SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NOVEL 2-ARYL SUBSTITUTED BENZOTHIAZOLE DERIVATIVES


Rupali Likhar, P. Perumal, Nitin Kolhe, V. H. Bhaskar, Pratibha Daroi

Abstract


Objective: A series of 2-aryl substituted benzothiazole was designed and synthesized with various substituted benzoic acid. 2-mercaptobenzothiazole and thionyl chloride also used to get carbothiaote. The present study was carried to assess the pharmacological potential towards antioxidant activity of 2-aryl substituted benzothiazole derivatives.

Methods: The antioxidant activity of the synthesized compounds was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH), and superoxide radical scavenging assay methods.

Results: Compounds showed significant radical scavenging potential due to the presence of electron donating substituent.

Conclusion: These indicate that benzothiazole derivatives showed the defence mechanism to prevent formation of excess free radicals.

Keywords: Synthesis, Anti-oxidant activity and 2-aryl substituted benzothiazole derivatives.

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References


Siddiqui N, Rana A. Benzothiazole, a new profile of biological activities. Indian J Pharm Sci 2007;69:10-7.

Shah VH, Trivedi BH. Synthesis of some benzothiazole derivative. Indian Drugs 2000;29:262-4.

Shi DF, Bradshaw TD. Antitumor benzothiazoles: synthesis of 2-(4-aminophenyl) benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. J Med Chem 1996;39:3375-84.

Recane L. Antimicrobial and anti HIV agent of benzothiazole derivatives. Indian J Heterocycl Chem 2001;55:2085.

Malcolm FG. Steven, The synthesis and antitumour activity of benzothiazole substituted quinol derivatives. Bioorg Med Chem Lett 2000;10:513-5.

Nadeem Siddiqui. Synthesis of some new benzothiazole incorporated sulphonamido as potential anticonvulsant. Indian J Heterocycl Chem 2004;13:361-4.

Pattan SR, Narendra babu SN. Synthesis and antifungal activity of 2-amino [5’-(4-sulphonylbenzylidene)-2, 4-thiazolidene Dione]-7-(substituted)-6-fluro benzothiazoles. Indian J Heterocycl Chem 2002:11:333-4.

Bhusari KP. Synthesis and antimicrobial activity of some 2-substituted Aminobenzothiazole. Indian J Heterocycl Chem 2001;10:231-2.

Vibhute VB. Synthesis and antibacterial activityof some new 2-(substituted phenyl) sulphonamido)-6-substituted benzothiazoles. Indian J Heterocycl Chem 2001;11:79-80.

FA Hassan. “Synthesis, characterization, anti-inflammatory, and antioxidant activities of some new thiazole derivatives”. Int J Appl Sci Biotechnol 2012;7:180–7.

O I Aruoma. “Free radicals, oxidative stress, and antioxidants in human health and disease”. J Am Oil Chem Soc 1998;75:199–12.

BN Ames, MK Shigenaga, TM Hagen. “Oxidants, antioxidants, and the degenerative diseases of aging.” Proc Natl Acad Sci USA 1993;90:7915–22.

YK Tyagi, A Kumar, HG Raj. “Synthesis of novel amino and acetyl amino-4-methylcoumarins and evaluation of their antioxidant activity”. Eur J Med Chem 2005;40:413–20.

S. Santosh Kumar, KI Priyadarsini, KB Sainis. “Free radical scavenging activity of vanillin and o-vanillin using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical”. Redox Rep 2002;7:35–40.

D Kovala-Demertzi, A Galani, MA Demertzis, S Skoulika, C Kotoglou. “Binuclear copper (II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity”. J Inorg Biochem 2004;98:358–64.




About this article

Title

SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NOVEL 2-ARYL SUBSTITUTED BENZOTHIAZOLE DERIVATIVES

Date

17-10-2015

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 7, Issue 4, 2015 Page: 34-37

Online ISSN

0975-7066

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230 Views | 74 Downloads

Authors & Affiliations

Rupali Likhar
Gahlot Institute of Pharmacy, Plot No-59, Sector-14, Koperkhairane, Navi Mumbai 400709 (M. S.), India
India

P. Perumal

Nitin Kolhe

V. H. Bhaskar

Pratibha Daroi


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