A CLINICAL COMPARATIVE STUDY OF RENAL PARAMETERS OF OBESE AND HYPERTENSIVE PATIENTS WITH NON-OBESE HYPERTENSIVE PATIENTS
DOI:
https://doi.org/10.22159/ijcpr.2025v17i1.6057Keywords:
BMI, Renal parameters, Hypertension, Obese, Non-obeseAbstract
Objective: Obesity is associated with an early onset of glomerulomegaly, hemodynamic changes of a hyper-filtering kidney, and increased albuminuria. It is an important risk factor for incident CKD and increase risk of ESRD. The aim of the present study is to compare the influence of renal parameters among the obese and non-obese hypertensive patients attended to a tertiary care hospital.
Methods: The study was conducted on 120 patients who were divided into 4 groups Group ‘O’ comprises of obese individuals; Group ‘OH’, which comprises of 30 obese and hypertensive individuals; Group ‘NO, H’ which comprises of non-obese and hypertensive individuals and Group ‘C’ which comprises of 30 healthy control group having normal BMI.
Results: The mean±SD of serum creatinine was 0.88±0.06; 1.13±0.1; 0.7±0.08; 0.7±0.06 of all the 4 groups and the Serum urea mean±SD was 26.4±3.8; 36.6±5.42; 21.2±3.2; 20.4±3.2 and the Serum uric acid mean±SD levels were 4.3±0.64; 4.3±0.56; 3.8±0.3; 3.7±0.26 of all the 4 groups and eGFR values were 139.5±1.8; 95.3±23.20; 116.2±7.4;118.6±6.2 in obese, obese hypertensive, non-obese hypertensive and control subjects respectively. The results showed that there was a significant influence of renal parameters among the four tested groups.
Conclusion: The strategies to prevent weight gain and to induce weight loss in patients who are already obese would ultimately reduce the incidence of obesity-mediated renal disease.
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References
Zajac J, Shrestha A, Poretsky L. The main events in the history of diabetes mellitus. In: Poretsky L, editor. Principles of Diabetes Mellitus. Boston: Springer US; 2004. p. 19-37. doi: 10.1007/978-1-4757-6260-0_1.
Caleyachetty R, Meunnig P, Kengne AP. Misclassification of cardiometabolic health when using body mass index categories. Int J Obes (Lond). 2016 Aug;40(8):1332. doi: 10.1038/ijo.2016.65, PMID 27102047.
Gomez P, Ruilope LM, Barrios V, Navarro J, Prieto MA, Gonzalez O. Prevalence of renal insufficiency in individuals with hypertension and obesity/overweight: the FATH study. J Am Soc Nephrol. 2006 Dec;17(12) Suppl 3:S194-200. doi: 10.1681/ASN.2006080914, PMID 17130261.
Hall JE, Henegar JR, Dwyer TM, Liu J, DA Silva AA, Kuo JJ. Is obesity a major cause of chronic kidney disease? Adv Ren Replace Ther. 2004 Jan;11(1):41-54. doi: 10.1053/j.arrt.2003.10.007, PMID 14730537.
Tiffany TO, Jansen JM, Burtis CA, Overton JB, Scott CD. Enzymatic kinetic rate and endpoint analyses of substrate by use of a GeMSAEC fast analyzer. Clin Chem. 1972 Aug;18(8):829-40. doi: 10.1093/clinchem/18.8.829, PMID 5043271.
Tanganelli E, Prencipe L, Bassi D, Cambiaghi S, Murador E. Enzymic assay of creatinine in serum and urine with creatinine iminohydrolase and glutamate dehydrogenase. Clin Chem. 1982 Jul;28(7):1461-4. doi: 10.1093/clinchem/28.7.1461, PMID 7083556.
Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW. National kidney foundation practice guidelines for chronic kidney disease: evaluation classification and stratification. Ann Intern Med. 2003 Jul 15;139(2):137-47. doi: 10.7326/0003-4819-139-2-200307150-00013, PMID 12859163.
Kotsis V, Stabouli S, Papakatsika S, Rizos Z, Parati G. Mechanisms of obesity-induced hypertension. Hypertens Res. 2010 May;33(5):386-93. doi: 10.1038/hr.2010.9, PMID 20442753.
Kothari S, Shetty V, Bhori M. Clinical profile and comparison of renal insufficiency in obese and non-obese hypertensive patients: a cross-sectional comparative study. Panacea J Med Sci. 2023;13(3):704-11. doi: 10.18231/j.pjms.2023.129.
Osafo C, Mate Kole M, Affram K, Adu D. Prevalence of chronic kidney disease in hypertensive patients in Ghana. Ren Fail. 2011;33(4):388-92. doi: 10.3109/0886022X.2011.565140, PMID 21529267.
Sandhu JS, Singla M, Ahuja A. Renal risks of obesity. J Indian Acad Clin Med. 2004 Jan;5(4):335-8.
Kaufman JS, Durazo Arvizu RA, Rotimi CN, MC Gee DL, Cooper RS. Obesity and hypertension prevalence in populations of African origin. The investigators of the international collaborative study on hypertension in blacks. Epidemiology. 1996 Jul;7(4):398-405. doi: 10.1097/00001648-199607000-00010, PMID 8793366.
Hsu CY, MC Culloch CE, Iribarren C, Darbinian J, Go AS. Body mass index and risk for end-stage renal disease. Ann Intern Med. 2006 Jan 3;144(1):21-8. doi: 10.7326/0003-4819-144-1-200601030-00006, PMID 16389251.
Kambham N, Markowitz GS, Valeri AM, Lin J, D Agati VD. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int. 2001 Apr;59(4):1498-509. doi: 10.1046/j.1523-1755.2001.0590041498.x, PMID 11260414.
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