A CASE REPORT ON CHRONIC LEAD POISONING FROM OCCUPATIONAL EXPOSURE

Authors

  • Nazma M Department of Pharmacy Practice, Sri Venkateswara College of Pharmacy, Chittoor - 517 127, Andhra Pradesh, India.
  • Dhivya K Department of Pharmacy Practice, Sri Venkateswara College of Pharmacy, Chittoor - 517 127, Andhra Pradesh, India.
  • GNANA CHAITANYA C
  • Divya Sree P Department of Pharmacy Practice, Sri Venkateswara College of Pharmacy, Chittoor - 517 127, Andhra Pradesh, India.
  • Lakshmi Prasanna S Department of Pharmacy Practice, Sri Venkateswara College of Pharmacy, Chittoor - 517 127, Andhra Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i6.18061

Keywords:

Lead poisoning, Kidney damage, Chelating agents, Industrial workers

Abstract

The hazard to public health from lead continues to be a matter of concern. It is one of the most serious environmental poisons among the toxic heavy metals all over the world. Lead poisoning is seen in all age groups, especially in adults working in lead-based industries. We report the case of a 28-year-old man working in an unorganized lead-based manufacturing unit admitted with the complaints of giddiness, excessive tiredness, pain in the upper abdomen, decreased appetite, excessive body pains, increased sweating, and oliguria. Investigations carried out during the admission showed hemoglobin levels of 8.5 g/dl and blood lead level (BLL) of 115 μg/dl. The patient was subjected to chelation therapy. After repeated course of chelation therapy, he has shown the signs of improvement. The paucity of a safe workplace and awareness among workers results in high BLLs. Therefore, education and awareness related to lead hazards is considered necessary.

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References

Carocci A, Catalano A, Lauria G, Sinicropi MS, Genchi G. Lead toxicity, antioxidant defense and environment. Rev Environ Contam Toxicol 2016;238:45-67.

Flora G, Gupta D, Tiwari A. Toxicity of lead: A review with recent updates. Interdiscip Toxicol 2012;5(2):47-58.

Gupta S, Manoj KR, Meena SD. Effect of selected heavy metals (lead and zinc) on seedling growth of soybean glycine max (L.) Merr. Int J Pharm Pharm Sci 2016;8(8):302-5.

Amol SK, Amit RN, Anurag GP, Anita S, Vinod G. Lead poisoning: An overlooked diagnosis in clinical practice. Int J Res Ayurveda Pharm 2012;3(5):639-44.

Papanikolaou NC, Hatzidaki EG, Belivanis S, Tzanakakis GN, Tsatsakis AM. Lead toxicity update. A brief review. Med Sci Monit 2005;11(10):RA329-36.

Woolf AD, Goldman R, Bellinger DC. Update on the clinical management of childhood lead poisoning. Pediatr Clin North Am 2007;54(2):271-94, viii.

Rastogi SK.Renal effects of environmental and occupational lead exposure. Indian J Occup Environ Med 2008;12(3):103-6.

Prashant A, Anitgya M, Kumar M, Tripathi SK. A comprehensive review of environmental exposure of lead and its toxicity. J Indian Forensic Med 2009;31(3):299-303.

Gordon JN, Taylor A, Bennett PN. Lead poisoning: Case studies. Br J Clin Pharmacol 2002;53(5):451-8.

Grandjean P, Jørgensen PJ, Viskum S. Temporal and interindividual variation in erythrocyte zinc-protoporphyrin in lead exposed workers. Br J Ind Med 1991;48(4):254-7.

Bergdahl IA, Grubb A, Schütz A, Desnick RJ, Wetmur JG, Sassa S, et al. Lead binding to delta-aminolevulinic acid dehydratase (ALAD) in human erythrocytes. Pharmacol Toxicol 1997;81(4):153-8.

Kimberlie A, Graeme MD, Charles VP. Heavy metal toxicity, part II: Lead and metal fume fever. J Emerg Med 1998;16(2):171-7.

Goldberg A. Lead poisoning and haem biosynthesis. Br J Haematol 1972;23(5):521-4.

Thenmozhi M, Dhanalakshmi M, Devi KM, Sushila K, Thenmozhi S. Evaluation of hepatoprotective activity of Leucas aspera hydroalcoholic leaf extract during exposure to lead acetate in male albino wistar rats. Asian J Pharm Clin Res 2013;6:78-81.

Schütz A, Skerfving S, Christoffersson JO, Tell I. Chelatable lead versus lead in human trabecular and compact bone. Sci Total Environ 1987;61:201-9.

Published

01-06-2017

How to Cite

M, N., D. K, GNANA CHAITANYA C, D. S. P, and L. P. S. “A CASE REPORT ON CHRONIC LEAD POISONING FROM OCCUPATIONAL EXPOSURE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 6, June 2017, pp. 1-2, doi:10.22159/ajpcr.2017.v10i6.18061.

Issue

Section

Case Study(s)