PHYTOCHEMICAL PROFILING AND EFFICACY EVALUATION OF ANTIBACTERIAL POTENTIAL OF MYRISTICA FRAAGRANS SEED EXTRACTS AGAINST SELECTED MICROORGANISMS
Introduction: Traditional plants have been proved as novel source for health care remedies. Plants are the rich source of bioactive compounds which can be useful for health care purpose. Emergence of resistance among pathogenic bacteria against available antibiotics is a common phenomenon. So the plant based bioactive molecule may be an alternative for the development of new formulation. The use of natural bioactive molecules as parental compound for development of new formulation may be safer with less side effects as compared to synthetic chemical compounds. Myristica fraagrans seed are widely used in routine life from ancient time for health care. Traditionally it is being used in for stomach related complications. So the current study pertained to the phytochemical profiling of Myristica fraagrans seed and its efficacy evaluation against some clinically significant bacterial species.
Methods: Â In this study ethanol and acetone extract of Myristica fraagrans seed (Jaiphal) were prepared via using soxhlet apparatus. Extract were qualitatively analysed to check the phytochemical composition. Then antibacterial efficacy of prepared extracts were analysed by agar well diffusion assay against Escherichia coli, Bacillus subtilis, Bacillus Magetarium, Proteus mirabilis.
Results: The result of phytochemical profiling shows the presence of tannin, terpenoids, alkaloids, indole and phenol. Moreover Myristica fraagrans seed extract exhibiting significant antibacterial activity against selected microorganisms.
Conclusion: Finding of the study concludes that Myristica fragrans seed ( jiphal )Â possess the antimicrobial capabilities against infections and/or diseases caused by chosen microorganisms and seems to be useful in the discovery of novel antibiotic drugs.
KEY WORDS: Myristica fraagrans (Jaiphal), Escherichia coli., Bacillus subtilis, Bacillus Magetarium, Proteus mirabilis., antibacterial activity etc.
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