SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NOVEL 2-ARYL SUBSTITUTED BENZOTHIAZOLE DERIVATIVES

  • Rupali Likhar Gahlot Institute of Pharmacy, Plot No-59, Sector-14, Koperkhairane, Navi Mumbai 400709 (M. S.), India
  • P. Perumal
  • Nitin Kolhe
  • V. H. Bhaskar
  • Pratibha Daroi

Abstract

Objective: A series of 2-aryl substituted benzothiazole was designed and synthesized with various substituted benzoic acid. 2-mercaptobenzothiazole and thionyl chloride also used to get carbothiaote. The present study was carried to assess the pharmacological potential towards antioxidant activity of 2-aryl substituted benzothiazole derivatives.

Methods: The antioxidant activity of the synthesized compounds was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH), and superoxide radical scavenging assay methods.

Results: Compounds showed significant radical scavenging potential due to the presence of electron donating substituent.

Conclusion: These indicate that benzothiazole derivatives showed the defence mechanism to prevent formation of excess free radicals.

Keywords: Synthesis, Anti-oxidant activity and 2-aryl substituted benzothiazole derivatives.

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How to Cite
Likhar, R., P. Perumal, N. Kolhe, V. H. Bhaskar, and P. Daroi. “SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NOVEL 2-ARYL SUBSTITUTED BENZOTHIAZOLE DERIVATIVES”. International Journal of Current Pharmaceutical Research, Vol. 7, no. 4, 1, pp. 34-37, https://innovareacademics.in/journals/index.php/ijcpr/article/view/9081.
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