FORMULATION AND IN-VITRO EVALUATION OF MOUTH DISSOLVING TABLETS OF AMLODIPINE AND ROSUVASTATIN


Shireen Begum, Syed Abdul Azeez Basha, Shazia Fatima

Abstract


Objective: Mouth Dissolving Tablets (MDT) are most accepted and exploited for the drug delivery for the patients who are having difficulty with swallowing i.e., mainly pediatric's and Geriatric’s. Amlodipine besylate (ADB) is an anti-hypertensive and it is also used in many Coronary artery diseases, Whereas Rosuvastatin Calcium (RSC) is an anti-hyperlipidemia that prevents of Atheroma. In the present study a combination of ADB, RSC is formulated into a mouth dissolving tablet using three super disintegrants such as Croscarmellose Sodium (CCS), Cross povidone (CP), Sodium Starch Glycolate (SSG) at various concentrations to enhance the disintegration and dissolution of ADB, RSC to improve bioavailability of the drugs

Methods: The tablets were prepared by using direct compression method and evaluated for weight variations, Hardness, Friability, Wetting time, disintegration time (DT) and Dissolution study. Prepared tablets are subject to FT-IR Study for Characterization and compatibility study.

Results: No Chemical interaction between drug and excipients were indicated in the FT-IR. Disintegration and dissolution profiles decreases with addition of super disintegrating agents like Croscarmellose Sodium (CCS), Cross povidone (CP), Sodium Starch Glycolate (SSG).

Conclusion: Among all the formulation F12 with CP in 5% and SSG 5% Concentration found to be best in drug release profile.

Keywords: Mouth Dissolving Tablets, Amlodipine besylate, Rosuvastatin Calcium, super disintegrants, direct compression method.

| PDF | HTML |

References


P Ashish, MS Harsoliya, JK Pathan, S Shruti. A review-formulation of mouth dissolving tablet. Int J Pharm Clin Sci 2011;1:1-8.

Ajoy Bera, Ashish Mukherjee. A detailed study of mouth dissolving drug delivery system. Acta Chim Pharm Indica 2013;3:65-93.

Arijit Gandhi. Mouth dissolving tablets: a new venture in modern formulation technology. Pharma Innovation 2012;1:14-31.

Sharma Deepak, Kumar Dinesh, Singh Mankaran, Singh Gurmeet, Rathore. Fast disintegrating tablets: a new era in novel drug delivery system and new market opportunities. J Drug Delivery Ther 2012;2:74-86.

Saxene vaubhav, Khinchi Mahaveer, Gupta MK, Agarwal Dilip, Sharma Natasha. “Orally disintegration tablet: friendly dosage form” Int J Res Ayurveda Pharm 2010;1:399-407.

Mukesh P Ratnaparkhi, GP Mohanta, Lokesh Upadhyay. “Review on: rapid dissolving tablet”. J Pharm Res 2009;2:63-9.

Dali Shukla, Subhashis Chakraborty, Sanjay Singh, Brahmeshwar Mishra. Mouth dissolving tablets i: an overview of evaluation techniques. Sci Pharm 2009;77:327–41.

Harlalka SS, Chaware VJ, Deshmane SV, Biyani KR. Formulation and evaluation of orodispersible tablet containing amlodipine besylate. Int J Curr Pharm Res 2014;6:38-41.

Ehsan Ali Mohamed. Shaimaa N, Abd Al Hammid. Formulation and evaluation of rosuvastatin orodispersible tablets. Int J Pharm Pharm Sci 2013;5 Suppl 2:339-46.

Ganji Amarnath Reddy, Balaji, Naveen Kj, Rajesh Bsb, Yedla Anil Chowdary. Formulation and evaluation of oral fast disintegrating tablets by using amlodipine besylate solid dispersion by direct compression method. Scholars Res Library 2012;4:683-94.

Nehal Siddiqui, Garima Garg, Pramod Kumar Sharma. Fast dissolving tablets: preparation, characterization and evaluation: an overview. Int J Pharm Sci Rev Res 2010;4:87.

Deshmukh Keshav Ram, Patel Vidyanand. A review on mouth dissolving tabletstechniques. Int J Res Ayurveda Pharm 2013;3;23-32.




About this article

Title

FORMULATION AND IN-VITRO EVALUATION OF MOUTH DISSOLVING TABLETS OF AMLODIPINE AND ROSUVASTATIN

Date

15-07-2015

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 7, Issue 3, 2015 Page: 81-91

Online ISSN

0975-7066

Statistics

334 Views | 124 Downloads

Authors & Affiliations

Shireen Begum
Department of Pharmaceutics, Deccan School of Pharmacy, Darussalam, Hyderabad

Syed Abdul Azeez Basha
Department of Pharmaceutics, Deccan School of Pharmacy, Darussalam, Hyderabad

Shazia Fatima
Department of Pharmaceutics, Deccan School of Pharmacy, Darussalam, Hyderabad


Refbacks

  • There are currently no refbacks.