TRANSITION METAL COMPLEXATION WITH NAPROXEN AND EVALUATION OF THEIR IN VITRO ANTIMICROBIAL, CYTOTOXIC AND ANTHELMINTIC PROPERTIES


Sharif Hasan, Farida Begum

Abstract


Objective: The specific objective of this research was to synthesize transition metal complexes and investigate in vitro antimicrobial, cytotoxic and anthelmintic effects of naproxen and its complexes.

Methods: Naproxen was complexed with copper, cobalt iron, silver and zinc and the characterization of these compounds were performed by proton NMR, FTIR, DSC, SEM, HPLC and elemental analysis. The antimicrobial activity was evaluated by disc diffusion method and cytotoxicity was evaluated by using brine shrimp lethality bioassay and compared with vincristine sulfate. The anthelmintic activity was evaluated against Pheritima posthuma.

Results: Naproxen silver and zinc complexes showed potent activity while copper and cobalt complexes showed variable antimicrobial activity against some tested microorganisms. Naproxen iron complex showed moderate antimicrobial and very potent cytotoxic activity. According to these results we thought there might be any possibility to have anthelmintic properties on those complexes. However, we did not find any anthelmintic activity from them.

Conclusion: The present study demonstrated that few naproxen metal complexes possess comprehensive antimicrobial and cytotoxic activities.

Keywords: Naproxen, Antimicrobial, Cytotoxic, Anthelmintic.


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References


Kostova IP, Manolov II, Nicolova IN, Danchev ND. New metal complexes of 4-methyl-7-hydroxycoumarin sodium salt and their pharmacological activity. II Farmaco 2001;56:707-13.

Sheikhshoaie I, Badiei A, Ghazizadeh M. Synthesis and spectroscopic studies of two new complexes containing Fe (III) and Mo (VI) of two tridentate ONO donor sets ligands. Der Chem Sin 2012;3:24.

Borhade S. Synthesis, characterisation and spectrophotometric determination of Fe(II) complex of 2,4-dihydroxybenzaldehyde isonicotinoyl hydrazone {(E)-N’-(2,4-dihydroxybenzylidene) isonicotinohydrazide, it’s application and biological activity. Der Chem Sin 2011;2:64-71.

Habib SI, Baseer MA, Kulkarni PA. Synthesis and antimicrobial activity of Cobalt (II), Nickel (II), and Copper (II) complexes of some 2'-hydroxychalcones. Der Chem Sin 2011;2:27-32.

Munde AS, Shelke VA, Jadhav SM, Kirdant AS, Vaidya SR, Shankarwar SG, et al. Synthesis, Characterization and antimicrobial activities of some transition metal complexes of biologically active asymmetrical tetradentate ligands. Adv Appl Sci Res 2012;3:175-82.

Sabastiyan A, Suvaikin MY. Synthesis, characterization and antimicrobial activity of 2-(dimethylaminomethyl)isoindoline-1,3-dione and its cobalt(II) and nickel(II) complexes. Adv Appl Sci Res 2012;3:45-50.

Kostova I, Momekov G. New zirconium (IV) complexes of coumarins with cytotoxic activity. Eur J Med Chem 2006;41:717-26.

Adekunle FA, Woods JAO, Onawumi OOE, Odunola OA. Synthesis and characterization of nickel(II) complexes of various substituted acid hydrazides. Asian J Chem 2010;22:5543-50.

Bauer AW, WM Kirby, JC Sherries, M Turck. Antibiotic susceptibility testing by standardised single disc method. Am J Clin Pathol 1966;44:493-6.

Hossain MS, Hossain MA, Islam R, Alam AHMK, Zahan K, Sarkar S, et al. Antimicrobial and cytotoxic activities of 2-aminobenzoic acid and 2-aminophenol and their coordination complexes with Magnesium (Mg-II). Pak J Biol Sci 2004;7:25-7.

Islam MA, Sayeed MA, Islam MA, Khan GR, Mosaddik MA, Bhuyan MS, et al. Terpenes from bark of Zanthoxylum budrunga and their cytotoxic activities. Rev Latinoamer Quim 2002;30:24-8.

