STUDY OF HEPATITIS B VIRUS INFECTION AND ITS GENOTYPES IN TRIBAL PEOPLE


Johra Khan, Amal Alotaibi

Abstract


Objective: This study was undertaken to screen the epidemiology of hepatitis B virus (HBV) in ethnically distinct, tribal dominated and of lower
socioeconomic status area.

Methods: Briefly, 3 ml blood was collected from 50 random liver disease cases with jaundice, receiving care at Central Hospital, N.F. Railway, Guwahati,
and Guwahati Medical College, with informed consent. The patients detected with hepatitis A virus (HAV)-immunoglobulin M positive status were
included and were stratified as acute viral hepatitis and fulminant hepatitis failure based on the clinical profile. HAV genotyping was studied by
polymerase chain reaction-direct sequencing-phylogenetic analysis approach. Statistical analysis was performed using SPSS 13.0 software.

Result: A total of 50 cases were HBV infected. HBV infection was predominant in the young and adult age group. HBV-RNA was detected in 19 cases.

Conclusion: This study shows that HBV genotype D is most commonly found hepatitis in all tribes of Assam and poor sanitation and alcohol
consumption are a common reason for its widespread.

Keywords: Genotype, Hepatitis B virus, Liver disease, Molecular epidemiology, Phylogenetic study.


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About this article

Title

STUDY OF HEPATITIS B VIRUS INFECTION AND ITS GENOTYPES IN TRIBAL PEOPLE

DOI

10.22159/ajpcr.2017.v10i4.14087

Date

01-04-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 4 April 2017 Page: 51-55

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

114 Views | 70 Downloads

Authors & Affiliations

Johra Khan

Amal Alotaibi


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