GREEN SYNTHESIS, CHARACTERIZATION, AND ANTHELMINTHIC ACTIVITY OF NEWER QUINOLINE DERIVATIVES CONTAINING ACRIDINE MOIETY


Gollapalli Naga Raju

Abstract


 

 Objectives: Synthesis of newer 3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-9-(2-chloro-6-substituted-quinolin-3-yl)-acridine-1,8(2H,5H,9H,10H)-diones were synthesized by reacting 5,5-dimethylcyclohexane-1,3-dione with substituted 2-chloro-quinoline-3-carbaldehyde in presence of ammonium acetate.

Methods: Synthesis was carried out by microwave irradiation method and the synthesized compounds have been characterized using elemental analysis, FT-IR, 1H NMR, and 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and high-performance liquid chromatography technique. All the synthesized compounds were tested for antibacterial and anthelminthic activities.

Results: The results were revealed that the compounds AQ-4 and AQ-5 have showed good activity against both Gram-positive and Gram-negative bacteria. Compounds AQ-4 and AQ-5 showed moderate activity against all the organisms. However, all the derivatives have shown less antibacterial activity when compared to the standard drug amikacin. The compounds AQ-3 and AQ-5 showed good anthelminthic activity and compounds AQ-9 and AQ-10 showed moderate anthelminthic activity. However, all the compounds have shown less anthelmintic activity when compared to the standard drug albendazole.

Conclusion: The study reveals that compounds containing quinoline derivatives with acridine moiety shown the antibacterial activity against the pathogens Bacillus subtilis, Bacillus cereus, Staphylococcus epidermidis, Salmonella typhi, Pseudomonas aeruginosa and Klebsiella pneumoniae. These derivatives also possess the good anthelmintic activity. The above green synthesis technique could be a right solution for industrial applications in the future and therapeutic needs.


Keywords


Acridine, FT-IR, 1H NMR, Quinoline, Anthelminthic, Antibacterial.

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About this article

Title

GREEN SYNTHESIS, CHARACTERIZATION, AND ANTHELMINTHIC ACTIVITY OF NEWER QUINOLINE DERIVATIVES CONTAINING ACRIDINE MOIETY

Keywords

Acridine, FT-IR, 1H NMR, Quinoline, Anthelminthic, Antibacterial.

DOI

10.22159/ajpcr.2017.v10i9.17226

Date

01-09-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 9 September 2017 Page: 377-380

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Gollapalli Naga Raju
Department of Pharmaceutical Analysis including Chemistry, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India.
India


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