• MOHIUDDIN AK Department of Pharmacy, World University of Bangladesh, Dhaka, Bangladesh.


UVC, UVB, and UVA, The ozone layer ingests 100 of UVC


The sunscreen industry is achieving remarkable worldwide prominence by responding to the growing need for skin protection with fast-paced innovation. Increased consumer awareness of the harmful effects of sunlight has fueled the demand for improved photoprotection. The need for broad-spectrum protection from both ultraviolet (UV) A and UV B rays has inspired scientists worldwide to research new cosmetic formulations and delivery systems. More effective sunscreen actives, emollients and novel cosmetic and functional ingredients have been regularly added to the formulator’s repertoire. Creativity in innovation has been hindered only by regulatory agencies and patent restrictions worldwide. Familiarity with the current restrictive regulations and patent law infringements has become integral to any research effort attempting to provide improved protection to individuals affected by the sun’s damaging effects. The increasing incidence of skin cancers and photodamaging effects caused by UV radiation has increased the use of sun screening agents which have shown beneficial effects in reducing the symptoms and reoccurrence of these problems. Unlike the situation in Europe where sunscreen ingredients are considered under cosmetics guidelines, the food and drug administration (FDA) is required to define sunscreens as drugs since they are advertised to prevent sunburn and, more recently, the risk of skin cancer. In the USA, the FDA has been regulating this industry since August 25, 1978, with the publication of the advance notice of proposed rulemaking. Sunscreens are considered drugs and cosmetics and therefore must be governed by the FDA-over-the-counter monograph. With the variety of sunscreen agents used in cosmetic and UV protection products, Australia, Canada, and the European Union (EU) have also developed regulatory protocols on safe sunscreen product use. Unlike the USA, though, Australia has approved 34 active sunscreen ingredients and the EU has approved 28 of these ingredients. Current FDA regulations allow labeling of sunscreen products to a maximum of 30þ, despite the many products currently available with numbers as high as 100. From a cosmetic formulation point of view, increasing the sun protection factor number in a product is governed by simple chemical principles.

Author Biography

MOHIUDDIN AK, Department of Pharmacy, World University of Bangladesh, Dhaka, Bangladesh.

Assistant Professor, Faculty of Pharmacy


Dale Wilson B, Moon S, Armstrong F. Comprehensive review of ultraviolet radiation and the current status on sunscreens. J Clin Aesthet Dermatol 2012;5:18-23.

Sivamani RK, Crane LA, Dellavalle RP. The benefits and risks of ultraviolet tanning and its alternatives: The role of prudent sun exposure. Dermatol Clin 2009;27:149-54, 6.

Pinto I, Bogi A, Picciolo F, Stacchini N, Buonocore G, Bellieni CV. Blue light and ultraviolet radiation exposure from infant phototherapy equipment. J Occup Environ Hyg 2015;12:603-10.

de Groot T, Chowdhary A, Meis JF, Voss A. Killing of Candida auris by UV-C: Importance of exposure time and distance. Mycoses 2019;62:408-12.

Dai T, Kharkwal GB, Zhao J, St Denis TG, Wu Q, Xia Y, et al. Ultraviolet-C light for treatment of Candida albicans burn infection in mice. Photochem Photobiol 2011;87:342-9.

Nussbaumer B, Kaminski-Hartenthaler A, Forneris CA, Morgan LC, Sonis JH, Gaynes BN, et al. Light therapy for preventing seasonal affective disorder. Cochrane Database Syst Rev 2015;3:CD011269.

Lam RW, Levitt AJ, Levitan RD, Michalak EE, Cheung AH, Morehouse R, et al. Efficacy of bright light treatment, fluoxetine, and the combination in patients with nonseasonal major depressive disorder: A randomized clinical trial. JAMA Psychiatry 2016;73:56-63.

Budzowski A. Sunburn vs Sun Poisoning, Web UPMC MyHealth Matters.

Moan J, Grigalavicius M, Dahlback A, Baturaite Z, Juzeniene A. Ultraviolet-radiation and health: Optimal time for sun exposure. Adv Exp Med Biol 2014;810:423-8.

Guerra KC, Crane JS. Skin Cancer Prevention. Treasure Island, FL: StatPearls Publishing; 2019.

