TOXICITY ASSESSMENT OF BIOSYNTHESIZED SILVER NANOPARTICLES FROM Solanum villosum Mill. (SOLANACEAE) – In vitro AND in vivo STUDY


Rajendran Venkatesh

Abstract


ABSTRACT

Objective: The aim of the study is evaluation of toxicity assessment of biosynthesized silver nanoparticles from Solanum villosum (Mill.) using in vitro and in vivo study.

Materials and Methods: Biologically synthesized silver nanoparticles are characterized by UV, SEM, EDAX, XRD analysis and its cytotoxicity effect against HepG2cell lines was performed. Further toxicity was confirmed by in vivo studies using wistar albino rats. Various hematological, liver function marker enzymes and liver histopathology are investigated.

The cytotoxic effect of Solanum villosum silver nanoparticles (SV-AgNPs) was also concentration dependent and did not produce any toxicity to tested animals. The histopathological evidence are supported to biochemical observations.

Conclusion: So biologically synthesized silver nanoparticles are toxic only to cancer cells but not in animals were proved by present study.

 

Key Words: SV-AgNPs (Solanum villosum silver nanoparticles), HepG2  cell lines, Scanning electron microscopy (SEM), energy dispersive x-ray spectroscopy (EDAX), X-ray diffraction analysis (XRD).

 


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About this article

Title

TOXICITY ASSESSMENT OF BIOSYNTHESIZED SILVER NANOPARTICLES FROM Solanum villosum Mill. (SOLANACEAE) – In vitro AND in vivo STUDY

Date

01-01-2017

Additional Links

Manuscript Submission

Journal

Innovare Journal of Medical Sciences
Vol 5 Issue 1 2017 (January-February) Page: 15-20

Online ISSN

2321-4406

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85 Views | 115 Downloads

Authors & Affiliations

Rajendran Venkatesh
Department of Biochemistry, kongunadu arts and science college, coimbatore, Tamilnadu, India


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