EFFECT OF PHARMACOLOGICAL DOSES OF GARLIC AND OMEGA 3 ON GASTRIC LESIONS INDUCED BY ETHANOL IN MICE
DOI:
https://doi.org/10.22159/ajpcr.2016.v9i5.12833Abstract
Objective: This work was designed to investigate and compare the possible protective effect of pharmacological doses of garlic and omega 3 against
gastric lesions induced by ethanol in mice.
Methods: A total of 30 mice involved in the study were divided into five groups with 6 mice for each. Groups 1 (ulcer control) and 2 (normal control),
Groups 3 (positive ulcer control treated with ranitidine 50 mg/kg), Groups 4 and 5 treated with garlic oil and omega 3 oil at doses 200 and 150 mg/kg,
respectively. All groups treated orally by gastric gavage once daily for 14 days before starting gastric ulcer (GU) induction process by absolute ethanol
administration.
Results: A treatment with garlic and omega 3 ameliorated the severity of gastric ulceration evidenced by reduced ulcer index area, increase %
gastroprotection, increase mucus content, reduced erosions, and necrosis.
Conclusion: Oral administration of pharmacological doses of garlic oil and omega 3 oil shows significant gastroprotection against GU models induced
by absolute ethanol confirmed by biochemical and histological data.
Keywords: Gastric ulcer, Garlic, Omega 3, Gastroprotection.
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References
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