EFFECT OF POTASH ADMINISTRATION ON THE BODY WEIGHT OF PREGNANT WISTAR RATS
Objective: Potash known as potassium carbonate (K2CO3) is a mixture of salt with other components, including impurities which coexist in mineral and salt is highly consumed in various forms by pregnant women. The aim of this research is to determine the effect of potash on the weight index of pregnant Wistar rats.
Methods: A total of 25 albino Wistar rat with weights ranging from 180 to 300 g were used and allocated into five groups of five animals each (four females and one male) designated as Groups A, B, C, D, and E. The experimental Groups B, C, D, and E were administered through oral route different doses of potash of 300 mg/kg, 600 mg/kg, 900 mg/kg, and 1200 mg/kg, respectively, after pregnancy was detected by checking for mucus plug in the vagina. Group A served as the control group and was administered distilled water only. The animals were allowed for 1 week for acclimatization under normal temperature (270–300°C), which they were being fed with normal feed (grower’s mash) and water ad libitum for 1 week.
Results: The result showed a significant (p˂0.05) reduction in weight with the highest level seen with the 1200 mg/kg group when compared to the control.
Conclusion: Therefore, the effect of potash alters the physical activity and decreases weight, by implication may induce growth retardation of the Wistar rats which is not healthy for a pregnant animal.
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