FORMULATION AND EVALUATION OF HYDROGEL WITH ASCORBIC ACID USING ALOE VERA GEL POWDER AS A DRUG CARRIER
Objective: The aim of this study is to develop a controlled release hydrogel and to evaluate the efficiency of its drug delivery. Even though the synthetic polymer drug carriers will be safely metabolized, they will not impart any health benefit unlike the natural carriers such as starch and Aloe vera. Hence, in the present investigation in vitro release characteristics of ascorbic acid based hydrogel formulated using Aloe vera gel powder as a drug carrier and nutrient fortifying excipient has been used.
Methods: Hydrogel is a recent approach of sustained drug delivery which is advantageous because of its unique drug release patterns like swelling and diffusion. Vitamin C is a well known antioxidant which scavenges free radicals and Aloe vera enhances the bioavailability of vitamin C which is also protecting it from degradation along with its other essential properties.
Results: Various evaluation parameters have been carried out such as swelling studies and in vitro release studies. These evaluation studies results have shown that maximum swelling percentage was seen at pH 1.4 and least in distilled water which imparts that even in acidic medium the formulated hydrogel can outlive. Appreciable swelling was seen in pH 5.4 and 7.4. Furthermore, the hydrogel was seen to undergo disintegration in distilled water.
Conclusion: The in vitro release studies showed that the drug was released at a pre-determined rate over a controlled period of time hence it can be used in sustained drug delivery. The materials used in this study are bio available and biocompatible hence will not impart any toxicity and side-effects.
1. Shaikh Rahamathullah. Design and evaluation of controlled release layered matrix tablets of Paracetamol and Verapamil HCl. Masters Thesis, Universiti Sains Malaysia, 2009.
2. Brondsted H, Kopecek J, Harland RS, Prudâ€™homme RK Eds. In Polyelectrolyte Gels. ACS Symposium Series 480. American Chemical Society. Washington, DC, 1992; Chapter 17.
3. Kunal Pal, Banthia AK and Majumdar DK. Starch based hydrogel with potential biomedical application as artificial skin. African Journal of Biomedical Research 2006; 9: 23-29
4. Yasuda K et al., Biomechanical properties of high-toughness double network hydrogels. Biomaterials 2005; 26: 4468-4475.
5. Gramlich G, Zhang J, Nau WM. Increased Antioxidant Reactivity of Vitamin C at low pH in Model Membranes. J. Am. Chem. Soc. 2002; 124: 11252-11253.
6. Eshun K, He Q. Aloe vera: A valuable ingredient for the food, pharmaceutical and cosmetic industries. A review, Crit. Rev. Food Sci. Nutr. 2004; 44: 91-96.
7. Shelton RM. Aloe vera: Its chemical and therapeutic properties. Int. J. Dermatol. 1991; 30: 679- 683.
8. Madan J, Sharma AK, Singh R. Fast Dissolving Tablets of Aloe Vera Gel. Trop. J. Pharm. Res. 2009; 8(1): 63-70.
9. Hamman HH. Composition and applications of Aloe Vera gel. Molecules 2008; 13: 1599-1616.
10. Cascone MG, Barbani N, Cristallini C, Giusti P, Ciardelli G and Lazzeri L. Bioartificial polymeric materials based on polysaccharides. Journal of Biomaterials Science, Polymer (2001); 3(12): 267â€“281.
11. Choi S, Chung, MH. A review on the relationship between Aloe vera components and their biologic effects. Semin. Integr. Med. 2003; 1: 53-62.
12. Subramanian K, Narmadha S, Vishnupriya U, Vijayakumar V. Release characteristics of Aspirin and Paracetamol drugs from tablets with Aloe vera gel powder as a drug carrier. Drug Invention Today 2010; 2(9): 424-428.
13. Government of India. Ministry of Health and Social Welfare. Indian Pharmacopoeia. The Controller of Publication, New Delhi; 1996.
14. Pal K, Banthia AK, Majumdar DK. Preparation and Characterization of Polyvinyl Alcoholâ€“Gelatin Hydrogel Membranes for Biomedical Applications. AAPS PharmSciTech. 2007; 8(1): E142-E146.