ALOE VERA POWDER BASED MATRIX TABLET FOR ORAL CONTROLLED DELIVERY OF HIGHLY SOLUBLE DRUG
Abstract
This study mainly aimed for oral control delivery system of highly water soluble drug using aloe vera powder as a carrier for matrix tablet. Ascorbic acid is taken as a model drug for its high solubility. Different concentrations such as 30 %, 40 % and 50 % of matrix tablets of Aloe Vera powder are made by wet granulation technique using starch paste as a binder. The formulated granules were further subjected to Quality control test such as Angle of repose (º), Bulk Density, Carr's Index and Hausner ratio. These matrix tablets are then subjected to in vitro drug release using USP dissolution apparatus. The amount of ascorbic acid released from the matrix is estimated by using UV spectrometer and this result is compared with marketed ascorbic acid tablets. Formulation containing 40 % matrix was found to be good as compared to other two formulations and shows better controlled release of drug.References
Krishnaiah Y.S.R KarthikeyanR.S (2002) A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprololtartrate.InternationalJournal of Pharmaceutics 241 353–366.
Sankar V Ramakrishna B Karthik S (2012) Oral Disintegration Tablets of Stavudine for HIV Management: A New Technological Approach. Indian Journal of Pharmaceutical Sciences 74(6) 556-563.
Craik, D.J (1958).The flow properties of starch powders andmixtures. J. Pharm. Pharmacol. 10, 73.
Krishnaiah, Y.S.R., Satyanarayana, S., Rama Prasad, Y.V.,NarasimhaRao, S., (1998) Gamma scintigraphic studies on aloe vera matrix tablets for colon-specific drug deliveryin healthy subjects. J. Controlled Release 55, 245–252.
Yasuda K et al (2005). Biomechanical properties of high-toughness double network hydrogels. Biomaterials; 26: 4468-4475.
Subramanian K, Narmadha S, Vishnupriya U, VijayakumarV (2010). Release characteristics of Aspirin and Paracetamol drugs from tablets with Aloe vera gel powder as a drug carrier. Drug Invention Today ; 2(9): 424-428.
Train, D., (1958). Some aspects of the property of angle of repose of powders. J. Pharm. Pharmacol. 10, 127T–135T.
Kumar R, Patil MB, Patil SR (2009); Formulation and Evaluation of effervescent of floating tablets of famotidine.International journal of Pharma Tech research 1(3): 754-763.
Hwang, RC, Peck, GR, Besserman, DM, Friedrich, CE. andGemoules, MK.(2000) Tablet relaxation and physicomechanical stability of lactose, microcrystalline cellulose, and dibasic calcium phosphate. Pharmaceutical Technology, 3, 112-132.
Kalu VD, Odeniyi MA, JaiyeobaKT (2002). Matrix properties of a new plant gums in controlled drug delivery. Arch Pharm Res, 30, 7, 884-889.