COMPARISON BETWEEN BROMINE, CALCIUM, CHLORINE, IODINE, POTASSIUM, MAGNESIUM, MANGANESE, AND SODIUM CONTENTS IN MACRO AND MICRO FOLLICULAR COLLOID GOITER
Keywords:Macro- and micro follicular colloid nodular goiter of thyroid; Intact thyroid; Chemical elements; Instrumental neutron activation analysis.
Objective: Colloid nodular goiter (CNG) is the most common disease of the thyroid, even in non-endemic regions, but an etiology of CNG is unclear. It is known that not only iodine (I) but other chemical elements (ChE) are involved in goitrogenesis. The present study was performed to clarify the preferential accumulation of some ChE either in the colloid or in cells of the thyroid gland.
Methods: Eight ChE: bromine (Br), calcium (Ca), chlorine (Cl), I, potassium (K), magnesium (Mg), manganese (Mn), and sodium (Na) in the thyroid tissues with diagnosed CNG were prospectively evaluated in 16 patients with macro-follicular CNG and 13 patients with micro-follicular CNG. Control group included thyroid tissue samples from 105 healthy individuals. Measurements were performed using non-destructive instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides (INAA-SLR).
Results: It was found that in macro-follicular CNG the mass fraction of Cl and Na was 2.57 and 1.82 times, respectively, higher than in tissues of the normal thyroid. In micro-follicular CNG the mass fraction of I was 59% lower, whereas the mass fraction of Na was 67% higher than in tissues of the normal thyroid. The level of I in macro-follicular goiter was 2.08 times higher than in micro-follicular goiter
Conclusions: There are considerable changes in ChE contents in the goitrous transformed tissue of thyroid, which depend on the histology of goiter.
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