TURMERIC: NATUREâ€™S PRECIOUS MEDICINE.
Ethanobotany is a recent branch of natural science dealing with various aspects such as anthropology, archeology, botany, ecology, economics and medicine, religious, cultural and several other disciplines. Recently, great interest is given to studies of herbal drugs and traditional remedies are indicated worldwide and there has been an upsurge in the scientific investigations in area. Although turmeric (Curcuma longa and Curcuma aromatica Salisb.) has been described in Ayurveda, as treatment inflammatory diseases and is referred by different names in different cultures, active principle called Curcumin or diferuloylmethane, a yellow pigment present in turmeric (curry powder) has been shown to exhibit numerous activities. Extensive research over last fifty years has revealed several important functions of curcumin. The present study was aimed to review the ethanobotanical properties, pharmacognostic, phytochemical and pharmacological properties of turmeric plant. Root part of the plant are widely used by different tribal communities as turmeric have been shown to have wide spectrum of biological actions, which include anti-inflammatory, anti-diabetic, analgesic, antibacterial, anti-fungal, anti-protozoal, anti-ulcer, hypocholesteremic activities. Its anti-cancer effect induced mainly mediated through induction of apoptosis and many more medicinal values.
KEYWORDS: Curcuma aromatica Salisb. Ethanobotany, kasthuri turmeric, Pharmacognosy, Phytochemistry, Pharmacology.
2. Kojima H, Yanai T, Toyota A. Essential oil constituents from Japanese and Indian Curcuma aromatica rhizomes. Planta Medica 1998; 64: 380-381.
3. Pandey V, Kumar D. Biofertilizers for Sustainable Agriculture. Agric.Today 2002; 5:44-47.
4. Satishkumar B. Genetic Resources of Curcuma: Diversity characterization and utilization, Plant Genetic Research 2005; 3(2):230-251.
5. Skorniekova J, Sabu M, Prasanthkumar MG. Curcuma mutabilis (Zingiberaceae): a new species from South India, Gardensâ€™ Bull Singapore 2004; 56: 43-54.
6. Larsen K, Lock JM, Maas H, Maas PJM. Zingiberaceae. In: Kubitzki K, editors. The families and genera of vascular plants. Berlin: Springer- Verlag; 1998; 4: 474-495.
7. Sopher DE. Indigenous uses of turmeric (C. domestica) in Asia and Oceania. Anthropos 1964; 59: 93-127.
8. Nadkarni KM. Indian Materia Medica 1.3rd ed. Bombay: Popular Prakasan;1976.
9. Kirtikar KR, Basu BD. Indian Medicinal Plants. Dehra Dun, India: Bishensing Mahendrapal Singh, (Reprint);1984.
10. Duke JA. CRC Handbook of Medicinal Spices. Boca Raton: CRC Press; 2003.
11. Chang HM, But PP. Pharmacology and Applications of Chinese Materia Medica 1987; 2: 936-939.
12. Bensky D, Gamble A. Chinese Herbal Medicine Materia Medica. Seattle: East land press;1986. p.390-391.
13. Trishna D, Shanthi BM, Mrinmoy B, Mohanty JP, Shildibyendu. Evaluation of phytochemical screening and anti-fertility activity of curcuma aromatica salisb. (2010) International Journal of Pharmaceutical Sciences and research 2010; 1(1).
14. Ishita C, Kaushik B, Uday B, Ranajit KB. Turmeric and Curcumin: Biological actions and medical applications. Current sciences 2004; 87(1): 44-53.
15. Song EK. Diarylheptanoids with free radical scavenging and hepato protective activity in-vitro from Curcuma longs. Planta Med 2001; 67: 876- 877.
16. Kotwal GJ : Natural Products and Molecular Therapy. First International Conference, New York: Annal New York Acedamy of Sciences 2005; 1056.
17. Chattopadhyaya I, Biswas K, Bandopadhyay U, Banerjee, RK. Turmeric and curcumin: biological actions and medicinal applications. Current Science 2004; 87:44-53.
18. Omoloso AD, Vagi JK. Broad spectrum antibacterial activity of Allium cepa, Allium roseum, Trigonella foenum graecum and Curcuma domestica. Natural Product Sciences 2001; 7:13-16.
19. Negi PS, Jayaprakasha GK, Rao LJM, Sakariah KK. Antibacterial activity of turmeric oil: a byproduct from curcumin manufacture. J. Agricultural and Food Chemistry 1999; 47:4243-4297.
20. Dhar ML, Dhar MM, Dhavan BN, Mehrotra BN, Ray C. Screening of Indian plants for biological activity. Part 1 Ind. J. Exptl. Biol 1969; 6:232
21. Koide T, Nose M, Ogihara Y, Yabu Y, Ohta N. Leishmanicidal effect of curcumin in vitro. Biological & Pharmaceutical Bulletin 2002; 25:131-133.