MedicineNet. Sunburn (Sun Poisoning) Symptoms, Pain Relief, and Healing Time, Medically. Available from:. [Last accessed on 2018 Oct 04].

MedicineNet. Get Rid of Sunburn Fast: Pain Relief, Blisters, Peeling, Home Remedies; 2012.

Koh D, Wang H, Lee J, Chia KS, Lee HP, Goh CL. Basal cell carcinoma, squamous cell carcinoma and melanoma of the skin: Analysis of the Singapore cancer registry data 1968-97. Br J Dermatol 2003;148:1161-6.

Amaro-Ortiz A, Yan B, D’Orazio JA. Ultraviolet radiation, aging and the skin: Prevention of damage by topical cAMP manipulation. Molecules 2014;19:6202-19.

Amblard P, Leccia MT. Skin diseases with photosensitivity. Rev Prat 1992;42:1365-8.

Zuba EB, Koronowska S, Osmola-Mańkowska A, Jenerowicz D. Drug-induced Photosensitivity. Acta Dermatovenerol Croat 2016;24:55-64.

WebMD. Sun Poisoning. Available from: skin-problems-and-treatments/sun-poisoning#1.

Golmohammadzadeh S, Imani F, Hosseinzadeh H, Jaafari MR. Preparation, characterization and evaluation of sun protective and moisturizing effects of nanoliposomes containing safranal. Iran J Basic Med Sci 2011;14:521-33.

Opene C, Chren MM, Linos E. Types of shade vary in protection just like sunscreens. JAMA Dermatol 2017;153:1070-1.

Wolf R, Matz H, Orion E, Lipozencić J. Sunscreens the ultimate cosmetic. Acta Dermatovenerol Croat 2003;11:158-62.

Rego D, Fernandes L, Nascimento T, Grenha A. Evaluation of a sunscreen during a typical beach period. J Pharm Bioallied Sci 2010;2:47-50.

Ruszkiewicz JA, Pinkas A, Ferrer B, Peres TV, Tsatsakis A, Aschner M. Neurotoxic effect of active ingredients in sunscreen products, a contemporary review. Toxicol Rep 2017;4:245-59.

Kannan S, Lim HW. Photoprotection and Vitamin D: A review. Photodermatol Photoimmunol Photomed 2014;30:137-45.

Pandika M. Looking to nature for new sunscreens. ACS Cent Sci 2018;4:788-90.

Food and Drug Administration. Sunscreen: How to Help Protect Your Skin from the Sun. Silver Spring, Maryland: Food and Drug Administration; 2019.

Only two of the 16 Ingredients in Sunscreen are Definitely Safe, FDA Declares: Two Other Chemicals will be banned as the Agency Demands More Research on the other. Available from: https://www.dailymail.

Gabros S, Zito PM. Sunscreens and Photoprotection. Treasure Island, FL: StatPearls Publishing; 2019.

Food and Drug Administration. Aims to Strengthen Sunscreen Rules. Silver Spring, Maryland: Medical Press (Health), Food and Drug Administration; 2019.

Maddipatla M. U.S. FDA Proposes New Regulations for Over-the-counter Sunscreens. Reuters. Silver Spring, Maryland: Food and Drug Administration; 2019.

Ripamonti E, Allifranchini E, Todeschi S, Bocchietto E. Endocrine Disruption by Mixtures in Topical Consumer Products. Cosmetics 2018;5:61.

Raffa RB, Pergolizzi JV Jr., Taylor R Jr., Kitzen JM, NEMA Research Group. Sunscreen bans: Coral reefs and skin cancer. J Clin Pharm Ther 2019;44:134-9.

Guerra KC, Crane JS. Sunburn. Treasure Island, FL: StatPearls Publishing; 2019.

McStay CM. What is the Pathophysiology of Sunburn? Medscape; 2018.

Kellerman RD, Rakel D, editors. Diseases of the skin. In: Conn’s Current Therapy. Ch. 14. New York: Elsevier Health Sciences; 2019. p. 1031.

Latha MS, Martis J, Shobha V, Sham Shinde R, Bangera S, Krishnankutty B, et al. Sunscreening agents: A review. J Clin Aesthet Dermatol 2013;6:16-26.

