BI-GELS: A NOVEL MATERIAL FOR TRANSDERMAL DRUG DELIVERY

  • SARIPILLI RAJESWARI Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, India. http://orcid.org/0000-0003-1131-9132
  • RAJESWARI PULLABHATLA Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, India.
  • CHUKKA YERNI SATYAVATHI Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, India.

Abstract

Bi-gels semi solid formulation is combination of organogel and hydrogel with better application property such as pharmaceutical and cosmetics. The main objective of this review is specially focuses on application of bi-gels as drug delivery vehicles by transdermal route. It contains two different phases which are polar and nonpolar due to which, it possess some significant features such as ability to deliver the hydrophilic and hydrophobic drugs which also have improved permeability of drugs, better spreading ability, and water wash ability. Hence, bigels have both organogels and hydrogels they can enhanced hydration of stratum corneum and also had an ability to manipulate the drug release rate from the dosage from.

Keywords: Bi-gels, Hydrogels, Organogels, Transdermal drug delivery

Author Biography

SARIPILLI RAJESWARI, Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, India.

Pharmaceutical Technology

References

1. Zheng H, Mao L, Cui M, Liu J, Gao Y. Development of food-grade bi-gels based on ?-carrageenan hydrogel and monoglyceride oleogels as carriers for ?-carotene: Roles of oleogel fraction. Food Hydrocolloid 2020;2020:105855.
2. Mukherjee S, Ash D, Majee SB, Biswas GR. Studies on span based soy bi-gels with HPMC. Res J Pharm Technol 2020;13:353-60.
3. Khelifi I, Saada M, Hayouni EA, Tourette A, Bouajila J, Ksouri R. Development and characterization of novel bi-gel-based 1, 4-naphthoquinones for topical application with antioxidant potential. Arab J Sci Eng 2020;45:53-61.
4. Singh VK, Qureshi D, Nayak SK, Pal K. Bigels. In: Polymeric Gels. Vol. 1. Sawston: Wood Head Publishing; 2018. p. 265-82.
5. Kodela SP, Pandey PM, Nayak SK, Uvanesh K, Anis A, Pal K. Novel agar-stearyl alcohol oleogel-based bigels as structured delivery vehicles. Int J Polym Mater 2017;66:669-78.
6. Behera B, Singh VK, Kulanthaivel S, Bhattacharya MK, Paramanik K, Banerjee I, et al. Physical and mechanical properties of sunflower oil and synthetic polymers based bigels for the delivery of nitroimidazole antibiotic-a therapeutic approach for controlled drug delivery. Eur Polym J 2015;64:253-64.
7. Lupi FR, Shakeel A, Greco V, Rossi CO, Baldino N, Gabriele D. A rheological and microstructural characterisation of bigels for cosmetic and pharmaceutical uses. Mater Sci Eng C 2016;69:358-65.
8. Singh V, Banerjee I, Agarwal T, Pramanik K, Bhattacharya MK, Pal K. Guar gum and sesame oil based novel bigels for controlled drug delivery. Colloid Surf B Biointerfaces 2014;123:582-92.
9. Lupi FR, Gentile L, Gabriele D, Mazzulla S, Baldino N, De Cindio B. Olive oil and hyperthermal water bigels for cosmetic uses. J Colloid Interf Sci 2015;459:70-8.
10. Fekete T, Borsa J. Polysaccharide-based polymer gels. In: Polymer Gels, Gels Horizons: Sciences to Smart Materials. Vol. 1., Ch. 5. Singapore; Springer; 2018. p. 147-8.
11. Lin HR, Hsu CY, Lo YL. Preparation and characterization of dual phase transition oral hydrogel for sustained release of epirubicin. Int J Polym Biomater 2013;62:763-9.
12. Rehman K, Zulfakar MH. Recent advances in gel technologies for topical and transdermal drug delivery. Drug Dev Ind Pharm 2014;40:433-40.
13. Otto W, Drahoslav L. Hydrophilic gels in biologic use. Nature 1960;185:117-8.
14. Lupi FR, Shakeel A, Greco V, Baldino N, Calabro V, Gabriele D. Organogelation of extra virgin olive oil with fatty alcohols, glyceryl stearate and their mixture. LWT Food Sci Technol 2017;77:422-9.
15. Lupi FR, Gabriele D, Greco V, Baldino N, Seta L, De Cindio B. A rheological characterization of an olive oil/fatty alcohols organogel. Food Res Int 2013;51:510-7.
