• Mishra Sk
  • Rout K
  • Prusty Sk
  • Pratap Kumar Sahu Siksha O Anusandhan University, Bhubaneswar, Odisha


Objective: To evaluate the nootropic activity of methanolic extract of pre-shodhit and shodhit Semecarpus anacardium (SA) nuts and to observe the
effect of shodhana on nootropic activity of SA.
Methods: Spatial learning and working memory was considered for evaluation. The parameters used were spontaneous alternation behavior
(Y-maze), number of correct responses (radial maze), and transfer latency in day 1 (elevated plus maze). Scopolamine, an anticholinergic drug, was
used to induce cognitive deficit. % inhibition of acetylcholine esterase (AChE) was measured in vitro.
Results: Both pre-shodhit and shodhit drug reversed the scopolamine-induced a decrease in percentage spontaneous alternation behavior in Y-maze
and number of correct responses in radial maze. Scopolamine-induced increase in transfer latency in elevated plus maze was significantly decreased
by pre-shodhit drug only. Shodhit drug has no significant effect on transfer latency. Both pre-shodhit and shodhit drug showed dose-dependent
inhibition of AChE activity in vitro. Pre-shodhit drug showed a more nootropic activity than shodhit drug.
Conclusion: Methanolic extract of the nuts of S. anacardium possesses nootropic activity which may be attributed to inhibition of cholinesterase
activity. Shodhana of the nuts decreases nootropic activity.
Keywords: Semecarpus anacardium, Acetylcholine esterase, Shodhana, Nootropic.

Author Biography

Pratap Kumar Sahu, Siksha O Anusandhan University, Bhubaneswar, Odisha

Associate Professor

Dept of Pharmacology


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How to Cite
Sk, M., R. K, P. Sk, and P. K. Sahu. “SHODHANA DECREASES NOOTROPIC ACTIVITY OF SEMECARPUS ANACARDIUM”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 8, Oct. 2016, pp. 294-7, doi:10.22159/ajpcr.2016.v9s2.13989.
Original Article(s)