EFFECT OF Solanum villosum (Mill.) EXTRACT AND ITS SILVER NANOPARTICLES ON HEMOPOIETIC SYSTEM OF DEN INDUCED HCC IN RATS

  • Rajendran Venkatesh Department of Biochemistry, kongunadu arts and science college, coimbatore, Tamilnadu, India

Abstract

ABSTRACT

Objective: This study aims to elucidate the different forms of Solanum villosum, ethanolic leaf extract of Solanum villosum (EESV) and Solanum villosum silver nanoparticles (SV-AgNPs) on hematological parameters in diethylnitrosamine (DEN) induced hepatocellular carcinoma in rats. Materials and Methods: Thirty male albino wistar rats were randomly assigned into five groups of six rats each. Group 1 was control, while groups 2 (DEN control), group 3 (EESV 200 mg / kg b.w), group 4 (SV-AgNPs 100 µg / kg b.w i.p), group 5 (Cyclophosphamide 50 mg / kg. b.w), orally for 16 weeks, respectively. Rats in all six groups received normal pallet diet and drinking water ad libitum. Complete blood count was done using SYSMEX Xs – 800 i automatic hematology analyzer.

Results and Discussion: Rats treated with DEN showed severe toxic symptoms and significant decrease in (P < 0.05) Hb, PCV, RBC, MCV, MCH, MCHC and platelets levels except white blood cell counts (WBC). After, the administration of ethanolic extract of Solanum villosum (EESV) and Solanum villosum silver nanoparticles (SV-AgNPs) showed a protective effect on hemopoietic levels of DEN induced rats.

Conclusion: Thus it is concluded that oral administration of ethanolic extract of Solanum villosum (EESV) and Solanum villosum silver nanoparticles (SV-AgNPs) caused an increased in the level of Hb concentration, PCV, RBC, MCV, MCH, MCHC and platelets. Whereas level of white blood cells was reduced in DEN induced hepatocellular carcinoma. 

 

Keywords:  Ethanolic extract of Solanum villosum (EESV), Solanum villosum silver nanoparticles (SV-AgNPs), diethylnitrosamine (DEN), white blood cells.

 

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How to Cite
Venkatesh, R. (2017). EFFECT OF Solanum villosum (Mill.) EXTRACT AND ITS SILVER NANOPARTICLES ON HEMOPOIETIC SYSTEM OF DEN INDUCED HCC IN RATS. Innovare Journal of Health Sciences, 5(1), 13-16. Retrieved from https://innovareacademics.in/journals/index.php/ijhs/article/view/15459
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