IMMUNONANOPARTICLES A NOVEL APPROACH FOR CNS DRUG DELIVERY

Abstract

ABSTRACT

Immunoglobulin, commonly known as antibody are natural biological milieu produced from vertebrates, act as therapeutic entities which get initiated with the development of monoclonal antibodies. Using the antibodies as delivery conduits for targeted site, a number of immunotherapeutic agents prevail as the marketed products. At the same time, nano-carriers are one of the versatile, self-engineered and potentially promising, site specific commercialized tool trending in 21^st century. In this overview, a jot down of antibody with pros and cons as well as innovativeness of nanoparticles and nanotechnology has been discussed with a lime light on immunoglobulin and its conjugation with nano-carrier for central nervous system (CNS) delivery system. Since CNS delivery system mainly lacked by the circumvention of Blood Brain Barrier (BBB), a highly protected and secured region where the entry of foreign particles are strictly restricted due to self-controlling security of the highly tactful brain, a need of new approach is a vital issue to overcome all the restrictions. Conjugation of antibody with  nano-carrier representing the immunonanoparticles are new and innovative tool showing efficacy exerting desired biological effects accessing through the BBB. The detail whereabouts of the new tools have been discussed in different form of antibody conjugated nano-architectures with their ease in treating diseases circumventing BBB with in vivo characterization. Thus various immune nano-architectures have been discussed with their potential effect, method of preparation and limitation creating an image of new nano-biological mimetic, effective for site specific delivery with effective biological behaviour and safety profile useful for commercialization economically. 

 

Keywords: Immunonanoparticles, Immunotherapeutics, Biological mimetic.