IN VITRO INTERACTION OF CIPROFLOXACIN AND SOME NATURAL COMPOUNDS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
Objective: This study was designed to determine the effect of combination of some natural compounds with ciprofloxacin (CIP) against methicillin resistant Staphylococcus aureus (MRSA) strains.
Methods: About fifteen (MRSA) strains were selected of patients suffer from different infections. Natural compounds included flavonoids rutin, qurecetin, polyphynolic acids gallic acid, tannic acid, and phenylpropanoids such as 4-hydroxy coumarine, thymol, caffeine and ethyl cinnimate were applied alone and in combination with CIP. Â
Results: Most natural products showed activity against MRSA strains when tested alone. The combination were decreased the activity of CIP. Quercetin and tannic acid were the most effective compounds but rutin, gallic acid, 4-hydroxy comarine, thymol and caffeine had no activity against (MRSA) strains.
Conclusion: The relationship between the natural compounds and CIP was antagonism wherein the compounds had reduced the antibacterial effects of CIP in combination.