PROTECTIVE ROLE, IN -VITRO FREE RADICAL SCAVENGING ACTIVITIES OF ALANGIUM SALVIFOLIUM (LINN) AGAINEST CCL4 INDUCED HEPATIC DAMAGE IN RATS
Keywords:
Hepatoprotective activity, Antioxidant activity, Alangium salvifolium, Silymarin, CCl4Abstract
Many hepatoprotective herbal preparations have been recommended in an alternative system of medicine for the treatment of hepatic disorders. There are few or no systemic studies have been done on the protective efficacy of Alangium salvifolium (Alangiaceae) to treat liver diseases. Hepatoprotective and antioxidant activity of ethanolic extracts were evaluated against CCl4-induced liver damage in rats. Liver damage was evidenced by elevated levels of biochemical parameters such as serum glutamate oxaloacetic acid transaminase, glutamate pyruvic transaminase and serum alkaline phosphatase. Treatment with ethanolic extracts of Alangium salvifolium (300,500mg/kg, p. o.) produced a significant reversal in the above biochemical parameters, and reducing power, superoxide anion scavenging activity and reduced histopathological scores. These findings suggest that extracts of Alangium salvifolium possess significant hepatoprotective and antioxidant properties.
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