COMPARISON BETWEEN BROMINE, CALCIUM, CHLORINE, IODINE, POTASSIUM, MAGNESIUM, MANGANESE, AND SODIUM CONTENTS IN MACRO- AND MICRO-FOLLICULAR COLLOID GOITER
Keywords:Macro- and micro-follicular colloid nodular goiter of thyroid, Intact thyroid, Chemical elements, Instrumental neutron activation analysis
Objective: Colloid nodular goiter (CNG) is the most common disease of the thyroid, even in non-endemic regions, but the etiology of CNG is unclear. It is known that not merely iodine (I) but other chemical elements (ChE) are involved in goitrogenesis. The current study was performed to clarify the preferential accumulation of some ChE either in the colloid or in cells of the thyroid gland.
Methods: Eight ChE: Bromine, calcium, chlorine (Cl), I, potassium, magnesium, manganese, and sodium (Na) in the thyroid tissues with diagnosed CNG were prospectively evaluated in 16 patients with macrofollicular CNG and 13 patients with microfollicular CNG. The control group included thyroid tissue samples from 105 healthy individuals. Measurements were conducted using non-destructive instrumental neutron activation analysis with high-resolution spectrometry of short-lived radionuclides.
Results: It was found that in macrofollicular CNG, the mass fraction of Cl and Na was 2.57 and 1.82 times, respectively, higher than in tissues of the normal thyroid. In microfollicular CNG, the mass fraction of I was 59% lower, whereas the mass fraction of Na was 67% higher than in tissues of the normal thyroid. The level of I in macrofollicular goiter was 2.08 times higher than in microfollicular goiter
Conclusion: There are substantial changes in ChE contents in the goitrous transformed tissue of the thyroid, which depend on the histology of the goiter.
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