Aziz A, Raju GS, Das A, Ahmed J, Moghal MMR. Evaluation of in vitro anthelmintic activity, total phenolic content and cytotoxic activity of crinum latifolium L. (Family: Amaryllidaceae). Adv Pharm Bull 2014;4:15-9.

Malvankar PR. Anthelmintic activity of water extracts of Trikatu churna and its individual ingredients on Indian earthworms. Int J Pharm Biol Sci 2012;3:374-8.

Kuri S, Billah MM, Rana SMM, Naim Z, Islam MM, Hasanuzzaman M, Ali MR, et al. Phytochemical and in vitro biological investigations of methanolic extracts of Enhydra fluctuans Lour. Asian Pac J Trop Biomed 2014;4:299-305.

Lebl T, Holecek J, Lycka A. Synthesis characterization and biological activity of triorganotin 2-Phenyl-1,2,3-Triazole-4-Carboxylates. Sci Pap Univ Pardubice Ser A 1996;A2:5.

Battaglia LP, Corradi AB, Marcotrigiano G, Menabue L, Pellacani GC. Synthesis and spectroscopic and structural properties of bis(N-acetyl-DL-tryptophanato)copper(II) complex and its amine adducts. Effect of amines on the amino acid coordination. Crystal and molecular structure of diaquabis(N-acetyl-DL-tryptophanato)bis(pyridine)copper(II). J Am Chem Soc 1980;102:2663-9.

Battaglia LP, Corradi AB, Marcotrigiano G, Menabue L, Pellacani GC. Copper(II) complexes of nitrogen-protected amino acids: synthesis and spectroscopic, magnetic, and structural properties of bis(N-acetyl-. beta.-alaninato)diaquacopper(II) and tetrakis[. mu.-(N-acetyl-. beta.-alaninato)]-diaquadicopper(II) dihydrate. A case of structural isomerism. Inorg Chem 1981;20:1075-80.

Antolini L, Menabue L, Pellacani GC, Saladini M, Battaglia LP, Corradi AB, et al. Notes. Magnetic and spectroscopic properties of dimeric copper (ΙΙ) complexes of N-benzyloxycarbonyl-substituted amino acid anions. J Chem Soc Dalton Trans 1984;10:2325-6.

Miernik D, Golonka MDC, Szulc ZA. Communication the first examples of the coordination ability of 9-OXO-10-Acridineacetic Ion, an important interferon inducer. J Coord Chem 1989;20:203-7.

Behrens NB, Diaz GM. Metal complexes of the antibiotic nalidixic acid. Inorg Chim Acta 1986;125:21-6.

Azocar. Synthesis and characterization of silver(I) complexes withligands having anti-inflammatory properties. J Commun Inorg Synth 2013;1:19-21.

Workentine ML, Harrison JJ, Stenroos PU, Ceri H, Turner RJ. Pseudomonas fluorescens’ view of the periodic table. Environ Microbiol 2008;10:238–50.

Nies DH. Efflux-mediated heavy metal resistance in prokaryotes. FEMS Microbiol Rev 2003;27:313–39.

Harrison JJ, Ceri H, Turner RJ. Multimetal resistance and tolerance in microbial biofilms. Nat Rev Microbiol 2007;5:928–38.

Harrison GA, Dawson KA, Hemkenm RW. Effects of high iron and sulfate ion concentrations on dry matter digestion and volatile fatty acid production by ruminal microorganisms. J Anim Sci 1992;70 :1188-94.

Chamnogpol S, Dodson W, Cromie MJ, Harris ZL, Groisman EA. Fe (III) mediated cellular toxicity. Mol Microbiol 2002;45:711-9.




About this article

Title

TRANSITION METAL COMPLEXATION WITH NAPROXEN AND EVALUATION OF THEIR IN VITRO ANTIMICROBIAL, CYTOTOXIC AND ANTHELMINTIC PROPERTIES

Date

17-10-2015

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 7, Issue 4, 2015 Page: 63-69

Online ISSN

0975-7066

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119 Views | 12 Downloads

Authors & Affiliations

Sharif Hasan
Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh

Farida Begum


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