Azevedo M, Bandeira L, Luza C, Lemos A, Bandeira F. Vitamin D deficiency, skin phototype, sun index, and metabolic risk among patients with high rates of sun exposure living in the tropics. J Clin Aesthet Dermatol 2018;11:15-8.

Kaur A, Thatai P, Sapra B. Need of UV protection and evaluation of efficacy of sunscreens. J Cosmet Sci 2014;65:315-45.

Schwarz T. Mechanisms of UV-induced immunosuppression. Keio J Med 2005;54:165-71.

Ullrich SE. Mechanisms underlying UV-induced immune suppression. Mutat Res 2005;571:185-205.

Katiyar SK. UV-induced immune suppression and photocarcinogenesis: Chemoprevention by dietary botanical agents. Cancer Lett 2007;255:1-11.

Mackiewicz-Wysocka M, Bowszyc-Dmochowska M, Strzelecka- Węklar D, Dańczak-Pazdrowska A, Adamski Z. Basal cell carcinoma diagnosis. Contemp Oncol (Pozn) 2013;17:337-42.

Kumar R, Deep G, Agarwal R. An overview of ultraviolet B radiation-induced skin cancer chemoprevention by silibinin. Curr Pharmacol Rep 2015;1:206-15.

Sample A, He YY. Mechanisms and prevention of UV-induced melanoma. Photodermatol Photoimmunol Photomed 2018;34:13-24.

Guy GP Jr, Thomas CC, Thompson T, Watson M, Massetti GM, Richardson LC, et al. Vital signs: Melanoma incidence and mortality trends and projections United States, 1982-2030. MMWR Morb Mortal Wkly Rep 2015;64:591-6.

Schalka S, Steiner D, Ravelli FN, Steiner T, Terena AC, Marçon CR, et al. Brazilian consensus on photoprotection. An Bras Dermatol 2014;89:1-74.

World Health Organization. Ultraviolet Radiation (UV). Available from:

Volkovova K, Bilanicova D, Bartonova A, Letašiová S, Dusinska M. Associations between environmental factors and incidence of cutaneous melanoma. Review. Environ Health 2012;11 Suppl 1:S12.

Engelsen O. The relationship between ultraviolet radiation exposure and Vitamin D status. Nutrients 2010;2:482-95.

Diffey BL. Human exposure to solar ultraviolet radiation. J Cosmet Dermatol 2002;1:124-30.

Cho BA, Yoo SK, Seo JS. Signatures of photo-aging and intrinsic aging in skin were revealed by transcriptome network analysis. Aging (Albany NY) 2018;10:1609-26.

Bosch R, Philips N, Suárez-Pérez JA, Juarranz A, Devmurari A, Chalensouk-Khaosaat J, et al. Mechanisms of photoaging and cutaneous photocarcinogenesis, and photoprotective strategies with phytochemicals. Antioxidants (Basel) 2015;4:248-68.

Kang S, Fisher GJ, Voorhees JJ. Photoaging: Pathogenesis, prevention, and treatment. Clin Geriatr Med 2001;17:643-59, 5-6.

Han A, Chien AL, Kang S. Photoaging. Dermatol Clin 2014;32:291-9, 7.

Sjerobabski Masnec I, Poduje S. Photoaging. Coll Antropol 2008;32 Suppl 2:177-80.

Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety. Clin Interv Aging 2006;1:327-48.

Pamela RD. Topical growth factors for the treatment of facial photoaging: A clinical experience of eight cases. J Clin Aesthet Dermatol 2018;11:28-9.

Pandel R, Poljšak B, Godic A, Dahmane R. Skin photoaging and the role of antioxidants in its prevention. ISRN Dermatol 2013;2013:930164.

Dhaliwal S, Rybak I, Ellis SR, Notay M, Trivedi M, Burney W, et al. Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. Br J Dermatol 2019;180:289-96.

Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol 2002;138:1462-70.

Rabe JH, Mamelak AJ, McElgunn PJ, Morison WL, Sauder DN. Photoaging: Mechanisms and repair. J Am Acad Dermatol 2006;55:1-9.

Rittié L, Fisher GJ. Natural and sun-induced aging of human skin. Cold Spring Harb Perspect Med 2015;5:a015370.

Amano S. Characterization and mechanisms of photoageing-related changes in skin. Damages of basement membrane and dermal structures. Exp Dermatol 2016;25 Suppl 3:14-9.

