditional serum bilirubin (TSB) measurements during and after phototherapy, TcB proves to be an effective tool in clinical practice. The findings suggest that with further refinement and adjustment for influencing factors, TcB can serve as an equivalent to serum assessments, reducing the need for invasive procedures in neonatal jaundice management.

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References

Maisels MJ, Mc Donagh AF. Phototherapy for neonatal jaundice. N Engl J Med. 2008;358(9):920-8. doi: 10.1056/NEJMct0708376, PMID 18305267.

Bhutani VK, Stark AR, Lazzeroni LC, Poland R, Gourley GR, Kazmierczak S. Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy. J Pediatr. 2013;162(3):477-482.e1. doi: 10.1016/j.jpeds.2012.08.022, PMID 23043681.

American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114(1):297-316. doi: 10.1542/peds.114.1.297, PMID 15231951.

Crosse VM. Management of neonatal jaundice. Paediatr Child Health. 2002;12(5):278-82.

Nakamura H, Yonetani M, Uetani Y, Funato M, Lee Y. Transcutaneous bilirubinometry: potential for overestimating bilirubin levels in term and near-term Japanese infants undergoing phototherapy. Acta Paediatr. 2008;97(2):164-9.

Keren R, Tremont K, Luan X, Cnaan A. Visual assessment of jaundice in term and late preterm infants. Arch Dis Child Fetal Neonatal Ed. 2009;94(5):F317-22. doi: 10.1136/adc.2008.150714, PMID 19307221.

Tan KL. The pattern of bilirubin response to phototherapy for neonatal hyperbilirubinaemia. Pediatr Res. 1982;16(8):670-4. doi: 10.1203/00006450-198208000-00018, PMID 7110789.

Stevenson DK, Vreman HJ, OH W, Fanaroff AA, Wright LL, Lemons JA. Bilirubin production in healthy term infants as measured by carbon monoxide in breath. Clin Chem. 1994;40(10):1934-9. doi: 10.1093/clinchem/40.10.1934, PMID 7923775.

Kaplan M, Bromiker R, Hammerman C. Severe neonatal hyperbilirubinemia and kernicterus: are these still problems in the third millennium? Neonatology. 2011;100(4):354-62. doi: 10.1159/000330055, PMID 21968213.

Eggert LD, Wiedmeier SE, Wilson J, Christensen RD. The effect of instituting a prehospital discharge newborn bilirubin screening program in an 18-hospital health system. Pediatrics. 2006;117(5):e855-62. doi: 10.1542/peds.2005-1338, PMID 16651290.

Bhutani VK, Johnson LH, Keren R. Diagnosis and management of hyperbilirubinemia in the term neonate: for a safer first week. Pediatr Clin North Am. 2004;51(4):843-61. doi: 10.1016/j.pcl.2004.03.011, PMID 15275978.

Gourley GR. Bilirubin metabolism and kernicterus. Adv Pediatr. 1997;44:173-229. doi: 10.1016/S0065-3101(24)00052-5, PMID 9265971.

Murki S, Kumar P, Majumdar S, Marwah D, Narang A, Bhutani VK. Risk factors for kernicterus in neonatal jaundice. Indian J Pediatr. 2016;83(5):387-92.

Shapiro SM. Bilirubin toxicity in the developing nervous system. Pediatr Neurol. 2003;29(5):410-21. doi: 10.1016/j.pediatrneurol.2003.09.011, PMID 14684236.

Published

15-01-2025

How to Cite

MANTHALE, A., T. DESAI, R. KAMATH, and V. GODI. “PHOTOTHERAPY OUTCOMES AND BILIRUBIN ASSESSMENT TECHNIQUES IN PRETERM NEONATES: A TERTIARY CARE EXPERIENCE”. International Journal of Current Pharmaceutical Research, vol. 17, no. 1, Jan. 2025, pp. 17-19, doi:10.22159/ijcpr.2025v17i1.6005.

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