ELECTROCHEMICAL OXIDATION AND DETERMINATION OF AN ANTI-CANCER DRUG PEMETREXED DISODIUM


Nagaraj P Shetti

Abstract


Abstract-The electrochemical oxidation of an anti-cancer drug Pemetrexed disodium has been investigated at glassy carbon electrode using voltammetric techniques. The dependence of current on potential, pH, concentrartion, scan rate, and excipients were investigated to optimize the experimental conditions. According to the liner relation between peak potential, peak current, scan rate and Pemetrexed disodium concentration, differential pulse voltammetric method for the quantitative determination in phosphate Buffer solution was developed. The linear response was obtained in the range of 10 µM to 0.75 µM with a detection limit of 0.19 µM. The electrochemical oxidation of mechanism of an anti-cancer drug Pemetrexed disodium was proposed.

 

Keywords- Pemetrexed disodium, Cyclic Voltammetry, Electochemical Studies, Glassy carbon electrode


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About this article

Title

ELECTROCHEMICAL OXIDATION AND DETERMINATION OF AN ANTI-CANCER DRUG PEMETREXED DISODIUM

DOI

10.22159/ajpcr.2017.v10i3.15941

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 492-496

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

118 Views | 29 Downloads

Authors & Affiliations

Nagaraj P Shetti
Visvesvaraya Technological University
India


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