EFFECT OF ORAL MOXONIDINE IN THE ATTENUATION OF THE HAEMODYNAMIC RESPONSES SEEN DURING LAPAROSCOPIC SURGERIES
Objective: During laparoscopic surgeries, pneumoperitoneum can lead to various pathophysiologic changes in the cardiovascular system resulting in
hypertension and tachycardia. Search for ideal drug to prevent this hemodynamic response goes on. The aim of our study was to evaluate the effect of
orally administered moxonidine in attenuating the hemodynamic responses that occur during the laparoscopic surgeries.
Methods: A total of 50 adult acetylsalicylic acid I and II patients scheduled for elective laparoscopic surgeries were selected for this prospective
randomized double-blinded study. They were randomly allocated into two groups: moxonidine group (M) and placebo group (P). M group received
oral moxonidine 0.3 mg at 8 pm on the day before surgery and at 8 am on the day of surgery. P group received a placebo at the same timing as that of
the M group.
Results: Following pneumoperitoneum rise in systolic blood pressure (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and heart rate (HR)
was higher in P group in comparison to M group which was statistically significant.
Conclusion: Significant rise in HR, SBP, DBP, and mean BP was noted in the P group in comparison to moxonidine group. Moxonidine provided better
perioperative hemodynamic stability in patients undergoing laparoscopic surgeries.
Keywords: Moxonidine, Stress response, Laparoscopic.
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