22. Kuttan R, Bhanumati P, Nirmala K, George MC. Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett 1985; 29:197-202.
23. Kuo ML, Huang TS, Lin JK. Curcumin, an antioxidant and antitumor promoter, induces apoptosis in human leukemia cells. Biochim.Biophys. Acta 1996; 1317: 95-100.
24. Goel A, Boland CR, Chauhan DP. Specific inhibition of cyclooxygenase â€“2(COX-2) expression by dietary curcumin in HT 29 human colon cancer cells. Cancer Lett 2001; 172:111-118.
25. Shao ZM, Shen ZZ, Liu CH, Sartippour MR, Go VL, Hever D, et al. Curcumin exerts multiple suppressive effects on human breast carcinoma cells. Int.J.Cancer 2002; 98: 234â€“240.
26. Choudhari T, Pal S, Aggarwal ML, Das T, Sa G. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett 2002; 512:334-340.
27. Ammon HP, Wahl MA. Pharmacology of Curcuma longa, Planta Med; 1991, 57:1-7.
28. Ratul Kumar D, Naresh K, Utpal B. Encapsulation of Curcumin in alginate- chitosan- pluronic composite nanoparticles for delivery to cancer cells.Nanomedicine: NBM. 2010; 6: 153-160.
29. Gang R, Si-Shen F. Preparation and characterization of poly(lactic acid)-poly(ethylene glycol)- poly(lactic acid) (PLA-PEG-PLA) microspheres for controlled release of paclitaxel. Biomaterials 2003; 24 (27): 5037-5044.
30. Vijay Kumar M, Debasish S, Nayak PL. Chitosanâ€“sodium alginate anocomposites blended with cloisite 30b as a novel drug delivery system for anticancer drug curcumin. Int. J. Appl. Biol. Pharm. Technol. 2011; 2(3): 402-409.
31. Al-Hajj M, Becker MW, Wicha M, Weissman I, Clarke MF. Therapeutic implications of cancer stem cells. Curr Opin Genet Dev 2004; 14:43â€“7.
32. Lindvall C, Bu W, Williams BO, Li Y. Wnt signaling, stem cells, and the cellular origin of breast cancer. Stem Cell Rev 2010; 3:157â€“68.
33. Park CH, Hahm ER, Park S, Kim HK, Yang CH. The inhibitory mechanism of curcumin and its derivative against beta-catenin/Tcf signaling. FEBS Lett. 2005;579:2965â€“2971
34. Bachmeier B, Nerlich AG, Iancu CM, Cilli M, Schleicher E, Vene R et al. (1986) Chinese Herbal Medicine Materia Medica. Seattle: East land press; 1986. p390-391.
35. Sarma PV. Dravyaguna Vijnana, Varanasi, India (Reprint): Chaukhambha Bharati Academy; 2005.
36. Khare CP. Indian Herbal therapies. New Delhi: Vishv vijay Private Ltd; 2000.
37. Srimal RC, Khanna KM, Dhawan BN. A preliminary report on anti inflammatory activity of curcumin. Ind. J. Pharmacol 1971; 3: 10.
38. Chandra D, Gupta SS. Anti- inflammatory and anti-arthritic activity of volatile oil of Curcuma longa (Haldi) : Ind. J.Med.Res 1972; 60:131-142.
39. Deodhar SD, Sethi R, Srimal RC. Preliminary study on anti rheumatic activity of Curcumin (diferuloylmethane). Ind .J. Med Res 1980; 71: 632-634.
40. Remadevi R, Ravindran PN. Turmeric : Myths and Traditions. Spice India 2005. 18(8):11-17.
41. Joe B., Vijayakumar, M. and Lokesh B.R. (2004) Biological properties of Curcumin â€“cellular and molecular mechanisms of action. Critical Reviews in Food Science and Nutrition, 47, 97-111.
42. Khanna NM. Turmeric : Natureâ€™s Precious gift. Current Science 1999; 76:1351- 1356.
43. Rafatullah S. Medicinal, Aromatic and Poisonous Plants. Riyadh, Saudi Arabia: King Saud University; 1990.
44. Cohly HH, Rao P, Kanji MR, Manisundram VK, Taylor D, Wilson A, et al. Effect of turmeric (Chemical Plant Extract) on in-vitro nitric oxide synthetase (NOS) levels in tissues harvested from acute and chronic wounds. Wounds 1999;11(3):70-76.
45. Arun N, Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods for Human Nutri 2002; 57: 41-52.
46. Sajithlal GB, Chittra P, Chandrakesan G. Effect of Curcumin on the advanced glycation and cross-linking of collagen in diabetic rats. Biochem Pharmacol 1998; 56: 1607 â€“ 1614.
47. Kirtikar KR, Basu BD. Indian Medicinal Plants. Dehra Dun, India: Bishensing Mahendrapal Singh, (Reprint);1984.
48. Ram A, Das M, Ghosh B. Curcumin attenuates allergen induced airway hyperresponsiveness in sensitized guinea pigs. Biological & Pharmaceutical Bulletin 2003; 26: 1021-1024.
