THE OUTCOME OF CEFUROXIME VERSUS METRONIDAZOLE AS SURGICAL PROPHYLAXIS FOR HYSTERECTOMY - A RETROSPECTIVE STUDY IN A SOUTH INDIAN SETUP

  • Roya Rozati HOD, PROFESSOR DEPT OF OBGYN
  • Fatima Tahniyath clinical pharmacist,MHRT
  • Mehdi AG MBBS
  • Aiman VA MBBS
  • Saman Fatima MS
  • Divya Chowdary G MS

Abstract

Objective: To evaluate the outcome of cefuroxime and metronidazole as surgical prophylactic measure for hysterectomy procedures in a South Indian setup.

Methods: A retrospective study was conducted in 60 women who underwent hysterectomy and was prescribed metronidazole and cefuroxime. The data regarding demographic details, presenting complaints, parity, obstetrics history, diagnosis, and need for hysterectomy were evaluated.

Results: A total of 148 women admitted with hysterectomies performed were taken into consideration of which 68 were prescribed cefuroxime and metronidazole alone but 8 patients did not respond to treatment and were given other antibiotics, hence 60 patients formed the study population. The mean age was 20±05.29 years. Patients above 51 years were mostly seen. Uterovaginal prolapse was very commonly observed, anemia (mild=7) was the main risk factor found, cefuroxime was commonly prescribed compared to metronidazole, and febrile episodes were commonly noticed. One-way ANOVA revealed the F ratio to be 6.04, p value calculated as 0.06 significant at p≤0.10.

Conclusion: In our study, cefuroxime appeared to be effective in prophylaxis against infections. Metronidazole appeared to be ineffective compared to cefuroxime.

Keywords: Antibiotic, Surgical prophylaxis, Hysterectomy, Infections.

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Rozati, R., F. Tahniyath, M. AG, A. VA, S. Fatima, and D. C. G. “THE OUTCOME OF CEFUROXIME VERSUS METRONIDAZOLE AS SURGICAL PROPHYLAXIS FOR HYSTERECTOMY - A RETROSPECTIVE STUDY IN A SOUTH INDIAN SETUP”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 1, Jan. 2017, pp. 262-7, doi:10.22159/ajpcr.2017.v10i1.15122.
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