Conductometric determination of the two angiotensin-converting enzyme (ACE) inhibitors, Ramipril and Enalapril maleate in pure form and in tablets using phosphotungestic acid


Eman Ahmed Bahgat, Afaf Aboul-khier Abdel-monem

Abstract


Simple and sensitive conductometric method has been developed for the determination of Ramipril and Enalapril maleate using phosphotungestic acid in pure form and in tablets. The proposed method  is based on the conductometric determination of 5-20 mg and 7-20 mg of Ramipril and Enalapril maleate by titration with phosphotungstic acid (PTA) in aqueous solution. All the reaction conditions for the proposed methods have been studied. The proposed methods were applied successfully for the determination of Ramipril and Enalapril maleate  in tablets, the RSD values were not exceeding 2 for both drugs. The results obtained were compared statistically with those obtained by the reference method and showed no significant differences regarding accuracy and precision.


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About this article

Title

Conductometric determination of the two angiotensin-converting enzyme (ACE) inhibitors, Ramipril and Enalapril maleate in pure form and in tablets using phosphotungestic acid

Date

01-07-2018

Additional Links

Manuscript Submission

Journal

Innovare Journal of Medical Sciences
Vol 6 Issue 1,2018 (Jan-June) Page: 1-5

Online ISSN

2321-4406

Authors & Affiliations

Eman Ahmed Bahgat
zagazig university
Egypt

Afaf Aboul-khier Abdel-monem
zagazig university
Egypt


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