Driscoll MS, Wagner RF Jr. Clinical management of the acute sunburn reaction. Cutis 2000;66:53-8.

Faurschou A, Wulf HC. Topical corticosteroids in the treatment of acute sunburn: A randomized, double-blind clinical trial. Arch Dermatol 2008;144:620-4.

Feily A, Namazi MR. Aloe vera in dermatology: A brief review. G Ital Dermatol Venereol 2009;144:85-91.

Puvabanditsin P, Vongtongsri R. Efficacy of Aloe vera cream in prevention and treatment of sunburn and suntan. J Med Assoc Thai 2005;88 Suppl 4:S173-6.

Tadicherla S, Berman B. Percutaneous dermal drug delivery for local pain control. Ther Clin Risk Manag 2006;2:99-113.

Das LM, Binko AM, Traylor ZP, Peng H, Lu KQ. Vitamin D improves sunburns by increasing autophagy in M2 macrophages. Autophagy 2019;15:813-26.

Scott JF, Das LM, Ahsanuddin S, Qiu Y, Binko AM, Traylor ZP, et al. Oral Vitamin D rapidly attenuates inflammation from sunburn: An interventional study. J Invest Dermatol 2017;137:2078-86.

Moore DE. Drug-induced cutaneous photosensitivity: Incidence, mechanism, prevention and management. Drug Saf 2002;25:345-72.

Drucker AM, Rosen CF. Drug-induced photosensitivity: Culprit drugs, management and prevention. Drug Saf 2011;34:821-37.

Harth Y, Rapoport M. Photosensitivity associated with antipsychotics, antidepressants and anxiolytics. Drug Saf 1996;14:252-9.

Pile HD, Nicolas D. Isotretinoin. Treasure Island, FL: StatPearls Publishing; 2019.

Hodgkiss-Harlow CJ, Eichenfield LF, Dohil MA. Effective monitoring of isotretinoin safety in a pediatric dermatology population: A novel “patient symptom survey” approach. J Am Acad Dermatol 2011;65:517-24.

Haggan M. Warning on incorrect sunscreen use. Aust J Pharm 2018;

Wang J, Pan L, Wu S, Lu L, Xu Y, Zhu Y, et al. Recent advances on endocrine disrupting effects of UV filters. Int J Environ Res Public Health 2016;13:e782.

Juzeniene A, Moan J. Beneficial effects of UV radiation other than via Vitamin D production. Dermatoendocrinol 2012;4:109-17.

Choi W, Miyamura Y, Wolber R, Smuda C, Reinhold W, Liu H, et al. Regulation of human skin pigmentation in situ by repetitive UV exposure: Molecular characterization of responses to UVA and/or UVB. J Invest Dermatol 2010;130:1685-96.

Brenner M, Hearing VJ. The protective role of melanin against UV damage in human skin. Photochem Photobiol 2008;84:539-49.

Hwang YJ, Park HJ, Hahn HJ, Kim JY, Ko JH, Lee YW, et al. Immediate pigment darkening and persistent pigment darkening as means of measuring the ultraviolet A protection factor in vivo: A comparative study. Br J Dermatol 2011;164:1356-61.

Del Bino S, Duval C, Bernerd F. Clinical and biological characterization of skin pigmentation diversity and its consequences on UV impact. Int J Mol Sci 2018;19:2668.

Holman DM, Fox KA, Glenn JD, Guy GP Jr, Watson M, Baker K, et al. Strategies to reduce indoor tanning: Current research gaps and future opportunities for prevention. Am J Prev Med 2013;44:672-81.

Habbema L, Halk AB, Neumann M, Bergman W. Risks of unregulated use of alpha-melanocyte-stimulating hormone analogues: A review. Int J Dermatol 2017;56:975-80.

Garone M, Howard J, Fabrikant J. A review of common tanning methods. J Clin Aesthet Dermatol 2015;8:43-7.

Ciriminna R, Fidalgo A, Ilharco LM, Pagliaro M. Dihydroxyacetone: An updated insight into an important bioproduct. ChemistryOpen 2018;7:233-6.

Martini MC. Self-tanning and sunless tanning products. Ann Dermatol Venereol 2017;144:638-44.

Give me a tan! Megan Fox. Archives; 2008.

