EFFECT OF SODIUM VALPROATE AND DOCOSAHEXAENOIC ACID ON INFLAMMATION IN RATS

  • Sushil Kiran Kunder Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka
  • Laxminarayana Kurady Bairy Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka http://orcid.org/0000-0002-1828-6946
  • Avinash A Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka

Abstract

Objective: To evaluate the anti-inflammatory activity of sodium valproate and docosahexaenoic acid (DHA) supplementation using various experimental models in albino Wistar rats.

Method: A total of 48 adult Wistar albino male rats were divided into 8 groups of 6 rats each. Group I was control (distilled water 1 ml/kg), Group II received intraperitoneal (i.p.) injection of indomethacin (10 mg/kg), Groups III-V were injected (i.p.) with sodium valproate 100, 200, and 400 mg/kg water, and Groups VI-VIII were given sodium valproate 100, 200, and 400 mg/kg plus DHA 300 mg/kg (i.p.), respectively. Anti-inflammatory activity was assessed using carrageenan induced paw edema and the cotton pellet granuloma models.

Results: We found that higher doses of sodium valproate (400 mg/kg) used either alone or with a combination of DHA (300 mg/kg) showed a significant anti-inflammatory activity when compared to control in both the models of inflammation.

Conclusion: Combination of sodium valproate along DHA has shown promising anti-inflammatory activity.

Keywords: Anti-inflammatory drugs, Sodium valproate, Rat model.

Author Biographies

Sushil Kiran Kunder, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka
Postgraguate, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka
Laxminarayana Kurady Bairy, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka
Department of Pharmacology, kasturba Medical College, Manipal University, Manipal.
Avinash A, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka
Postgraduate, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka

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Kunder, S. K., L. K. Bairy, and A. A. “EFFECT OF SODIUM VALPROATE AND DOCOSAHEXAENOIC ACID ON INFLAMMATION IN RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 1, Jan. 2017, pp. 286-9, doi:10.22159/ajpcr.2017.v10i1.15207.
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