16. Ogutcu M, Y?lmaz E. Characterization of hazelnut oil oleogels prepared with sunflower and carnauba waxes. Int J Food Prop 2015;18:1741-55.
17. Bollom MA, Clark S, Acevedo NC. Development and characterization of a novel soy lecithin-stearic acid and whey protein concentrate bigel system for potential edible applications. Food Hydrocolloids 2020;101:1055-70.
18. Schaink HM, Van Malssen KF, Morgado-Alves S, Kalnin D, Van der Linden E. Crystal network for edible oil organogels: Possibilities and limitations of the fatty acid and fatty alcohol systems. Food Res Int 2007;40:1185-93.
19. Kumar R, Katare OP. Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review. AAPS PharmSciTech 2005;6:E298-310.
20. Dassanayake LS, Kodali DR, Ueno S, Sato K. Physical properties of rice bran wax in bulk and organogels. J Am Oil Chem Soc 2009;86:1163.
21. Sawalha H, Venema P, Bot A, Flöter E, van der Linden E. The influence of concentration and temperature on the formation of ?-oryzanol+ ?-sitosterol tubules in edible oil organogels. Food Biophys 2011;6:20-5.
22. Mallia VA, George M, Blair DL, Weiss RG. Robust organogels from nitrogen-containing derivatives of (R)-12-hydroxystearic acid as gelators: Comparisons with gels from stearic acid derivatives. Langmuir 2009;25:8615-25.
23. Suzuki M, Nanbu M, Yumoto M, Shirai H, Hanabusa K. Novel dumbbell-form low-molecular-weight gelators based on L-lysine: Their hydrogelation and organogelation properties. New J Chem 2005;29:1439-44.
24. Shakeel A, Farooq U, Gabriele D, Marangoni AG, Lupi FR. Bigels and multi-component organogels: An overview from rheological perspective. Food Hydrocolloids 2020;10:1061-90.
25. Zhao W, Li Y, Sun T, Yan H, Hao A, Xin F, et al. Heat-set supramolecular organogels composed of ?-cyclodextrin and substituted aniline in N, N-dimethylformamide. Colloids Surf A Physicochem Eng Aspect 2011;374:115-20.
26. Wassén S, Bordes R, Gebäck T, Bernin D, Schuster E, Lorén N, et al. Probe diffusion in phase-separated bicontinuous biopolymer gels. Soft Matter 2014;10:8276-87.
27. Yu G, Yan X, Han C, Huang F. Characterization of supramolecular gels. Chem Soc Rev 2013;42 6697-722.
28. Singh VK, Anis A, Banerjee I, Pramanik K, Bhattacharya MK, Pal K. Preparation and characterization of novel carbopol based bigels for topical delivery of metronidazole for the treatment of bacterial vaginosis. Mater Sci Eng C 2014;44:151-8.
29. Rehman K, Amin MC, Zulfakar MH. Development and physical characterization of polymer-fish oil bigel (hydrogel/oleogel) system as a transdermal drug delivery vehicle. J Oleo Sci 2014:ess14101.
30. Sreekumar M, Mathan S, Mathew SS, Dharan SS. Bigels: An updated review. J Pharm Sci Res 2020;12 1306-8.
31. Souza RL, Faria E, Figueiredo R, Fricks A. Use of polyethylene glycol in the process of sol-gel encapsulation of Burkholderia cepacia lipase. J Therm Anal Calorimetry 2014;117:301-6.
32. Pal R. Electromagnetic, Mechanical, and Transport Properties of Composite Materials. Boca Raton, Florid: CRC Press; 2014.
33. Singh VK, Sagiri SS, Pal K, Khade SM, Pradhan DK, Bhattacharya MK. Gelatin-carbohydrate phase-separated hydrogels as bioactive carriers in vaginal delivery: preparation and physical characterizations. J Appl Polym Sci 2014;131:40445.
34. Behera B, Sagiri SS, Singh VK, Pal K, Anis A. Mechanical properties and delivery of drug/probiotics from starch and non-starch based novel bigels: A comparative study. Starch-Stärke 2014;66:865-79.
35. Behera B, Dey S, Sharma V, Pal K. Rheological and viscoelastic properties of novel sunflower oil-span 40-biopolymer based bigels and their role as a functional material in the delivery of antimicrobial agents. Adv Polym Tech 2015;34:21488.
36. Sahoo S, Sing VK, Biswal D, Anis A, Rana UA, Al-Zahrani S, et al. Development of ionic and non-ionic natural gum-based bigels: Prospects for drug delivery application. J Appl Polym Sci 2015;132:42561.
37. Behera B, Sagiri SS, Pal K, Pramanik K, Rana UA, Shakir I, et al. Sunflower oil and protein-based novel bigels as matrices for drug delivery applications characterization and in vitro antimicrobial efficiency. Polym Plast Technol Eng 2015;54:837-50.
