EFFECT OF POTASH ADMINISTRATION ON THE BODY WEIGHT OF PREGNANT WISTAR RATS
Keywords:Potash, Pregnancy, Weight, Wistar rat
Objective: Potash known as potassium carbonate (K2CO3) is a mixture of salt with other components, including impurities which coexist in mineral and salt is highly consumed in various forms by pregnant women. The aim of this research is to determine the effect of potash on the weight index of pregnant Wistar rats.
Methods: A total of 25 albino Wistar rat with weights ranging from 180 to 300 g were used and allocated into five groups of five animals each (four females and one male) designated as Groups A, B, C, D, and E. The experimental Groups B, C, D, and E were administered through oral route different doses of potash of 300 mg/kg, 600 mg/kg, 900 mg/kg, and 1200 mg/kg, respectively, after pregnancy was detected by checking for mucus plug in the vagina. Group A served as the control group and was administered distilled water only. The animals were allowed for 1 week for acclimatization under normal temperature (270–300°C), which they were being fed with normal feed (grower’s mash) and water ad libitum for 1 week.
Results: The result showed a significant (p˂0.05) reduction in weight with the highest level seen with the 1200 mg/kg group when compared to the control.
Conclusion: Therefore, the effect of potash alters the physical activity and decreases weight, by implication may induce growth retardation of the Wistar rats which is not healthy for a pregnant animal.
Mankanjuola AA, Beetlestone JG. Some chemical mineralogical notes on Kaun (Trona). J Min Geol 1975;10:31-41.
Ekanem EJ. A preliminary analysis of samples of Kanwa for sodium, potassium and other minerals. J Biochemical Anal 1997;2:25-43.
Ikwuegbu OA, Gbodi TA, Umo I. Proceeding National Conjugation on Disease of Ruminants. United States: NURI, VOM; 1984. p. 103-120.
International Livestock Centre for Africa. International Livestock Centre for Africa Bulletin Addis Ababa. Nairobi, Kenya: International Livestock Centre for Africa; 1985. p. 22.
Davidson NM, Trevitt L, Parry EH. Peripartum Cardiac Failure. Cardiovascular Disease in Tropics. Vol. 37. London: British Medical Association; 1974. p. 1251.
Uzogara SG, Morton ID, Daniel JW. Quality changes and mineral content of cowpea (Vignia unguiculata L. Warp) seeds processed with Kanwa alkaline salt. J Food Chem 1988;30:1-18.
Ankrah EK, Dovio FE. The properties of Trona and its effect on the cooking time of cowpeas. J Sci Food Agric 1978;29:950-2.
Sodipo OA, Akpan AE, Ajayi OO, Akanji MA. Effect of Normal Consumption of Trona (“Kanwa”) a Local Mineral Salt Lick and Human Erythrocytes-I. Gaborone, Botswana: Abstracts from the 5th International Chemistry Conference in Africa; 1992. p. 36.
Buchanan KM, Purgh, JC. Land and People in Nigeria. 7th ed. London: University of London Press; 1961. p. 44-62.
Alawa N, Judith C, Kwanashie O, Helen L, Prasad SS, Alawa BI. Effects of Natron (Kanwa) varieties on murine virgin uterine contractility. J Pharm 2000;22:1.
Ebadan MI, Obiazi HK, Obodo BN, Aiyeki GE, Ikede RE. Effect of potash on renal profile of albino Wistar rats. Int J Herbs Pharmacol Res 2014;3:75-9.
Guyton AC, Hall JE. The nervous system. In: Textbook of Medical Physiology. London: Saunders Company; 2006. p. 675-701.
Aduema W, Akunneh-wariso C, Vidona WB, Amah AK. Assessment of body weight change and exploratory behavior in mice exposed to powdered tobacco. Int J Med Plants Nat Prod 2019;5:23-8.
Okalie NP, Ikwuchi JC. Cataractogenic potential of bromate-medicated oxidative stress in rabbits. J Med Sci 2004;4:158-63.
Oyewo OO, Onyije FM, Awoniran, PO. Hepatotoxic effect of potassium bromate on the liver of wistar rats. J Morphol Sci 2013;30:107-14.