APPLICATION OF IPOM OEA BATATA STARCH MUCILAGE AS SUSPENDING AGENT IN OSELTAMIVIR SUSPENSION
Keywords:Oseltamivir, Suspension, Sedimentation volume, redispersibility, flocculation
Objective: The objective of the study was to search for a cheap and effective natural raw material that can serve as an alternative suspending agent in the formulation of oseltamivir suspension. The phytochemical and the physicochemical properties of the mucilage of Ipomoea batata starch were studied.
Methods: The suspending properties of mucilage extract of I. batata starch was evaluated comparatively with that of acacia, xanthum gum and sodium alginate using model formulations at concentrations of 0.75, 1.5and 3.5% w/v. The Prepared suspensions were evaluated by studying different parameters like pH, sedimentation volume, redispersibility, Flow rate (F), viscosity, degree of flocculation, effect, effect of temperature and stability studies.
Results: The results showed the presence of flavonoids, saponin, protein, carbohydrate and reducing sugars. The rheological properties of suspension showed that As the concentration of suspending agent increased viscosity also get increased which reduces the sedimentation and contributes to the stability of suspension. Increase in viscosity avoids the particle aggregation so particles remain in a flocculated state. While an increase in temperature did not significantly increased the viscosity of suspension. The order of stability of suspension in terms of sedimentation profile ranked thus: OF3 (3%w/v IBSM)>OF12 (3%w/v SA)>OF6 (3%w/v AG)>OF9 (3%w/v XG)>B (5%w/v potato starch).
Conclusion: These results indicate that mucilage from I. batata starch in oseltamivir suspension has low sedimentation rate, medium viscosity and easily dispersible and can therefore serve as suspending agent in formulations of suspensions of sparingly soluble drugs.
KPS Kumar, D Bhowmik, S Srivastava, S Paswan, AS Dutta. Sustained release drug delivery system potential. Pharma Innovation 2012;1:46-56.
HC Ansel, LV Allen, NG Popovich. Pharmaceutical dosage forms and drug delivery system: seventeenth ed; 1999.
LA Sabri, AA Abdul-Rasool, MA Shehab. Formulation of rifampicin suspension. Iraqi J Pharm Sci 2006;15:1-7.
Ogaji SW Hoag. Effect of grewia gum as a suspending agent on ibuprofen Pediatric formulation. AAPS Pharm Sci Tech 2011;12:507-13.
R Kumar, MB Patil, SR Patil, MS Paschapur. Evaluation of Abelmoschus Esculentus mucilage as suspending agent in paracetamol suspension. Int J Pharm Res 2009;1:658-65.
G Zografi, H Schott, J Swarbrick. Disperse systems. In: Remingtonâ€™s Pharmaceutical Sciences, eighteenth. ed. Mack Publishing Co, Easton; 1990.
TR Bhardwaj, M Kanwar, R Lal, A Gupta. Natural gums and modified natural gums as sustained-release carriers. Drug Dev Ind Pharm 2000;26:1025-38.
Ogaji. Some physicochemical properties of acetaminophen pediatric suspensions formulated with okra gums obtained from different extraction processes as suspending agent. Asian J Pharm 2011;5:15-20.
S Mann, NK Jain, MD Kharya. Evaluation of the suspending properties of Cassia tora mucilage on sulphadimidine suspension. Asian J Exp Sci 2007;21:63-7.
V Senthil, D Sripreethi. Formulation and evaluation of paracetamol suspension from Trigonella Foenum Graecum mucilage. J Adv Pharm Edu Res 2011;1:225-33.
Trigonella foenum-graecum information from NPGS/GRIN. Available from: URL: http://Www.ars-grin.gov. [Last accessed on 13 Mar 2008].
V Sabale, V Patel, A Paranjape, P Sabale. Isolation of fenugreek seed mucilage and itâ€™s comparative evaluation as a binding agent with standard index. Int J Pharm Res 2009;1:56-62.
How to Series: Growing Methi (Fenugreek). A blog called "Fenugreek Love"; 2011.
P Ball. Quinolone generations: natural history or natural selection? J Antimicrob Chemother 2000;46 Suppl 1:17-24.
CM Oliphant, GM Green. Quinolones: a comprehensive review. Am Fam Physician 2002;65:455â€“64.
KA Rodvold, SC Piscitelli. New oral macrolide and fluoroquinolone antibiotics: an overview of pharmacokinetics, interactions, and safety. Clin Infect Dis 1993;17 Suppl 1:192â€“9.
S Bharath, NJ Patel, R Deweswaran, BV Bsavaraj, V Madhavan. Formulation and evaluation of Norfloxacin suspension using Fenugreek husk as natural suspending agent. Int J Pharm Res Dev 2012;4:16-21.
K Nayak, D Pal, J Pradhan, T Ghorai. The potential of Trigonella foenum-graecum L. Seed mucilage as suspending agent. Indian J Pharm Edu Res 2012;46:312-7.
JC Richardson, PW Dettmar, FC Hampson. Oesophageal bioadhesion of sodium alginate suspension: particle swelling and mucosal retention. Eur J Pharm Sci 2004;23:49-56.
KR Khandelwal. Practical Pharmacognosy, Techniques and Experiments. 9th edition. Nirali prakashan; 2002. p. 149-56.
HA Libermann, L Lachmann, BS Joseph, JL Kanig. Compression and consolidation of powdered solids. In: The Theory and Practice of Industrial Pharmacy; third ed. Varghese Publishing House, Mumbai; 1987. p. 67â€“71.
HA Lieberman, L Lachman, BS Joseph, JL Kanig. Preformulation. In: The Theory and Practice of Industrial Pharmacy. 3rd ed. Varghese Publishing House, Mumbai; 1987. p. 183â€“4.
D Pal, AK Nayak, S Kalia. Studies on Basella alba L. Leaves mucilage: Evaluation of suspending properties. Int J Drug Dis Tech 2010;1:15-20.
JD Strum, JL Colaizzi, TJ Goehl, JM Jaffe, WH Pitlick, VP Shah, et al. Bioavailability of sulfonamide suspensions I: dissolution profiles of sufamethizole using paddle method. J Pham Sci 1978;67:1399-402.
G Venkateshwarlu, D Rambu, BR Ramesh, VVS Rao. Dissolution kinetics of rifampicin aqueous suspension. Indian Drugs 1990;28:8-12.
Sameer J Nadaf, Sachin S Mali, Sachin S Salunkhe, Piyush M Kamble. Formulation and evaluation of ciprofloxacin suspension using natural suspending agent. Int J Pharm Sci Res 2014;5:63-70.
V Senthil, D Sripreethi. Formulation and evaluation of paracetamol suspension from Trigonella Foenum Graecum mucilage. J Adv Pharm Educ Res 2011;5;225-33.
Onyishi Ikechukwu V, Chime Salome A, Kanu Ifeoma. Application of Ipomoea batatas starch as suspending agent in acetaminophen suspension. Afr J Pharm Pharmacol 2014;8:24-30.