PREVALENCE OF METABOLIC SYNDROME AND ITS COMPONENTS IN WOMEN WITH SUBCLINICAL HYPOTHYROIDISM
Abstract
Objective: Thyroid dysfunction was found to be more common among women with metabolic syndrome. A cross-sectional analysis showed that subjects with subclinical hypothyroidism (SH) had high prevalence of cardiovascular disease than euthyroid subjects. The objective of the current study is to evaluate the prevalence of metabolic syndrome and cardiovascular risk factors among subclinical  hypothyroid subjects. Methods:  Thirty untreated subclinical hypothyroid women and thirty normal healthy subjects were recruited for the study. Fasting blood samples were collected for lipid profile, glucose and insulin level estimation. Results: Fasting plasma glucose, total cholesterol, triglycerides and LDL-cholesterol were found to be significantly increased in SH patients Both systolic and diastolic blood pressures were higher in the patient group. 43.3 percent of the SH patients were found to satisfy the criteria for metabolic syndrome. Conclusion: In our study, subclinical hypothyroidism is significantly associated with metabolic syndrome and its components. Whether this association might be translated into a compounded cardiovascular risk needs to be evaluated by further studies.
Key Words: Subclinical hypothyroidism, metabolic syndrome, cardiovascular risk.
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References
Subclinical Thyroid Disease. Scientific review and guidelines for diagnosis and management. JAMA 2004;291: 228-38.
Diez JJ, Iglesias P. Spontaneous subclinical hypothyroidism in patients older than 55 years, an analysis of nature, course and risk factor for the development of overt thyroid failure. J Clin Endocrinol Metab. 2004;89: 4890-7.
Grundy SM. Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds. J Am Coll Cardiol. 2006;47: 1093-1100.
Nima V Thakkar, Sunita M Jain. Assessment of the metabolic profile in patients of type 2 Diabetes mellitus and hypothyroidism through comet assay. Asian J Pharm Clin Res. 2011;Vol 4(1): 66-71.
Gaurav Agarwal, Sudhakar MK, Mohini Singh, Senthil N, Amarabalan Rajendran. The prevalence of thyroid dysfunction among south Indian women with metabolic syndrome. JCDR 2011 Apr, Vol-5(2): 152-154.
Uzunlulu M, Yorulmaz E, Oguz A. Prevalence of subclinical hypothyroidism in patients with metabolic syndrome. Endocrin J. 2007;54: 71-76.
Tkac I. Metabolic syndrome in relationship to type 2 diabetes and atherosclerosis. Diabetes Res Clin Pract. 2005;68 (suppl): S2-9.
Walsh JP, Brenner AP, Bulsara MK, O'Leary P, Leedman PJ, Feddema P. Subclinical thyroid dysfunction as a risk factor for cardiovascular disease. Arch Intern Med. 2005;165: 2467-72.
McDermott MT, Ridgway EC. Subclinical hypothyroidism is mild thyroid failure and should be treated. J Clin Endocrinol Metab. 2001;86: 4585-90.
Duntas LH. Thyroid disease and lipids. Thyroid. 2002;12: 287-293.
Caraccio N, Ferrannini E, Monzani F. Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study. J Clin Endocrinol Metab. 2002;87(4): 1533-1538.
Luboshitzky R, Herer P. Cardiovascular risk factors in middle-aged women with subclinical hypothyroidism. Neuroendocrinology Letters. 2004;25(4): 262-266.
Kventy J, Heldgaard PE, Bladbejerg EM. Subclinical hypothyroidism is associated with low grade inflammation, increased triglyceride levels and predicts cardiovacular disease in males below 50 years. Clin Endocrinol. 2007;61: 232-238.
Sundaram V, Hanna AN, Koneru L, Newman HAI, Falko JM. Both hypothyroidism and hyperthyroidism enhance low density lipoprotein oxidation. J Clin Endocrinol Metab. 1997;82: 3421-3424.
Asvold BO, Vatten LJ, Nilsen TI, Bjoro T. The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study. Eur J Endocrinol. 2007;156(6): 707-712.
Tuzcu A, Bahceci M, Gokalp D, Tuzun Y, Gunes K. Subclinical hypothyroidism may be associated with high sensitive C-reactive protein (low grade inflammation) and fasting hyperinsulinemia. Endocr J. 2005;52: 89-94.
Asvold BO, Bjoro T, Nilsen TI, Vatten VJ. Association between blood pressure and serum thyroid-stimulating hormone concentration within the reference range: a population based study. J Clin Endocrinol Metab. 2007;92: 841-845.
Poonguzhali DV, Vinodhini VM, Ebenezer William, Kumar JS. Evaluation of Apolipoprotein-B levels in Dysglycemia. Asian J Pharm Clin Res. 2013; Vol6(3):112-114.
Dimitriadis G, Mitrou P, Lambadiari V. Insulin action in adipose tissue and muscle in hypothyroidism. J Clin Endocrinol Metab. 2006;91: 4930-4937.
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