• Sidharth Sraban Routray Department of anaesthesiology and critical care, SCB medical college,hospital. Cuttack, Odisha, India
  • Ramakanta Mohanty


Objective: During laparoscopic surgeries, pneumoperitoneum can lead to various pathophysiologic changes in the cardiovascular system resulting in
hypertension and tachycardia. Search for ideal drug to prevent this hemodynamic response goes on. The aim of our study was to evaluate the effect of
orally administered moxonidine in attenuating the hemodynamic responses that occur during the laparoscopic surgeries.
Methods: A total of 50 adult acetylsalicylic acid I and II patients scheduled for elective laparoscopic surgeries were selected for this prospective
randomized double-blinded study. They were randomly allocated into two groups: moxonidine group (M) and placebo group (P). M group received
oral moxonidine 0.3 mg at 8 pm on the day before surgery and at 8 am on the day of surgery. P group received a placebo at the same timing as that of
the M group.
Results: Following pneumoperitoneum rise in systolic blood pressure (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and heart rate (HR)
was higher in P group in comparison to M group which was statistically significant.
Conclusion: Significant rise in HR, SBP, DBP, and mean BP was noted in the P group in comparison to moxonidine group. Moxonidine provided better
perioperative hemodynamic stability in patients undergoing laparoscopic surgeries.
Keywords: Moxonidine, Stress response, Laparoscopic.


1. Marco AP, Yeo CJ, Rock P. Anesthesia for a patient undergoing laparoscopic cholecyctectomy. Anesthesiology 1990;73(6):1268-70.
2. Lindgren L, Koivusalo AM, Kellokumpu I. Conventional pneumoperitoneum compared with abdominal wall lift for laparoscopic cholecystectomy. Br J Anaesth 1995;75(5):567-72.
3. Gurusamy KS, Samraj K, Davidson BR. Abdominal lift for laparoscopic cholecystectomy. Cochrane Database Syst Rev 2008;8:CD006574.
4. Feig BW, Berger DH, Doughtery TB, Dupuis JF, Hsi B, Hickey RC, et al. Pharmacological interventions can reestablish baseline hemodynamic parameters during laparoscopy. Surgery 1994;116(4):733-9.
5. Joris J, Chiche JD, Lamy M. Clonidine reduced hemodynamic changes induced by pneumoperitoneum during laparoscopic cholecystectomy. Br J Anaesth 1995;74 Suppl: A124.
6. Aho M, Scheinin M, Lehtinen AM, Erkola O, Vuorinen J, Korttila K. Intramuscularly administered dexmedetomidine attenuates hemodynamic and stress hormone responses to gynecologic laparoscopy. Anesth Analg 1992;75(6):932-9.
7. Shribman AJ, Smith G, Achola KJ. Cardiovascular and catecholamine responses to laryngoscopy with and without tracheal intubation. Br J Anaesth 1987;59(3):295-9.
8. Saif GM, Singh V, Kumar A, Wahal R, Bhatia VK. A study of cardiovascular response during laryngoscopy and intubation and their attenuation by ultra-short acting beta-blocker esmolol. Indian J Anaesth 2002;46(2):104-6.
9. Farsang C. Moxonidine: Clinical profile. J Clin Basic Cardiol 2001;4(3):197-200.
10. Joris JL, Chiche JD, Canivet JL, Jacquet NJ, Legros JJ, Lamy ML. Hemodynamic changes induced by laparoscopy and their endocrine correlates: Effects of clonidine. J Am Coll Cardiol 1998;32(5):1389-96.
11. Koivusalo AM, Scheinin M, Tikkanen I, Yli-Suomu T, Ristkari S, Laakso J, et al. Effects of esmolol on hemodynamic responses to CO2 pneumoperitoneum for laparoscopic surgery. Acta Anaesthesiol Scand 2008;42(5):510-7.
12. Fenton C, Keating GM, Lyseng-Williamson KA. Moxonidine: A review of its use in essential hypertension. Drugs 2006;66(4):477-96.
13. Malek J, Knor J, Kurzova A, Lopourova M. Adverse hemodynamic changes during laparoscopic cholecystectomy and their possible suppression with clonidine premedication. Comparison with intravenous and intramuscular premedication. Rozhl Chir 1999;78(6):286-91.
14. Sung CS, Lin SH, Chan KH, Chang WK, Chow LH, Lee TY. Effect of oral clonidine premedication on perioperative hemodynamic response and postoperative analgesic requirement for patients undergoing laparoscopic cholecystectomy. Acta Anaesthesiol Sin 2000;38(1):23-9.
15. Das M, Ray M, Mukherjee G. Hemodynamic changes during laparoscopic cholecystectomy: Effect of oral clonidine premedication. Indian J Anaesth 2007;51(3):205-10.
16. Bansal T, Hooda S. Newer drugs in anaesthesia. Int J Pharm Pharm Sci 2012;4(1):668-70.
17. Banday M, Sameer A. Gabapentine: A pharmacotherapeutic Panacea. Int J Pharm Pharm Sci 2013;5(3):84-94.
225 Views | 341 Downloads
How to Cite
Routray, S. S., and R. Mohanty. “EFFECT OF ORAL MOXONIDINE IN THE ATTENUATION OF THE HAEMODYNAMIC RESPONSES SEEN DURING LAPAROSCOPIC SURGERIES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 3, Mar. 2017, pp. 409-11, doi:10.22159/ajpcr.2017.v10i3.16383.
Original Article(s)