49. Kolammal M. Pharmacognosy of Ayurvedic Drugs. Trivandrum; Pharmacognosy unit, Govt Ayurveda College; 1979.
50. Anonymus. Wealth of India. National Institute of Science Communication, Council of Scientific & Industrial Research 2001.
51. Chopra RN, Chopra IC, Handa KL, Kapur LD. Indigenous Drugs of India. Calcutta: Academic Publishers; 1958.
52. Bhavanisankar TN, Srinivasa Murthy V. Effect of turmeric (Curcuma longa) fractions on the growth of some intestinal and pathogenic bacteria in vitro. Ind. J. Exp.Biol 1979; 17:1363-1366.
53. Patel K, Srinivasan K. Influence of dietary spices or their active principles on digestive enzymes of small intestinal mucosa in rats. Int. J.Food Sci.Nutr. 1996; 47: 55-59.
54. Lee CJ, Lee JH, Scok JH, Hur GM, Park YC, Scol IC, et al. Effects of baicalein, berberine, curcumin and hespiridin on mucin release from airway goblet cells. Planta Med 2003; 69:523-526.
55. Dasgupta SR, Sinha M, Sahana CC, Mukherjee BP. A study of the effect of an extract of Curcuma longa Linn. on experimental gastric ulcers in animals. Ind. J. Pharmacol 1969; 1:49-54.
56. Sinha M. Mukherjee BP, Muherjee B, Dasgupta SR. Study on the 5-hydroxytryptamine contents in guinea pig stomach with relation to phenylbutazone induced gastric ulcers and the effects of curcumin thereon. Indian J. Pharmacol 1974; 6: 87-96.
57. Gupta B, Kulsreshtha VK, Srivastava RK, Prasad DN. Mechanisms of curcumin induced gastric ulcer in rats. Indian J.Med.Res 1980; 71: 806-814.
58. Lal B, Kapoor AK, Asthana OP, Agrawal PK, Prasad R, Kumar P, et al. Efficacy of curcumin in the management of chronic anterior uveitis. Phytotherapy Research 1999; 13(4):318-322.
59. Halder N, Joshi S, Gupta SK. Lens aldose reductase inhibiting potential of some indigenous plants. J. Ethnopharmacology 2003; 86(1):113-116.
60. Kohli K, Ali J, Ansari MJ, Raheman Z. Curcumin: A natural anti-inflammatory agent. Indian Journal of Pharmacology 2005; 37 (3) :141-147.
61. Nair S, Rao MNA. Free radical scavenging activity of curcuminoids. Arzneimittel Forschung 1996; 46: 169-171.
62. Sang Hyun P, Kim GJ, Jeong, HS, Yum SK. Ar-turmerone and beta-atlantone induce internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia HL-60 cells. Archives of Pharmacal Research 1996; 19:91-94.
63. Bonte F, Noel-Hudson M.S, Wepierre J, Meybeck A. Protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress. Planta Medica 1997; 63:265-266.
64. Kawamori T, Lubet R, Steele VE, Kelloff GJ, Kaskey RB, Rao CV, et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Research (Baltimore) 1999; 59(3):597-601.
65. Khar A, Ali AM, Pardhasaradhi BVV, Begum Z, Rana Anjum R. Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells. FEBS Letters 1999; 445(1): 165-168.
66. Gupta B, Ghosh B. Curcuma longa inhibits TNF-alpha induced expression of adhesion molecules on human umbilical vein endothelial cells. International J. Immunopharmacology 1999; 21(11):745-757.
67. Ramsewak RS, DeWitt DL, Nair MG. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308.
68. Aggarwal BB, Kumar A, Bharti, AC. Anti-cancer potential of Curcumin: preclinical and clinical studies. Anticancer Research 2003; 231: 363-398.
69. Patil TN, Srinivasan M. Hypo cholesteremic effect of Curcumin in induced-hyper cholesteremic rats. Ind. J. Exp. Biol 1971; 9: 167-169.
70. Arafa HM. Curcumin attenuates diet-induced hypercholesterolemia in rats. Med. Sci. Monit 2005; 11(7): 228-234.
71. Garg SK, Mathur VS, Chaudhury RR. Screening of Indian plants for antiferility activity. Indian J.Exp.Biol 1978; 16:1077-1079.
72. Purohit A, Meenakshi B. Contraceptive effect of Curcuma longa (L.) in male albino rat. Asian J. Andrology 2004; 6: 71-74.
73. Madhuri K, Dean EB, Hasan K, Connie C, Karim T, Christophe G, et al. Targeting Breast Stem Cells with the Cancer Preventive Compounds Curcumin and Piperine. Breast cancer research treatment 2010;122(3):777-785.
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