PROGNOSIS IN ADVANCED NON-SMALL CELL LUNG CANCER - A RETROSPECTIVE STUDY EXAMINING ECOG PERFORMANCE STATUS SCORES OF PATIENTS


Nida Sajid Ali Bangash, Natasha Hashim, Nahlah Elkudssiah Ismail

Abstract


 

 Objective: Increasing prevalence and poor survival of advanced incurable non-small cell lung cancer (NSCLC) make it a major health problem globally, especially in developing countries. This awakens need for identification of the strongest prognostic factor that helps in the selection of appropriate treatment and hence palliates symptoms and improves survival. Lung cancer treatment guidelines advise performance status (PS) as the most established prognostic factor in advanced NSCLC patients. This study investigated the prognostic significance of PS.

Methods: An observational study was done for 163 advanced NSCLC adult Malaysian patients in Radiotherapy and Oncology Clinic, Hospital Kuala Lumpur, Malaysia. Demographic and clinical data were recorded. Kaplan-Meier test was used to measure median overall survival (OS) and Cox proportional hazard model to calculate the hazard ratio for different categories of Eastern Cooperative Oncology Group (ECOG) PS.

Results: The mean age and body weight were 56.7±10.1 years old and 57.42±13.5 kg, respectively. Majority patients were male (68.7%), Stage IV NSCLC (65.0%), and ECOG PS score of 2 (41.1%). ECOG PS had a significant association with age and body weight. Median OS was least for ECOG PS score of 4 (253 days) and was statistically significant (p=0.003). ECOG PS was a significant independent prognostic factor for survival in advanced NSCLC patients (p<0.001).

Conclusion: PS is a strong prognostic factor in advanced NSCLC.


Keywords


Performance status, Survival, Advanced non-small cell lung cancer.

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About this article

Title

PROGNOSIS IN ADVANCED NON-SMALL CELL LUNG CANCER - A RETROSPECTIVE STUDY EXAMINING ECOG PERFORMANCE STATUS SCORES OF PATIENTS

Keywords

Performance status, Survival, Advanced non-small cell lung cancer.

DOI

10.22159/ajpcr.2017.v10i9.17134

Date

01-09-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 9 September 2017 Page: 409-411

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Nida Sajid Ali Bangash
Department of Pharmacy, Clinical BioPharmaceutics Research Group, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
Malaysia

Natasha Hashim
Department of Oncology and Radiotherapy, Hospital Kuala Lumpur, 50300 Kuala Lumpur, Malaysia.
Malaysia

Nahlah Elkudssiah Ismail
Dean’s office, Faculty of Pharmacy, MAHSA University, Jalan SP2, Bandar Saujana Putra, 42610 Jenjarom Kuala Langat, Selangor.
Malaysia


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