THERAPEUTIC POTENTIAL OF CICHORIUM INTYBUS IN LIFESTYLE DISORDERS: A REVIEW
Abstract
ABSTRACT
The genus Cichorium (Asteraceae) is comprised six species, widely cultivated in Europe and Asia. Cichorium intybus (common name- chicory) is
used as a coffee substitute. However, its leaves, flowers, seeds, and roots have been customarily utilized as home grown solution for various ailments
since ancient times. Although commercialized as coffee substitute, C. intybus is also used in indigenous system of medicine to treat different ailments
from wounds to diabetes. Several numbers of chemical constituents of chicory have been identified, and a significant number of these constituents
have not been fully investigated for their pharmacological potential. Toxicological information on chicory is also limited. This review targets on the
socially imperative medicinal use of chicory in lifestyle disorders. The pharmacological activities of this plant in lifestyle disorders, phytochemical
composition (active compounds) isolated from chicory plant with medicinal importance and safety studies are discussed in detail.
Keywords: Cichorium intybus, Insulin resistance, Chicory extract, Non-alcoholic fatty liver disease.
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References
REFERENCES
Cragg GM, Newman DJ, Snader KM. Natural products in drug
discovery and development. J Nat Prod 1997;60(1):52-60.
European Medicines Agency. Assessment Report on Cichorium
intybus L., Radix, EMA/HMPC/113041/2010; 2013.
Judzentiene A, Udien JB. Volatile constituents from aerial parts and
roots of Cichorium intybus L. (chicory) grown in Lithuania. Chemija
;19:25-8.
Table 1: Contd...
Chemical constituents Part used/Type of extract Medicinal importance References
*CQA, DCQA Seeds/ethanolic extract Improve glycemic,
Chicoric acid, Cinnamic acid and Caftaric acid (trace) Seeds/aqueous extract Amelioration of diabetes
and *NAFLD
Caffeic acid, Quinic acid, Caffeoylquinic acid, Caftaric acid,
Quercetin-, Kaempferol, 5-O-feruloyquinic acid, Dicaffeoyltartaric
acid (chicoric acid), Cyanidin, 4-O-feruloyquinic acid,
Apigenin-7-O-glucoside, Chrysoeriol-3-O-glucoside, -Dicaffeoylquinic
acid, Myricetin-7-O-(600-O-malonyl)-glucoside,
Dimethoxycinnamoyl shikimic acid, Kaempferol-3-O-sophoroside,
Isorhamnetin-7-O-glucoside, Chlorogenic acid, Malic acid
Atherogenic index and
Antioxidant status
Leaves/methanolic extract Caffeic acid and cinnamic
acid ameliorate glucose
metabolism[31]
Chlorogenic acid exhibits
anti-obesity property
and improves lipid
metabolism [64]
Oxalic, Succinic, Shikimic and Quinic acids Leaves/aqueous extract Inhibit virulence - of
oral pathogens including
Streptococcus mutans,
Actinomyces naeslundii and
Prevotella intermedia
(7S, 8R)-3O-Demethyl-, dehydrodiconiferyl
alcohol-3-O-β-glucopyranoside, 3,5-Crepidiaside A
Root Not stated [66]
Chicoric acid Aerial part of chicory/
hydro-alcoholic extract
*CCl
: Carbon tetra chloride, CQA: 5-Caffeyolquinic acid, DCQA: Dicaffeyolquinic acid, NAFLD: Nonalcoholic fatty liver disease
Anti-hyperglycemic effect
due to enhance the insulin
release and glucose uptake
Ghamarian A, Abdollahi M, Su X, Amiri A, Ahadi A, Nowrouzi A. Effect
of chicory seed extract on glucose tolerance test (GTT) and metabolic
profile in early and late stage diabetic rats. Daru 2012;20(1):56.
Kaskoos RA. Anti-diabetic activity of Cichorium intybus seeds on
STZ-induced diabetic rats. Int Res J Pharm 2012;3(5):161-4.
Schumacher E, Vigh E, Molnár V, Kenyeres P, Fehér G, Késmárky G,
et al. Thrombosis preventive potential of chicory coffee consumption:
A clinical study. Phytother Res 2011;25(5):744-8.
Jurgonski A, Juskiewicz J, Zdunczyk Z, Król B. Caffeoylquinic
acid-rich extract from chicory seeds improves glycemia, atherogenic
index, and antioxidant status in rats. Nutrition 2012;28(3):300-6.
Ahmad B, Siddiqui AB, Alam T, Alam SA. Components from seed of
Cichorium intybus Linn. Indian J Chem 2002;41B(12):2701-5.
Anonymous. Standardisation of Single Drugs of Unani Medicine.
