• ACHARYULU MN Department of Basic Sciences and Humanites, Centurion University of Technology and Management, Gidijala, Andhra Pradesh, India.
  • MOHANA RAO PVSR Department of Engineering Chemistry, A. U. College of Engineering(A), Visakhapatnam, Andhra Pradesh, India,
  • SIVA RAMA KOTI I Department of Basic Sciences and Humanites, Centurion University of Technology and Management, R. Sitapur, Odisha, India.


Objective: A simple and sensitive extractive visible spectrophotometric method is developed for the assay of triprolidine hydrochloride using sodium nitroprusside.

Methods: Based on color development with amino groups, presence, which is basic, may be due to the formation of inner complex replacing H2O by the tertiary amino group present in the drug.

Results: The colored products exhibit absorption λmax at 447 nm. Regression analysis of Beer–Lambert plots showed good correlation in the concentration ranges (40–240) μg/ml and correlation coefficients are 0.994. The Sandell’s sensitivities 2.6373×10−2 (1 mole cm−1) and molar absorptivity value are 1.1938×104 (g cm−2). Recovery studies are found to be 99.708–99.786.

Conclusion: The method can be applied successfully for the estimation of the drug in the presence of other ingredients that are usually present in formulations.

Keywords: Tertiary amino group, Inner complex, Regression analysis


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