• Sangeetha Raja Department of Pharmacology, SRM Medical College Hospital & Research Centre, Potheri-603203, Kancheepuram District, Tamilnadu, India.
  • Jamuna Rani R Department of Pharmacology, SRM Medical College Hospital & Research Centre, Potheri-603203, Kancheepuram District, Tamilnadu, India.
  • Kala P Department of Pharmacology, SRM Medical College Hospital & Research Centre, Potheri-603203, Kancheepuram District, Tamilnadu, India.


Objective: The aim of this study was to carry out adverse drug reactions (ADRs) monitoring in various departments of a tertiary care teaching hospital.
Methods: A cross-sectional study was conducted on ADRs reported in the hospital from December 2012 to May 2013 after obtaining Institutional
Ethics Committee approval.
Results: A total of 40 ADRs were reported, 47.50% were males and 52.50% were females. The female adult population was 45%. The majority of ADRs
were due to antimicrobial agents especially beta-lactam antibiotics (42.5%) followed by NSAIDs (7.50%). A maximum number of patients (75%)
were reported with dermatological manifestations. The department of medicine reported the highest number of ADRs (37.5%). As per Naranjo's
probability scale, 62.5% reports were assessed as probable. 62.5% reports were documented as mild according to Modified Hartwig's criteria for
severity assessment.
Conclusion: This study was done to sensitize the practicing physicians on the importance of adverse drug monitoring and reporting.
Keywords: Pharmacovigilance, Adverse drug reactions, Tertiary care teaching hospital, Antimicrobial agents.


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Table 1: Types of reactions for drugs in reported ADRs
Number of ADRs (%)
Ceftriaxone with sulbactam, Ceftriaxone, Ceftriaxone with tazobactam, Cefotaxime, Phenytoin, Ciprofloxacin, Cotrimoxazole, Metronidazole
20 (62.5)
Erythematous skin lesion
Diclofenac sodium, Cotrimoxazole, Paracetamol, Phenytoin, Carbamezapine, Clindamycin
6 (18.75)
Chest tightness and pain
Metronidazole, Iopamide
2 (6.25)
Throat irritation
1 (3)
Facial edema
1 (3)
1 (3)
Lip edema
1 (3)
ADRs: Adverse drug reactions
Table 2: List of organs system in ADRs
Organ system
Number of ADRs (%)
Gastrointestinal system
Cardiovascular system
Central nervous system
Eyes, ears, nose and throat
ADRs: Adverse drug reactions
Asian J Pharm Clin Res, Vol 10, Issue 3, 2017, 170-173
Raja et al.
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How to Cite
Raja, S., J. R. R, and K. P. “PATTERN OF ADVERSE DRUG REACTIONS IN A TERTIARY CARE TEACHING HOSPITAL: A CROSS-SECTIONAL STUDY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 3, Mar. 2017, pp. 170-3, doi:10.22159/ajpcr.2017.v10i3.15972.
Original Article(s)