ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC ACTIVITY OF SONERILA TINNEVELLIENSIS FISCHER WHOLE PLANT IN ALLOXAN INDUCED DIABETIC RATS


Komalavalli T., Packia Lincy M., Muthukumarasamy S., Mohan V. R.

Abstract


Objective: The ethanol extract of Sonerila tinnevelliensis Fischer whole plant was investigated for its antidiabetic and antihyperlipidaemic effect in Wistar Albino rats.

Methods: Diabetes was induced in Albino rats by administration of alloxan monohydrate (150 mg/kg, i. p). The ethanol extracts of S. tinnevelliensis at a dose of 200 and 400 mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 14 d. The effect of ethanol extract of S. tinnevelliensis whole plant extract on blood glucose, plasma insulin, creatinine, urea, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglycerides (TG), low density lipoprotein–cholesterol (LDL-C), very low density lipoprotein–cholesterol (VLDL-C), high density lipoprotein–cholesterol (HDL-C) and phospholipid (PL)] serum protein, albumin, globulin, serum enzymes [serum glutamate pyruvate transaminases (SGPT), serum glutamate oxaloacetate transaminases (SGOT), and alkaline phosphatase (ALP)] were measured in the diabetic rats.

Results: The ethanol extract of S. tinnevelliensis whole plant elicited significant reductions of blood glucose (p<0.05), lipid parameters except HDL-C, serum enzymes and significantly increased HDL-C. The extracts also caused significant increase in plasma insulin (p<0.05) in the diabetic rats.

Conclusion: The ethanol extracts of S. tinnevelliensis whole plant possesses significant antidiabetic and antihyperlipidaemic effects in alloxan induced diabetic rats.

Keywords: Sonerila tinnevelliensis, Diabetes mellitus, Alloxan, Hyperglycemia.

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About this article

Title

ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC ACTIVITY OF SONERILA TINNEVELLIENSIS FISCHER WHOLE PLANT IN ALLOXAN INDUCED DIABETIC RATS

Date

17-10-2015

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Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 7, Issue 4, 2015 Page: 53-57

Online ISSN

0975-7066

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Authors & Affiliations

Komalavalli T.

Packia Lincy M.

Muthukumarasamy S.

Mohan V. R.
3Department of Botany, Sri K. G. S. Arts College, Srivaikuntam, Tamil Nadu, India


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