ASSOCIATION OF SERUM URIC ACID AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT DIABETIC RETINOPATHY


Ramesh Venkatachalam, Rathna Kumar, Ramachandran Kaliaperumal, Anitha Devaraj, Anebaracy V, Buvana Balamugundan, Poovitha R, Geetha Rajagopalan

Abstract


Objectives: Diabetic retinopathy (DR) is one of the microvascular complications in type 2 diabetes (T2D).  Elevated serum uric acid (SUA) has been shown to play a significant role in diabetic neuropathy and nephropathy but there is little information on retinopathy. Therefore, the present study was aimed to investigate the SUA and lipid profile in T2D patients with and without DR and the association between SUA and severity of DR.

Methods: The study was conducted in the ophthalmology OPD at Sri Lakshmi Narayana Institute of Medical Sciences. The presence of T2D was confirmed by investigating fasting blood glucose level (normal limit < 110 mg/dl) in all the individuals. DR was examined by detailed dilated fundoscopic examination. Based on the fundus examination, patients were divided in to diabetes with signs of DR and those without signs of DR. Age and sex matched healthy were taken as controls. Fasting blood sugar, SUA and lipid profile were investigated for these groups.

 Results: The study found elevated SUA and abnormal lipid profile in DR group when compared to non-DR and control groups. We also found the significant association between SUA and severity of DR particularly in males.

Conclusion: We found a significant association between SUA and severity of DR in T2D patients. Further studies with large sample size are needed to establish the role of elevated SUA and the mechanism involved in the pathogenesis of retinopathy in diabetic patients. Regular measurements of SUA level could be advised to the diabetic patients for the early management.


Keywords


Serum uric acid, Diabetic retinopathy, Lipid profile, Type 2 diabetes.

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About this article

Title

ASSOCIATION OF SERUM URIC ACID AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT DIABETIC RETINOPATHY

Keywords

Serum uric acid, Diabetic retinopathy, Lipid profile, Type 2 diabetes.

DOI

10.22159/ajpcr.2017.v10i6.17029

Date

01-06-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 6 June 2017 Page: 112-114

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

40 Views | 19 Downloads

Authors & Affiliations

Ramesh Venkatachalam
Department of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India.
India

Rathna Kumar
Department of Ophthalmology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India
India

Ramachandran Kaliaperumal
Department of Biochemistry, Mahatma Gandhi Medical College Hospital and Research Institute, Puducherry, India.
India

Anitha Devaraj
Department of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India
India

Anebaracy V
Department of Physiology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India.
India

Buvana Balamugundan
Department of Anatomy, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India.
India

Poovitha R
6Department of Community Medicine, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India.
India

Geetha Rajagopalan
Department of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India.
India


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