Pratiti Datta, Pratyay Pratim Datta


Fluorosis is endemic in different parts of the world. The condition may be manifested as dental fluorosis, skeletal fluorosis and other types of fluorosis (non-skeletal fluorosis). Most importance is given to dental fluorosis by the researchers. But, skeletal fluorosis is another form of fluorosis which is often neglected; though this form of fluorosis can cause criplling of a person. In the present study a thorough review has benn undertaken about the prevalence, etiology and clinical features of skeletal fluorosis.

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Azami-Aghdash S, Ghojazadeh M, Azar FP,Naghavi-Behzad M, Mahmoudi M, Zamali Z. Fluoride Concentration of Drinking Waters and Prevalence of Fluorosis in Iran: A Systematic Review. J Dent Res Dent Clin Dent Prospects. 2013 Feb; 7(1): 1–7.

Kotecha PV, Patel SV, Bhalani KD, Shah D, Shah VS, Mehta KG. Prevalence of dental fluorosis & dental caries in association with high levels of drinking water fluoride content in a district of Gujarat, India. Indian J Med Res. 2012 June; 135(6): 873–77.

Choubisa SL. Endemic fluorosis in southern Rajasthan, India. Fluoride. 2001; 34: 61–70.

Bawaskar HS, Bawaskar PH. Endemic fluorosis in an isolated village in western Maharashtra, India. Trop Doct. 2006; 36: 221–23.

Majumdar KK. Health impact of supplying safe drinking water containing fluoride below permissible level on flourosis patients in a fluoride-endemic rural area of West Bengal. Indian J Public Health. 2011 Oct-Dec; 55(4):303-8. doi:10.4103/0019-557X.92411. PubMed PMID: 22298140.

Vuhahula EAM, Masalu JRP, Mabelya L, Wandwi WBC. Dental fluorosis in Tanzania Great Rift Valley in relation to fluoride levels in water and in ‘Magadi’ (Trona) Desalination. 2009; 248: 610–15.

Jiménez-Farfán MD, Hernández-Guerrero JC, Juárez-López LA, Jacinto-Alemán LF, de la Fuente-Hernández J. Fluoride consumption and its impact on oral health. Int J Environ Res Public Health. 2011; 8: 148–60.

Ermiş RB, Koray F, Akdeniz BG. Dental caries and fluorosis in low- and high-fluoride areas in Turkey. Quintessence Int. 2003 May; 34(5):354-60.

Irigoyen ME, Molina N, Luengas I. Prevalence and severity of dental fluorosis in a Mexican community with above-optimal fluoride concentration in drinking water. Community Dent Oral Epidemiol. 1995 Aug;23(4):243-5. PubMed PMID: 7587147.

Hussain J, Hussain I, Sharma KC. Fluoride and health hazards: community perception in a fluorotic area of central Rajasthan (India): an arid environment. Environ Monit Assess. 2010 Mar;162(1-4):1-14. doi: 10.1007/s10661-009-0771-6. PubMed PMID: 19266303.

Choubisa SL, Choubisa L, Choubisa DK. Endemic fluorosis in Rajasthan. Indian J Environ Health. 2001 Oct;43(4):177-89. PubMed PMID: 12395525.

Choubisa SL, Choubisa L, Choubisa D. Osteo-dental fluorosis in relation to age and sex in tribal districts of Rajasthan, India. J Environ Sci Eng. 2010 Jul; 52(3):199-204. PubMed PMID: 21391391.

Pandey A. Prevalence of fluorosis in an endemic village in central India. Trop Doct. 2010 Oct; 40(4):217-19. doi: 10.1258/td.2010.100032. Epub 2010 Aug 20. PubMed PMID: 20729264.

Gopalakrishnan P, Vasan RS, Sarma PS, Nair KS, Thankappan KR. Prevalence of dental fluorosis and associated risk factors in Alappuzha district, Kerala. Natl Med J India 1999;12: 99 –103

Shashi A, Kumar M, Bhardwaj M. Incidence of skeletal deformities in endemic fluorosis. Trop Doct 2008;38:231–33

Krishnamachari KAVR, Krishnamswamy K. Genu valgum and osteoporosis in an area of endemic fluorosis. Lancet 1973;2: 887–89

Bharati P, Rao M. Epidemiology of fluorosis in Dharwad district, Karnataka. J Hum Ecol 2003;14:37–42

Watanabe T, Kondo T, Asanuma S, Ando M, Tamura K, Sakuragi S, Rongdi J, Choake L. Skeletal fluorosis from indoor burning of coal in southestern China. Fluoride 2000; 33: 135–39

Jarvis HG, Heslop P, Kisima J, Gray WK, Ndossi G, Maguire A, Walker RW. Prevalence and aetiology of juvenile skeletal fluorosis in the south-west of the Hai district, Tanzania--a community-based prevalence and case-control study. Trop Med Int Health. 2013 Feb; 18(2):222-9. doi: 10.1111/tmi.12027. PubMed PMID: 23198699.

Huber AC, Mosler HJ. Determining behavioral factors for interventions to increase safe water consumption: a cross-sectional field study in rural Ethiopia. Int J Environ Health Res. 2013;23(2):96-107. doi: 10.1080/09603123.2012.699032. PubMed PMID: 22775759.

Németh L, Zsögön E. Occupational skeletal fluorosis. Baillieres Clin Rheumatol. 1989 Apr;3(1):81-88. Review. PubMed PMID: 2661032.

Krishnamachari KA. Skeletal fluorosis in humans: a review of recent progress in the understanding of the disease. Prog Food Nutr Sci. 1986;10(3-4):279-314. Review. PubMed PMID: 3295994.

Kakumanu N, Rao SD. Images in clinical medicine. Skeletal fluorosis due to excessive tea drinking. N Engl J Med. 2013 Mar 21; 368(12):1140. doi:10.1056/NEJMicm1200995. PubMed PMID: 23514291.

Whyte MP, Totty WG, Lim VT, Whitford GM. Skeletal fluorosis from instant tea. J Bone Miner Res. 2008 May;23(5):759-69. doi: 10.1359/jbmr.080101. PubMed PMID: 18179362.

Bharati P, Kubakaddi A, Rao M, Nack RK. Clinical symptoms of dental and skeletal fluorosis in Gadag and Bagalkot districts of Karnataka. J Hum Ecol 2005; 18:105–07

Susheela AK, Kumar A, Bhatnagar M, Bahadur R. Prevalence of endemic fluorosis with gastrointestinal manifestations in people living in some North-Indian villages. Fluoride 1993;26:97–104

Gupta R, Kumar AN, Bandhu S, Gupta S. Skeletal fluorosis mimicking seronegative arthritis. Scand J Rheumatol. 2007 Mar-Apr;36(2):154-5. PubMed PMID: 17476625.

Chen H, Yan M, Yang X, Chen Z, Wang G, Schmidt-Vogt D, Xu Y, Xu J. Spatial distribution and temporal variation of high fluoride contents in groundwater and prevalence of fluorosis in humans in Yuanmou County, Southwest China. J Hazard Mater. 2012 Oct 15; 235-236:201-9. doi: 10.1016/j.jhazmat.2012.07.042. PubMed PMID: 22910453.

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Innovare Journal of Medical Sciences
Vol 1 Issue 2 2013 (July-September) Page: 5-6

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Authors & Affiliations

Pratiti Datta
Saveetha Dental College, Chennai

Pratyay Pratim Datta
Dept. of Pharmacology, Hi-Tech Medical College and Hospital, Bhubaneswar, India


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