DETERMINATION OF EFFICACY OF A NATURAL TABLET BINDER: CHARACTERIZATION AND IN- VITRO RELEASE STUDY
The objective of the study concerns the evaluation of gum Odina as a novel pharmaceutical aid for the development of tablet formulation. The tablet weight (850mg) and thickness (8mm) was kept constant. Paracetamol was used as reference drug. Wet granulation technique was used for the preparation of Paracetamol granules. The binder concentrations used in the formulation were 0.125%, 0.250%, and 0.375%. The prepared powder mixtures were subjected to both pre and post compression evaluation parameters including; IR spectroscopy, Micromeritics, tablet hardness, friability, disintegration time and in-vitro drug release. Compatibility of the drug with the gum was studied using FTIR. The results of micromeritics studies revealed that all formulations wereÂ Â good flowability. Tablet hardness and friability indicated good mechanical strength. In vitro dissolution studies indicated that the release of drug from tablet with 0.125% gum odina was 98.55% in 30 minute but release was delayed with 0.25% and 0.375% gum odina. It is concluded that the gum odina requires less amount as a tablet binder than starch with complying all parameters.
Keywords: Gum Odina, Tablet binder, Paracetamol, Wet granulation, In-vitro drug release.
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