FokI POLYMORPHISM OF VITAMIN D RECEPTOR (VDR) GENE ON PULMONARY TUBERCULOSIS PATIENTS IN BALI, INDONESIA

  • I Gusti Ayu Artini Faculty of Medicine Udayana University

Abstract

ABSTRACT

 

Objectives Nowadays tuberculosis still become major health problem in Asian country including Indonesia. The response of tuberculosis treatment is affeccted by many factors including Vitamin D Receptor (VDR) gene polymorphism. Several polymorphism on VDR gene was reported in several studies responsible for treatment response or susceptibility to tuberculosis infection, one of which was FokI polymorphism. The distribution of FokI VDR genotype is highly affected by race and ethnicity. So far there has been no study about this in Bali. Therefore, it is very important to conduct this study to identify the proportion of FokI VDR polymorphism in tuberculosis patients in Bali, Indonesia.

 

Methods This study was a cross sectional study. As many as 35 subjects were selected from adult pulmonary tuberculosis patients who came to pulmonary outpatient clinic of Sanglah Hospital, Bali. Analysis of FokI VDR polymorphism was using PCR/RFLP technique by using restriction enzyme FokI.

 

Results The proportion of FF, Ff, and ff genotype in this study were 20%, 54.3% and 25.7%, respectively.

 

Conclusions The dominant genotype of VDR in pulmonary tuberculosis patients in Bali was Ff.

 

Keywords: FokI polymorphism, vitamin d receptor, susceptibility, treatment, tuberculosis

Author Biography

I Gusti Ayu Artini, Faculty of Medicine Udayana University
Department of Pharmacology and Therapy

References

1. World Health Organization. Global tuberculosis report. Geneva: World Health Organization; 2014.
2. Sutaria N, Liu C, Chen TC. Vitamin D status receptor gene polymorphisms and supplementation on tuberculosis: a systematic review of case control studies and randomized controlled trials. Journal Clinical Translational Endocrinology 2014; 1(4): 151-160.
3. Kementerian Kesehatan Republik Indonesia. Strategi Nasional Pengendalian Tuberkulosis di Indonesia Tahun 2011-2014. Jakarta: Kementerian Kesehatan Republik Indonesia; 2011.
4. Cao Y, Wang X, Cao Z, Cheng X. Association of Vitamin D receptor gene TaqI polymorphisms with tuberculosis susceptibility: a meta-analysis. Int J Clin Exp Med 2015; 8(6): 10187-10203.
5. Junaid K, Rehman A, Saeed T, Jolliffe DA, Wood K, Martineau AR. Genotype-independent association between profound vitamin D deficiency and delayed sputum smear conversion in pulmonary tuberculosis. BMC Infectious Diseases 2015; 15: 275-284.
6. Roth DE, Soto G, Arenas F, Bautista CT, Ortiz J, Rodriguez R, et al. Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis. Journal of Infectious Diseases 2004; 190: 920-927.
7. Sun YP and Cai QS. Vitamin D receptor FokI gene polymorphism and tuberculosis susceptibility: a meta-analysis. Genetics and Molecular Research 2015; 14(2): 6156-6163.
8. Rifat M, Milton AH, Hall J, Oldmeadow C, Islam MA, Husain A, et al. Development of multidrug resistant tuberculosis in Bangladesh: a case-control study on risk factors. Plos One; 9(8): 1-10.
9. Fisher-Hoch SP, Whitney E, McCormick JB, Crespo G, Smith B, Rahbar MH, et al. Type 2 diabetes and mulotidrug resistant tuberculosis. Scand J Infect Dis 2008; 40(11): 888-893.
10. Artini IGA, Artana IGNB, Aman IGM, Mahendra AN. CYP2E1 genotype and transaminase level of tuberculosis patients receiving fixed dose combination of antituberculosis. Bali Medical Journal 2017; 3(3): S70-S74.
11. Artini IGA and Artana IGNB. NAT2 genotype pattern among tuberculosis patients receiving fixed-dose combination of antituberculosis. International Journal of Science and Research 2016; 5(1): 1836-1838.
12. Sinaga BYM, Amin M, Siregar Y, Sarumpaet SM. Correlation between vitamin d receptor gene FokI and BsmI polymorphisms and the susceptibility to pulmonary tuberculosis in an Indonesian Batak-ethnic population. Acta Medica Indonesiana - The Indonesian Journal of Internal Medicine 2014: 275-282.
13. Bid HK, Mishra DK, Mittal RD. Vitamin-D receptor (VDR) gene (Fok-I, Taq-I & Apa-I) polymorphisms in healthy individuals from north Indian population. Asian Pacific Journal of Cancer Prevention 2005; 6: 147-152.
14. Wu F, Zhang W, Zhang L, Wu J, Li C, Meng X, et al. NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis among the chinese kazakh population: a case-control study. BioMed Research International 2013; 1(1):1-8.
15. Rashedi J, Asgharzadeh M, Moaddab SR, Sahebi L, Khalili M, Mazani M, et al. Vitamin d receptor gene polymorphism and vitamin d plasma concentration: correlation with susceptibility to tuberculosis. Adv Pharm Bull 2014; 4(Suppl 2): 607-611.
16. Kang TJ, Jin SH, Yeum C, Lee SB, Kim CH, Lee SH, et al. Vitamin D receptor gene TaqI, BsmI and FokI polymorphisms in Korean patients with tuberculosis. Immune Network 2011; 11(5): 253-257.
17. Joshi L, Ponnana M, Penmetsa SR, Nallari P, Valluri V, Gaddam S. Serum vitamin D levels and VDR polymorphisms (BsmI and FokI) in patients and their household contacts susceptible to tuberculosis. Scandinavian Journal of Immunology 2014; 79: 113–119.
18. Chen C, Liu Q, Zhu L, Yang H, Lu W. Vitamin D receptor gene polymorphisms on the risk of tuberculosis, a meta-analysis of 29 case-control studies. PloS One 2013; 8(12): e83843.
19. Huang L, Liu C, Liao G, Yang X, Tang X, Chen J. Vitamin D receptor gene FokI polymorphism contributes to increasing the risk of tuberculosis: an update metaanalysis. Medicine 2015; 94(51): e2256.
20. Xu C, Tang P, Ding C, Li C, Chen J, Xu Z, et al. Vitamin D receptor gene FokI polymorphism contributes to increasing the risk of HIV-negative tuberculosis: evidence from a meta-analysis. PLoS One 2015; 10(10): 1-13.
21. World Health Organization. Treatment of tuberculosis: Guidelines. 4th edition. Geneva: World Health Organization; 2010.
22. Gunda DW, Nkandala I, Kavishe GA, Kilonzo SB, Kabangila R, Mpondo BC. Prevalence and risk factors of delayed sputum conversion among patients treated for smear positive ptb in northwestern rural tanzania: a retrospective cohort study. Journal of Tropical Medicine 2017: 1-5.
23. Coussens AK, Martineau AR, Wilkinson RJ. Antiinflammatory and antimicrobial actions of vitamin D in combating TB/HIV. Scientifica 2014: 1-13.
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Artini, I. G. A. (2019). FokI POLYMORPHISM OF VITAMIN D RECEPTOR (VDR) GENE ON PULMONARY TUBERCULOSIS PATIENTS IN BALI, INDONESIA. Innovare Journal of Life Sciences, 7(6), 1-3. Retrieved from https://innovareacademics.in/journals/index.php/ijls/article/view/31031
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