Part I. New Delhi: CCRUM; 1987. p. 156-61.
Muthusamy VS, Anand S, Sangeetha KN, Sujatha S, Arun B,
Lakshmi BS. Tannins present in Cichorium intybus enhance glucose
uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B
inhibition. Chem Biol Interact 2008;174(1):69-78.
Rub RA, Siddiqui R, Ali AM, Shaikh A, Mukadam M. Screening of
antioxidant and antidiabetic potential of polyphenol rich fraction from
Cichorium intybus. Pharmacognosy J 2014;6(4):92-8.
Kim M, Shin HK. The water-soluble extract of chicory reduces glucose
uptake from the perfused jejunum in rats. J Nutr 1996;126(9):2236-42.
Pushparaj PN, Low HK, Manikandan J, Tan BK, Tan CH. Anti-diabetic
effects of Cichorium intybus in streptozotocin-induced diabetic rats.
J Ethnopharmacol 2007;111(2):430-4.
Tousch D, Lajoix AD, Hosy E, Azay-Milhau J, Ferrare K, Jahannault C,
et al. Chicoric acid, a new compound able to enhance insulin release
and glucose uptake. Biochem Biophys Res Commun 2008;377:131-5.
Samarghandian S, Borji A, Tabasi SH. Effects of Cichorium intybus
Linn on blood glucose, lipid constituents and selected oxidative stress
parameters in streptozotocin-induced diabetic rats. Cardiovasc Hematol
Disord Drug Targets 2013;13:231-6.
Ziamajidi N, Khaghani S, Hassanzadeh G, Vardasbi S, Ahmadian S,
Nowrouzi A, et al. Amelioration by chicory seed extract of diabetes- and
oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/
non-alcoholic steatohepatitis (NASH) via modulation of PPARa and
SREBP-1. Food Chem Toxicol 2013;58:198-209.
Nishimura M, Ohkawara T, Kanayama T, Kitagawa K, Nishimura H,
Nishihira J. Effects of the extract from roasted chicory (Cichorium
intybus L.) root containing inulin-type fructans on blood glucose,
lipid metabolism, and fecal properties. J Tradit Complement Med
;5:161-7.
Li GY, Gao HY, Huang J, Lu J, Gu JK, Wang JH. Hepatoprotective effect
Asian J Pharm Clin Res, Vol 9, Issue 3, 2016, 20-25
Chandra and Jain
of Cichorium intybus L. a traditional Uighur medicine, against carbon
tetrachloride-induced hepatic fibrosis in rats. World J Gastroenterol
;20(16):4753-60.
Gadgoli C, Mishra SH. Antihepatotoxic activity of Cichorium intybus.
J Ethnopharmacol 1997;58(2):131-4.
Helal E, Samia M, Atef M, Ghada A. Effect of Cichorium intybus L. on
fatty liver induced by oxytetracyclin in albino rats. Egypt J Hosp Med
;45:522-35.
Asl ZS, Malekirad AA, Abdollahi M, Bakhshipour A, Dastjerdi HA,
Mostafalou S, et al. Effect of the mixture of Cichorium intybus L. and
Cinnamomum zeylanicum on hepatic enzyme activity and biochemical
parameters in patients with non-alcoholic fatty liver disease. Health
;6:1212-7.
Saggu S, Sakeran MI, Zidan N, Tousson E, Mohan A, Rehman H.
Ameliorating effect of chicory (Chichorium intybus L.) fruit extract
against 4-tert-octylphenol induced liver injury and oxidative stress in
male rats. Food Chem Toxicol 2014;72:138-46.
Neha M, Katare P, Deepshikha VA, Amitesh K, Vidushi J, Alka M, et al.
Determination of antioxidant and hepatoprotective ability of flavonoids
of Cichorium intybus. Int J Toxicol Pharmacol Res 2014;6:107-12.
Al-Malki AL, Abo-Golayel MK. Hepatoprotective efficacy of chicory
alone or combined with dandelion leaves against induced liver damage.
Life Sci J 2013;10(4):140-57.
Belal NM. Hepatoprotective effect of feeding celery leaves mixed with
chicory leaves and barely grains to hypercholesteramic rats. Asian J
Clin Nutr 2011;10:3923.
Jamshidzadeh A, Khoshnood MJ, Dehghani Z, Niknahad H.
Hepatoprotective activity of Cichorium intybus leaves extract against
carbon tetrachloride induced toxicity. Iran J Pharm Res 2006;1:41-6.
Fathalla N, Bishr M, Singab AN, Salama O. Phytochemical and
biological evaluation of Cichorium intybus L. seeds. IOSR-JPBS
;10:70-6.