March B. 10 Celebs who look Better Tan-free. COSMOPOLITAN; 2014. 89. Grand View Research. U.S. Sun Care Market Size, Share, Industry

Trends Report; 2018-2025.

Sunscreen Manufacturing Industry in the US. IBISWorld; 2018.

Shetty PK, Venuvanka V, Jagani HV, Chethan GH, Ligade VS, Musmade PB, et al. Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity. Int J Nanomedicine 2015;10:6477-91.

Schneider SL, Lim HW. A review of inorganic UV filters zinc oxide and titanium dioxide. Photodermatol Photoimmunol Photomed 2019;35:442-6.

Moloney FJ, Collins S, Murphy GM. Sunscreens: Safety, efficacy and appropriate use. Am J Clin Dermatol 2002;3:185-91.

Jallad KN. Chemical characterization of sunscreens composition and its related potential adverse health effects. J Cosmet Dermatol 2017;16:353-7.

Moyal D, Chardon A, Kollias N. UVA protection efficacy of sunscreens can be determined by the persistent pigment darkening (PPD) method. (Part 2). Photodermatol Photoimmunol Photomed 2000;16:250-5.

Protecting Your Skin. Chemical vs Physical (Mineral) Sunscreens: Pros and Cons. Blog Dr. Desjarlais; 2016.

Wang SQ, Xu H, Stanfield JW, Osterwalder U, Herzog B. Comparison of ultraviolet A light protection standards in the United States and European Union through in vitro measurements of commercially available sunscreens. J Am Acad Dermatol 2017;77:42-7.

Schalka S, Ravelli FN, Perim N, Vasconcelos R. Chemical and physical sunscreens. In: Issa M, Tamura B, editors. Daily Routine in Cosmetic Dermatology. Clinical Approaches and Procedures in Cosmetic Dermatology. Vol. 1. Cham, Switzerland: Springer; 2017.

Tahiliani S, Shirolikar M. Viva voce on sunscreens. Indian J Drugs Dermatol 2018;4:92-6

National Center for Biotechnology Information. 4-Aminobenzoic Acid, CID=978; 2019.

Kullavanijaya P, Lim HW. Photoprotection. J Am Acad Dermatol 2005;52:937-58.

Begoun P, editor. Avobenzone under fire. In: The Complete Beauty Bible: The Ultimate Guide to Smart Beauty. Ch. 4. Pennsylvania, United States: Rodale; 2004. p. 132.

Lin YC, Lin CF, Alalaiwe A, Wang PW, Fang YP, Fang JY. UV filter entrapment in mesoporous silica hydrogel for skin protection against UVA with minimization of percutaneous absorption. Eur J Pharm Sci 2018;122:185-94.

Ainbinder D, Touitou E. Skin photodamage prevention: State-of-the-art and new prospects. In: Farage MA, Miller KW, Maibach HI, editors. Textbook of Aging Skin. Ch. 44. Berlin, Germany: Springer Science and Business Media; 2009. p. 436.

Govindu PCV, Hosamani B, Moi S, Venkatachalam D, Asha S, John VN, et al. Glutathione as a photo-stabilizer of avobenzone: An evaluation under glass-filtered sunlight using UV-spectroscopy. Photochem Photobiol Sci 2019;18:198-207.

National Center for Biotechnology Information. Avobenzone, CID=51040; 2019.

Nash JF, Tanner PR. Sunscreens. In: Draelos ZD, Thaman LA, editors. Cosmetic Formulation of Skin Care Products Cosmetic Science and Technology. Ch. 9. Milton Park, Didcot: Taylor and Francis; 2005. p. 139.

Aparici-Espert I, Miranda MA, Lhiaubet-Vallet V. Sunscreen-based photocages for topical drugs: Aphotophysical and photochemical study of a diclofenac-avobenzone dyad. Molecules 2018;23:e673.

Yang C, Lim W, Bazer FW, Song G. Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption. Reprod Toxicol 2018;81:50-7.

Uco DP, Leite-Silva VR, Silva HDT, Duque MD, Grice J, Mathor MB, et al. UVA and UVB formulation phototoxicity in a three-dimensional human skin model: Photodegradation effect. Toxicol In vitro 2018;53:37-44.

