VALIDATION OF WATER PURIFICATION SYSTEM


N Vishal Gupta, Nataraj Hm, Ravi G

Abstract


Objective: Validation of water treatment systems is required to achieve water with all preferred quality attributes. This also delivers a circumstantial to establish a total control over the process which screens efficacy, safety, and ultimately, the process outcomes. The goal of steering validation is to establish that a process when operated within established limits, yields a product of reliable and definite quality with a high degree of assurance.

Methods: The current work is an effort to deliberate several aspects of validation comprising different approaches, machineries of water purification systems, equipment qualifications, performance testing phases, microbial and chemical analysis of water samples, documentation, and post-validation
monitoring. Mainly the validation is done for new water plants in pharmaceutical industry.

Results and Discussion: Sampling of water was carried out after each step in the purification process, and the results were found within limits.
Conclusion: Water purification systems must be operated in the interior regulatory guidelines as with pharmaceutical manufacture facilities.
Successful achievement of validation is confirmed by various testing phases. Usually, a three-phase testing approach is recommended over an extended
period to prove reliability and robustness of the system for producing water of specified quality with a high degree of assurance.

Keywords: Validation, Water purification systems, Quality attributes,Pharmaceutical manufacture facilities, Microbial and chemical analysis.


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References


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About this article

Title

VALIDATION OF WATER PURIFICATION SYSTEM

DOI

10.22159/ajpcr.2017.v10i4.16955

Date

01-04-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 4 April 2017 Page: 409-416

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

34 Views | 66 Downloads

Authors & Affiliations

N Vishal Gupta
Professor
India

Nataraj Hm

Ravi G


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