Ahmed B, Khan S, Masood MH, Siddique AH. Anti-hepatotoxic
activity of cichotyboside, a sesquiterpene glycoside from the seeds of
Cichorium intybus. J Asian Nat Prod Res 2008;10(3-4):223-31.
Zafar R, Mujahid Ali S. Anti-hepatotoxic effects of root and root callus
extracts of Cichorium intybus L. J Ethnopharmacol 1998;63:227-31.
Cha JY, Park CK, Cho YS. Hepatoprotective effect of chicory
(Cichorium intybus) root extract against orotic acid-induced fatty liver
in rats. Food Sci Biotechnol 2010;19:865-71.
El-Sayed YS, Lebda MA, Hassinin M, Neoman SA. Chicory
(Cichorium intybus L.) root extract regulates the oxidative status and
antioxidant gene transcripts in CCl4-induced hepatotoxicity. PLoS One
;10:e0121549.
Hassan HA, Yousef MI. Ameliorating effect of Chicory (C. intybus)
supplemented diet against nitrosamine precursors-induced liver injury
and oxidative stress in male rats. Food Chem Toxicol 2010;48:2163-9.
Lante A, Nardi T, Zocca F, Giacomini A, Corich V. Evaluation of red
chicory extract as a natural antioxidant by pure lipid oxidation and
yeast oxidative stress response as model systems. J Agric Food Chem
;59(10):5318-24.
Lavelli V. Antioxidant activity of minimally processed red
chicory (Cichorium intybus L.) evaluated in xanthine oxidase-,
myeloperoxidase-, and diaphorase-catalyzed reactions. J Agric Food
Chem 2008;56:7194-200.
Ali W. Antihyperglycemic effect of Chicory leaves and Vanadium
composition on diabetic experimental rats. World J Dairy Food Sci S
;7:167-73.
Nayeemunnisa and Kumuda Rani M. Cardio protective effect of
Cichorium intybus in aging Myocardium of albino rats. Curr Sci
;84:941-3.
Kim M. The water soluble extract of chicory affects rat intestinal
morphology similarly to other non-starch polysaccharide. Nutr Res
;22:1299-307.
Devdi L, Morroni F, Lombardi-boccia G, Lucarini M, Hrelia P,
Cantelli-forti G, Tarozzi A. Red Chicory (Cichorium intybus L. cultivar)
as a potential source of antioxidant, anthocyanins for intestinal health.
Oxid Med Cell Longev 2013;2013:Article ID: 704310, 8.
Papetti A, Mascherpa D, Carazzone C, Stauder M, Spratt DA,
Wilson M, et al. Identification of organic acids in Cichorium intybus
inhibiting virulence-related properties of oral pathogenic bacteria. Food
Chem 2013;138(2-3):1706-12.
Cavin C, Delannoy M, Malnoe A, Debefve E, Touché A, Courtois D,
et al. Inhibition of the expression and activity of cyclooxygenase-2 by
chicory extract. Biochem Biophys Res Commun 2005;327(3):742-9.
Rizvi W, Fayazuddin M, Shariq S, Singh O, Moin S, Akhtar K, et al.
Anti-inflammatory activity of roots of Cichorium intybus due to its
inhibitory effect on various cytokines and antioxidant activity. Anc Sci
Life 2014;34(1):44-9.
Ahmed LA, Ramadan RS, Mohamed RA. Biochemical and
histopathological studies on the water extracts of Marjoram and chicory
herbs and their mixture in obese rats. Pak J Nutr 2009;8:1581-7.
Kim M. The water-soluble extract of chicory reduces cholesterol uptake
in gut-perfused rats. Nutr Res 2000;20:1017-26.
Saleem M, Abaas K, Nasser F, Ahmad M, Sayed NH, Javed F,
et al. Anticancer activity of n-hexane extract of Cichorium intybus
on lymphoblastic leukemia cells (jurkat cells). Afr J Plant Sci
;8:315-9.
Karimi MH, Ebrahimnezhad S, Namayandeh M, Amirghofran Z. The
effects of cichorium intybus extract on the maturation and activity of
dendritic cells. Daru 2014;22(1):28.
Olsen NJ, Branch VK, Jonnala G, Seskar M, Cooper M. Phase 1,
placebo-controlled, dose escalation trial of chicory root extract in
patients with osteoarthritis of the hip or knee. BMC Musculoskelet
Disord 2010;11:156.
Bridle P, Thomas RS, Timberlake CF, Self R. Cyanidin
-malonylglucoside in Cichorium intybus. Phytochemistry
;23:2968-9.
Monde K, Oya T, Shirata A, Takatsuki M. A guaianolide
phytoalexin, cichoralexin, from Cichorium intybus. Phytochemistry
;29:3449-51.