Monteiro MS, Ozzetti RA, Vergnanini AL, de Brito-Gitirana L, Volpato NM, de Freitas ZM, et al. Evaluation of octyl p-methoxycinnamate included in liposomes and cyclodextrins in anti-solar preparations: Preparations, characterizations and in vitro penetration studies. Int J Nanomedicine 2012;7:3045-58.

National Center for Biotechnology Information. Oxybenzone, CID=4632; 2019.

DiNardo JC, Downs CA. Dermatological and environmental toxicological impact of the sunscreen ingredient oxybenzone/ benzophenone-3. J Cosmet Dermatol 2018;17:15-9.

De Coster S, van Larebeke N. Endocrine-disrupting chemicals: Associated disorders and mechanisms of action. J Environ Public Health 2012;2012:713696.

Fediuk DJ. Pharmacokinetic and Toxicological Characterization of Repellent DEET and Sunscreen Oxybenzone (Thesis Submitted for Ph.D). Available from: bitstream/handle/1993/8112/fediuk_daryl.pdf?sequence=1.

Rao GS, Tokuda H, Ichiishi E, Takasaki M, Iida A, Suzuki N, et al. Oral chemoprevention of skin cancer in mice by benzophenone sunscreens dioxybenzone and octabenzone in drinking water. Anticancer Res 2013;33:2535-40.

Seto Y, Ohtake H, Kato M, Onoue S. Phototoxic risk assessments on benzophenone derivatives: Photobiochemical assessments and dermal cassette-dosing pharmacokinetic study. J Pharmacol Exp Ther 2015;354:195-202.

Heo S, Hwang HS, Jeong Y, Na K. Skin protection efficacy from UV irradiation and skin penetration property of polysaccharide-benzophenone conjugates as a sunscreen agent. Carbohydr Polym 2018;195:534-41.

Sherwood VF, Kennedy S, Zhang H, Purser GH, Sheaff RJ. Altered UV absorbance and cytotoxicity of chlorinated sunscreen agents. Cutan Ocul Toxicol 2012;31:273-9.

Butler TC. Bromal hydrate and chloral hydrate: A pharmacological contrast and its chemical basis. J Pharmacol Exp Ther 1948;94:401-11.

Ngan V. Allergy to Benzophenone. Web DermNet NZ; 2012.

Gunia-Krzyżak A, Słoczyńska K, Popiół J, Koczurkiewicz P, Marona H, Pękala E. Cinnamic acid derivatives in cosmetics: Current use and future prospects. Int J Cosmet Sci 2018;40:356-66.

Rai R, Shanmuga SC, Srinivas C. Update on photoprotection. Indian J Dermatol 2012;57:335-42.

Cinoxate Market is Likely to Witness huge Growth Major Key Players are Parchem(US), Carbosynth Limited(UK), Synchem UG and Co. KG(DE). Market Research Gazette; 2019.

National Center for Biotechnology Information. Octinoxate, CID=5355130; 2019.

Lim HW, Thomas L, Rigel DS. Photoprotection. In: Rigel DS, Weiss RA, Lim HW, Dover JS, editors. Photoaging Basic and Clinical Dermatology. Boca Raton, Florida: CRC Press; 2004.

American Chemical Society. Molecule of the week archive. In: A Few Years, Coral in Hawaiian Waters will no Longer have to put up with us. What molecules are we? Washington, United States: American Chemical Society; 2018.

Siller A, Blaszak SC, Lazar M, Olasz Harken E. Update about the effects of the sunscreen ingredients oxybenzone and octinoxate on humans and the environment. Plast Surg Nurs 2018;38:158-61.

Axelstad M, Boberg J, Hougaard KS, Christiansen S, Jacobsen PR, Mandrup KR, et al. Effects of pre- and postnatal exposure to the UV-filter octyl methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring. Toxicol Appl Pharmacol 2011;250:278-90.

Darbre PD. Environmental oestrogens, cosmetics and breast cancer. Best Pract Res Clin Endocrinol Metab 2006;20:121-43.

National Center for Biotechnology Information. Homosalate, CID=8362; 2019.

Kim TH, Shin BS, Kim KB, Shin SW, Seok SH, Kim MK, et al. Percutaneous absorption, disposition, and exposure assessment of homosalate, a UV filtering agent, in rats. J Toxicol Environ Health A 2014;77:202-13.

