• Samran Amatrejo Faculty of Mathematics and Natural Science, University of Muslim Nusantara Al-Washliyah
  • Tanjung Hr Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Jl. Tridharma No. 5 Kampus USU, Medan, Indonesia



 Objective: Brotowali (Tinospora crispa) is well known as a bitter medicinal plant and traditionally has been used to treat rheumatism, gout, bruise, and fever and also to stimulate appetite. The bitter flavor of Tinospora extract has influenced the patient’s compliance in using the Tinospora extract, especially for the pediatric patients. Encapsulation was a coated process of drug using solid or liquid form of thin layer. The encapsulation process was used at the pharmaceutical and food industry to mask the bitter taste of product and protect the active ingredients from oxidation process. The study aims were to encapsulate the Tinospora extract with sodium alginate by drips method.

Methods: Brown algae (Sargassum ilicifolium) were a resource of alginate acid. Brown algae were macerate using HCl 5% to produced alginate acid, and sodium alginate was obtained by adding Na2CO3 5% to alginate acid solution. The study revealed that sodium alginate resulted from brown algae isolation process was 19.98% of the wet weight of brown algae. The formula of Tinospora extract microencapsulation was design into three formulas with different sodium alginate concentrations (F1=0.5%, F2=1%, and F3=1.5%).

Results: The microcapsule resulted from three formulas had the various weight of xerogel alginate but with similar diameter. Xerogel alginate weight of F1 was 1.98 g, F2 was 2.15 g, and F3 was 3.21 g. It can be concluded that the weight of xerogel alginate microcapsule and form of microcapsule were depended on the sodium alginate concentration.

Conclusions: The xerogel alginate microcapsule was evaluated for pre-formulation test, and the results showed that the microcapsule met the requirements of pre-formulations parameters without the adding of lubrication compound. The hedonic organoleptics test revealed that the microencapsulation process was able to cover the bitter taste and odor of Tinospora extract.

Keywords: Encapsulation, Xerogel alginate, Tinospora, Brown algae.


1. Rimelda N. Isolation and characterization of Na-alginate from brown algae (Sargassum plagyophyllum (Mertens) J.G. Agardh and the Effect of the Bleaching Composition Concentration on Viscosity. A Thesis. Medan: Universitas Sumatera Utara; 2013.
2. Agoes A. Indonesia’s Herbal Medicine. Jakarta Selatan: Salemba Medika; 2010. p. 15.
3. Basmal J, Yunizal J, Murtini T, Nasran S, Marsiana E, Abdulrokim I, et al. The Production of Alginate From Sargassum Seaweed. Jakarta Timur: Penebar Swadaya; 2013. p. 5, 9, 27.
4. Dalimartha S. The Prescription of Herbal Medicine for Uric Acid. Jakarta: Penebar Swadaya; 2008. p. 41-2.
5. Wilson N, Shah NP. Microencapsulation of vitamins. ASEAN Food J 2007;14(1):1-14.
6. Biswal I, Dinda A, Das D, Si S, Chowdary KA. Encapsulation protocol for highly hydrophilic drug using non-biodegradable polymer. Int J Pharm Pharm Sci 2011;3(2):256-9.
7. Yuliana S. Mikroencapsulation: Strategic Approach in food Fortification. Bogor: Balai Besar Penelitian dan Pengembangan Pascapanen Pertanian; 2011.
8. Yunizal. Extraction Technology of Alginate. Jakarta: Pusat Riset Pengolahan Produk dan Sosial Ekonomi Kelautan Dan Perikanan; 2004.
9. Budi K, Team L. Brotowali: Effication and Application. Jakarta: Agromedia Pustaka; 2003. p. 25-9.
10. Preeti K, Jathi K. Chitosan-sodium alginate biodegradable interpenetrating polymer network (IPN) beads for delivery of loxacin hydrochloride. Int J Pharm Pharm Sci 2010;2 Suppl 2:77-82.
11. Samran. Encapsulation and Released of Chloramphenicol From Gel of Alginat. A Thesis. Medan: Universitas Sumatera Utara Medan; 1992. p. 2-3.
12. Ansel HC. Pharmaceutical Dosage Form. Jakarta: UI Press; 2008.
13. Lachman L, Lieberman HA, Kanig Jl. Theory and Practice of Pharmaceutical Industry II. 3rd ed. Jakarta: Universitas Indonesia; 2008. p. 649-60, 886.
14. Soekarto SP, Soewarno T. Organoleptics Evaluation for Food and Farm Industry. Bogor: Pusbangtepa IPB-Press; 1981.
15. Yuan Z, Fei Y, Hong C, Jie Z, Jie M, Junhong C. Alginate/graphene double-network nanocomposite hydrogel beads with low-swelling, enhanced mechanical properties, and enhanced adsorption capacity. J Mater Chem A 2016;4:10885-92.
16. Mawaddana Q. Viability study of microencapsulation of Lactobacillus casei by Na-alginate matrix. Faculty of Medicine and Health. Pharmaceutical Department. Jakarta: UIN Syarif Hidayatullah; 2015.
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How to Cite
Amatrejo, S., and T. Hr. “TINOSPORA EXTRACT (TINOSPORA CRISPA (L.) MIERS.) ENCAPSULATION WITH SODIUM ALGINATE ISOLATED FROM BROWN ALGAE (SARGASSUM ILICIFOLIUM)”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 11, Nov. 2017, pp. 267-9, doi:10.22159/ajpcr.2017.v10i11.16517.
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