DEVELOPMENT OF FAST-DISSOLVING TABLETS OF AMLODIPINE BESYLATE BY SOLID DISPERSION TECHNOLOGY USING POLOXAMER 407 AND POLOXAMER 188


Manimaran V, Damodharan N

Abstract


Objective: Amlodipine besylate is a calcium channel blocker used in the treatment of hypertension which is practically insoluble in water. The present study aims to design oral fast-release tablets of amlodipine besylate and to optimize the dissolution of the drug by altering the carrier concentration.

Materials and Methods: Poloxamer 407 (P407) and poloxamer 188 (P188) were selected as carriers for the preparation of solid dispersion (SD) by the solvent evaporation method with different drug-polymer ratios. The prepared SDs were evaluated for the physical state, drug:carrier interactions by X-ray diffraction (XRD), infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy.

Results: From the dissolution studies, it is confirmed that all SDs showed increased dissolution rate when compared to pure amlodipine besylate. Among the two polymers used, P407 was found to be better than P188 in enhancing dissolution efficiency. The tablets were prepared using SD of amlodipine besylate containing P407 as a carrier. The results showed that P407 SD-based tablets gave a significantly higher release of amlodipine besylate when compared with control tablets. The infrared spectral studies showed that there was no significant interaction between amlodipine besylate and its formulation with different polymers used in the preparation of SDs. XRD studies revealed that the degree of crystallinity of amlodipine besylate reduced when the concentration of carriers increased, which reveals that the drug is in amorphous nature.

Conclusion: The combination of SD technology and using superdisintegrants in the formulation is a promising approach for preparing efficient, fast-dissolving tablet of poorly water-soluble drugs, viz., amlodipine besylate.


Keywords


Amlodipine besylate, Calcium channel blocker, Fast-dissolving tablets, Poloxamer 407, Poloxamer 188, Solid dispersion, Superdisintergrants.

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About this article

Title

DEVELOPMENT OF FAST-DISSOLVING TABLETS OF AMLODIPINE BESYLATE BY SOLID DISPERSION TECHNOLOGY USING POLOXAMER 407 AND POLOXAMER 188

Keywords

Amlodipine besylate, Calcium channel blocker, Fast-dissolving tablets, Poloxamer 407, Poloxamer 188, Solid dispersion, Superdisintergrants.

DOI

10.22159/ajpcr.2017.v10i7.17686

Date

01-07-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 7 July 2017 Page: 135-141

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

176 Views | 143 Downloads

Authors & Affiliations

Manimaran V
Department of Pharmaceutics, SRM College of Pharmacy, SRM University, Kattangulathur - 603 203, Chennai, Tamil Nadu, India.
India

Damodharan N
Department of Pharmaceutics, SRM College of Pharmacy, SRM University, Kattangulathur - 603 203, Chennai, Tamil Nadu, India.
India


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