Erol M, Çok I, Bostan Gayret Ö, Günes P, Yigit Ö, Sayman E, et al. Evaluation of the endocrine-disrupting effects of homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) in rat pups during the prenatal, lactation, and early postnatal periods. Toxicol Ind Health 2017;33:775-91.

Homosalate. Available from:

Wang Y, Marling SJ, Plum LA, DeLuca HF. Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A 2017;114:8528-31.

Michalun MV, DiNardo JC. Skin Care and Cosmetic Ingredients Dictionary. Boston, Massachusetts: Cengage Learning; 2014.

Levy SB. UV Filters. In: Barel AO, Paye M, Maibach HI, editors. Handbook of Cosmetic Science and Technology. Boca Raton, Florida: CRC Press; 2009.

Rodrigues NDN, Cole-Filipiak NC, Blodgett KN, Abeysekera C, Zwier TS, Stavros VG. Wavepacket insights into the photoprotection mechanism of the UV filter methyl anthranilate. Nat Commun 2018;9:5188.

Wolverton SE, editor. Sunscreen options. In: Comprehensive Dermatologic Drug Therapy. 2nd ed. New York: Elsevier Health Sciences; 2007.

Marks JG Jr., Anderson BE, DeLeo VA, editors. Photoallergens. In: Contact and Occupational Dermatology. Ch. 9. ???: JP Medical Ltd.; 2016.

Avenel-Audran M, Dutartre H, Goossens A, Jeanmougin M, Comte C, Bernier C, et al. Octocrylene, an emerging photoallergen. Arch Dermatol 2010;146:753-7.

de Groot AC, Roberts DW. Contact and photocontact allergy to octocrylene: A review. Contact Dermatitis 2014;70:193-204.

Berkman MS, Yazan Y. Solid lipid nanoparticles: Apossible vehicle for zinc oxide and octocrylene. Pharmazie 2012;67:202-8.

Manová E, von Goetz N, Hungerbühler K. Ultraviolet filter contact and photocontact allergy: Consumer exposure and risk assessment for octocrylene from personal care products and sunscreens. Br J Dermatol 2014;171:1368-74.

Karlsson I, Vanden Broecke K, Mårtensson J, Goossens A, Börje A. Clinical and experimental studies of octocrylene’s allergenic potency. Contact Dermatitis 2011;64:343-52.

Briasco B, Capra P, Mannucci B, Perugini P. Stability study of sunscreens with free and encapsulated UV filters contained in plastic packaging. Pharmaceutics 2017;9:e19.

Blüthgen N, Meili N, Chew G, Odermatt A, Fent K. Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio). Sci Total Environ 2014;476-477:207-17.

Sung CR, Kim KB, Lee JY, Lee BM, Kwack SJ. Risk assessment of ethylhexyl dimethyl PABA in cosmetics. Toxicol Res 2019;35:131-6.

Draelos ZD. Procedures in Cosmetic Dermatology. 2nd ed. New York: Elsevier Health Sciences; 2008.

Bastien N, Millau JF, Rouabhia M, Davies RJ, Drouin R. The sunscreen agent 2-phenylbenzimidazole-5-sulfonic acid photosensitizes the formation of oxidized guanines in cellulo after UV-A or UV-B exposure. J Invest Dermatol 2010;130:2463-71.

Inbaraj JJ, Bilski P, Chignell CF. Photophysical and photochemical studies of 2-phenylbenzimidazole and UVB sunscreen 2-phenylbenzimidazole-5-sulfonic acid. Photochem Photobiol 2002;75:107-16.

Rigel DS, Friedman R, Robinson JK, Ross MI, Cockerell CJ, Lim H, et al. Cancer of the Skin E-Book: Expert Consult. 2nd ed. New York: Elsevier Health Sciences; 2011.

Approved Drug Products and Legal Requirements. Vol. 3. United States: Pharmacopeial Convention, Inc., Thomson Micromedex; 2006.

USP DI: Approved Drug Products and Legal Requirement USP DI. Vol 3. United States: Thomson/MICROMEDEX; 2005.

Lin EW, Boehnke N, Maynard HD. Protein-polymer conjugation via ligand affinity and photoactivation of glutathione S-transferase. Bioconjug Chem 2014;25:1902-9.