38. Ibrahim MM, Hafez SA, Mahdy MM. Organogels, hydrogels and bigels as transdermal delivery systems for diltiazem hydrochloride. Asian J Pharm Sci 2013;8:48-57.
39. Satapathy S, Singh VK, Sagiri SS, Agarwal T, Banerjee I, Bhattacharya MK, et al. Development and characterization of gelatin-based hydrogels, emulsion hydrogels, and bigels: A comparative study. J Appl Polym Sci 2015;132:41502.
40. Sagiri SS, Singh VK, Kulanthaivel S, Banerjee I, Basak P, Battachrya MK, et al. Stearate organogel-gelatin hydrogel based bigels: Physicochemical, thermal, mechanical characterizations and in vitro drug delivery applications. J Mech Behav Biomed Mater 2015;43:1-7.
41. Singh VK, Anis A, Al-Zahrani S, Pradhan DK, Pal K. Molecular and electrochemical impedance spectroscopic characterization of the carbopol based bigel and its application in iontophoretic delivery of antimicrobials. Int J Electrochem Sci 2014;9:5049-60.
42. Wakhet S, Singh VK, Sahoo S, Sagiri SS, Kulanthaivel S, Bhattacharya MK, et al. Characterization of gelatin–agar based phase separated hydrogel, emulgel and bigel: A comparative study. J Mater Sci Mater Med 2015;26:118.
43. Rehman K, Zulfakar MH. Novel fish oil-based bigel system for controlled drug delivery and its influence on immune modulatory activity of imiquimod against skin cancer. Pharm Res 2017;34:36-48.
44. Andonova VY, Peneva PT, Apostolova EG, Dimcheva TD, Peychev ZL, Kassarova MI. Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels. Trop J Pharm Res 2017;16:1455-63.
45. Velichka A, Petya P, George SG, Vencislava TT. Ketoprofen loaded polymer carriers in bigel formulation: An approach to enhancing drug photostability in topical application forms. Int J Nanomed 2017;12:6221-38.
46. Charyulu RN, Muaralidharan A, Sandeep DS. Design and evaluation of bigels containing flurbiprofen. Res J Pharm Technol 2018;11:143-52.
47. Fang JY, Hwang TL, Fang CL. In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug. Int J Pharm 2003;255:153-66.
48. Hamed R, AbuRezeq AA, Tarawneh O. Development of hydrogels, oleogels, and bigels as local drug delivery systems for periodontitis. Drug Dev Ind Pharm 2018;44:1488-97.
49. Paul SR, Qureshi D, Yogalakshmi Y, Nayak SK, Singh VK, Syed I, et al. Development of bigels based on stearic acid-rice bran oil oleogels and tamarind gum hydrogels for controlled delivery applications. J Surf Deterg 2018;21:17-29.
50. Mazurkeviciute A, Ramanauskiene K, Ivaskiene M, Grigonis A, Briedis V. Topical antifungal bigels: Formulation, characterization and evaluation. Acta Pharm 2018;68:223-33.
51. Hamed R, Abu A, Tarawneh RO. Development of hydrogels, oleogels, and bigels as local drug delivery systems for periodontitis. Drug Dev Ind Pharm 2018;44:1488-97.
52. Martín-Illana A, Notario-Pérez F, Cazorla-Luna R, Ruiz-Caro R, Veiga MD. Smart freeze-dried bigels for the prevention of the sexual transmission of HIV by accelerating the vaginal release of tenofovir during intercourse. Pharmaceutics 2019;11:232.
53. Shakeel A, Lupi FR, Gabriele RD, Baldino N, De Cindio B. Bigels: A unique class of materials for drug delivery applications. Soft Mater 2018;16:77-93.
54. Ahmad S, Francesca RL, Domenico G. Bigels: A unique class of materials for drug delivery applications. Soft Mater 2018;16:1-30.
55. Ahmad S, Ujala F, Tanveer I. Key characteristics and modelling of bigel systems: A review. Mater Sci Eng C 2019;19:932-53.
56. Shibayama M, Tanaka T. Phase transition and related phenomena of polymer gels. Adv Polym Sci 1993;1:1-62.
57. Sagiri SS, Behara B, Rafanan R. Organogels as matrices for controlled drug delivery: A review on the current state. Soft Mater 2014;12:47-72.
Statistics
24 Views | 27 Downloads
Citations
How to Cite
RAJESWARI, S., PULLABHATLA, R., & SATYAVATHI, C. Y. (2021). BI-GELS: A NOVEL MATERIAL FOR TRANSDERMAL DRUG DELIVERY. Innovare Journal of Sciences, 9(2), 1-5. https://doi.org/10.22159/ijs.2021.v9i2.40674
Section
Review Article(s)