ANTIMICROBIAL ACTIVITY AND CHARACTERIZATION OF SEVEN SYNTHETIC FORMAMIDINE DISULFIDE DERIVATIVES

Abstract

The amine-formamidine disulfide (FMD), a product of the oxidation of thiourea is reacted with seven different aldehydes to yield corresponding formamidine disulfide Schiff bases, each of which possesses the characteristic C=N. The synthetic compounds were characterized by infra-red (IR) spectrum, mass spectrum (MS), ¹³CNMR and ¹HNMR. The antimicrobial activity was tested against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The least antimicrobial activity was exhibited by 3,4,5-Trimethoxy FMD Schiff base while Anisaldehyde FMD, 3-Nitro FMD, Cinnamaldehyde FMD and Vanillin FMD all show better and comparable antimicrobial activity relative to the other Schiff bases synthesized as reported.