Hermanson GT. PEGylation and synthetic polymer modification.In: Hermanson G, editor. Bioconjugate Techniques. 3rd ed., Ch. 18. Boston, MA: Academic Press; 2013. p. 787-838.

US FDA Database. CFR Code of Federal Regulations Title 21.

Lowe NJ. Sunscreens: Development Evaluation, and Regulatory Aspects. 2nd ed. Cosmetic Science and Technology Series. Boca Raton, Florida: CRC Press; 1996.

National Center for Biotechnology Information. Trolamine Salicylate, CID=25213; 2019.

Trolamine Salicylate. Available from: active-ingredients/trolamine-salicylate.

Smijs TG, Pavel S. Titanium dioxide and zinc oxide nanoparticles in sunscreens: Focus on their safety and effectiveness. Nanotechnol Sci Appl 2011;4:95-112.

Trivedi M, Murase J. Titanium dioxide in sunscreen. In: Janus M, editor. Application of Titanium Dioxide. Ch. 4. London: IntechOpen; 2017.

Mohammed YH, Holmes A, Haridass IN, Sanchez WY, Studier H, Grice JE, et al. Support for the Safe use of zinc oxide nanoparticle sunscreens: Lack of skin penetration or cellular toxicity after repeated application in volunteers. J Invest Dermatol 2019;139:308-15.

Wright PFA. Realistic exposure study assists risk assessments of ZnO nanoparticle sunscreens and allays safety concerns. J Invest Dermatol 2019;139:277-8.

Jiang J, Pi J, Cai J. The Advancing of zinc oxide nanoparticles for biomedical applications. Bioinorg Chem Appl 2018;2018:1062562.

Tian L, Lin B, Wu L, Li K, Liu H, Yan J, et al. Neurotoxicity induced by zinc oxide nanoparticles: Age-related differences and interaction. Sci Rep 2015;5:16117.

Tanner PR. Sunscreen product formulation. Dermatol Clin 2006;24:53-62.

Weber C, Podda M, Rallis M, Thiele JJ, Traber MG, Packer L. Efficacy of topically applied tocopherols and tocotrienols in protection of murine skin from oxidative damage induced by UV-irradiation. Free Radic Biol Med 1997;22:761-9.

Raw materials of cosmetics. In: Iwata H, Formulas SK, editors. Ingredients and Production of Cosmetics: Technology of Skin- and Hair-Care Products in Japan. Ch. 2. Berlin, Germany: Springer Science and Business Media; 2012.

Rowe RC, Sheskey PJ, Quinn ME, editors. Alcohol. In: Handbook of Pharmaceutical Excipients. 6th ed. London, United Kingdom: Pharmaceutical Press; 2009. p. 17.

Lachenmeier DW. Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity. J Occup Med Toxicol 2008;3:26.

SD Alcohol 40. Available from:

Romanowski P. Cosmetic Formulation Basics Sunscreens. Available from:

Rattanachaikunsopon P, Phumkhachorn P. Bacteriostatic effect of flavonoids isolated from leaves of Psidium guajava on fish pathogens. Fitoterapia 2007;78:434-6.

National Center for Biotechnology Information. Morin, CID=5281670; 2019.

Beasley DG, Meyer TA. Characterization of the UVA protection provided by avobenzone, zinc oxide, and titanium dioxide in broad-spectrum sunscreen products. Am J Clin Dermatol 2010;11:413-21.

Reef-safe Sunscreen: What you need to Know. Blog CHASING CORAL.

Zirwas MJ, Andrasik W. Can sunscreens harm coral reefs? Addressing environmental concerns and offering practical recommendations. Skinmed 2018;16:223-9.

Belluz J. Hawaii is Banning Sunscreens that Kill Coral Reefs. Vox; 2018.

Danovaro R, Bongiorni L, Corinaldesi C, Giovannelli D, Damiani E, Astolfi P, et al. Sunscreens cause coral bleaching by promoting viral infections. Environ Health Perspect 2008;116:441-7.

Leonardo DiCaprio Foundation. Replenishing Coral Reefs in the Pacific Ocean. Australia: Leonardo DiCaprio Foundation;



How to Cite

AK, M. (2020). AN EXTENSIVE REVIEW ON SUNSCREEN AND SUNTAN PREPARATIONS. Innovare Journal of Health Sciences, 1–21. Retrieved from



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