Gilani AH, Janbaz KH, Shah BH. Esculetin prevents liver damage
induced by paracetamol and CCL4. Pharmacol Res 1998;37(1):31-5.
Atta-ur-Rahman, Zareen S, Choudhary MI, Akhtar MN, Khan SN.
Alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium
intybus. J Nat Prod 2008;71:910-3.
Krebsky EO, Geuns JM, De-Proft M. Polyamines and steroids in
Cichorium heads. Phytochemistry 1999;50:49-553.
Cho AS, Jeon SM, Kim MJ, Yeo J, Seo KI, Choi MS, et al.
Chlorogenic acid exhibits anti-obesity property and improves lipid
metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol
;48(3):937-43.
Clifford MN. Chlorogenic acid and other cinnamats-nature occurrence,
dietary burden, absorption and metabolism. J Sci Food Agric
;80:1033-43.
Wesolowska A, Nikiforuk A, Michalska K, Kisiel W, Chojnacka-Wójcik
E. Analgesic and sedative activities of lactucin and some lactucin-like
guaianolides in mice. J Ethnopharmacol 2006;107(2):254-8.
Kisiel W, Zielinska K. Guaianolides from Cichorium intybus and
structure revision of Cichorium sesquiterpene lactones. Phytochemistry
;57(4):523-7.
Pyrek JS. Sesquiterpene lactones of Cichorium intybus and Leontodon
autumnalis. Phytochemistry 1985;24:186-8.
Gray DE, Robert CA, Rottinghaus GE, Garrett HE, Pallardy SG.
Quantification of root chicoric acid in purple cone flower by near
infrared reflectance spectroscopy. Crop Sci 2001;41:1159-61.
Nørbaek R, Nielsen K, Kondo T. Anthocyanins from flowers of
Cichorium intybus. Phytochemistry 2002;60:357-9.
Gürbüz I, Ustün O, Yesilada E, Sezik E, Akyürek N. In vivo
gastroprotective effects of five Turkish folk remedies against
ethanol-induced lesions. J Ethnopharmacol 2002;83:241-4.
Bischoff TA, Kelley CJ, Karchesy Y, Laurantos M, Nguyen-Dinh P, Arefi
AG. Antimalarial activity of lactucin and lactucopicrin: Sesquiterpene
lactones isolated from Cichorium intybus L. J Ethnopharmacol
;95(2-3):455-7.
Nandgopal S, Ranjitha-Kuamari BD. Phytochemical and antibacterial
studies of Chicory (Cichorium intybus L) – A multipurpose plant. Adv
Biol Res 2007;1:17-21.
Mulabagal V, Wang H, Ngouajio M, Nair MG. Characterization and
quantification of health beneficial anthocynin in leaf Chicory varieties.
Eur Food Res Technol 2009;230:47-53.
Milala J, Grzelak K, Król B, Juśkiewicz J, Zduńczyk Z. Composition
and properties of chicory extracts rich in fructans and polyphenols. Pol
J Food Nutr Sci 2009;59(1):35-43.
Montefusco A, Semitaio G, Marrese PP, Iurlaro A, De Caroli MD, Piro G,
et al. Antioxidants in varieties of chicory (Cichorium intybus L.) and
wild poppy (Papaver rhoeas L.) of Southern Italy. J Chem 2015;Article
ID: 923142. http://dx.doi.org/10.1155/2015/92314.
Carazzone C, Mascherpa D, Gazzani G, Papetti A. Identification of
phenolic constituents in red chicory salads (Cichorium intybus) by
high-performance liquid chromatography with diode array detection
and electrospray ionisation tandem mass spectrometry. Food Chem
;138(2-3):1062-71.
Malarz J, Stojakowskaa A, Sznelerb E, Kisiel W. A new neolignan
Asian J Pharm Clin Res, Vol 9, Issue 3, 2016, 20-25
Chandra and Jain
glucoside from hairy roots of Cichorium intybus. Phytochem Lett
;6:59-61.
Azay-Milhau J, Ferrare K, Leroy J, Aubaterre J, Tournier M, Lajoix AD,
et al. Antihyperglycemic effect of a natural chicoric acid extract of
chicory (Cichorium intybus L.): A comparative in vitro study with the
effects of caffeic and ferulic acids. J Ethnopharmacol 2013;150:755-60.
Schmidt BM, Ilic N, Poulev A, Raskin I. Toxicological evaluation of a
chicory root extract. Food Chem Toxicol 2007;45:1131-9.
Ilaiyaraja N, Khanum F. Evaluation of antioxidant and toxicological
properties of Chicory leaves. Int J Pharm Biol Arch 2010;1:155-63.
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