HAEMOSTATIC EFFECT OF ETHANOLIC EXTRACT OF Ageratum conyzoides L TO STRAINS OF MICE MALE SWISS WEBSTER INDUCED WITH COMBINATION OF ASPIRIN, CLOPIDOGREL AND ENOXAPARIN


Yedy Purwandi Sukmawan, Hendy Suhendy

Abstract


Objective: Bleeding complications are a common concern with the use of combination of antiagregations and anticoagulant agents especially on acute coronary syndrome treatment. In selected situations such as life-threatening, reversing may be desired, but no specific antidotum for the newer agents such as enoxaparin, fondaparinux, levirudin, bivalirudin, and argatroban. Ageratum conyzoides L is a medicinal plants that have a hemostatic effect. The objective of the study is to know the hemostatic effect of A. conyzoides L to induction of acetosal, clopidogrel, and enoxaparin.

Methods: A total of 20 mice are divided into five groups that are normal, negative, positive, Test I and II. There were no treatment for normal, induction of drugs combination for negative, induction of drugs combination and tranexamic acid for positive, induction of drugs combination and ethanolic extract of A. conyzoides L (100 mg/Kg BW) for Test I, induction of drugs combination and ethanolic extract of A. conyzoides L (250 mg/Kg BW) for Test II.

Results: The Test Groups I and II showed reversing of clotting time to normal baseline and shown a significant difference (p<0.05) compared with the negative group. In addition, the Test Groups I and II showed significant difference (p<0.05) of bleeding time compared with the negative group and the Test II (250 mg/Kg BW) shown reversing of bleeding time to normal baseline.

Conclusion: The hemostatic effect showed by ethanolic extract of A. conyzoides L to induction of combination acetosal, clopidogrel and enoxaparin are very valuable for reversing agent novel.


Keywords


Bleeding, Reversing, Hemostatic, Ageratum conyzoides L.

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About this article

Title

HAEMOSTATIC EFFECT OF ETHANOLIC EXTRACT OF Ageratum conyzoides L TO STRAINS OF MICE MALE SWISS WEBSTER INDUCED WITH COMBINATION OF ASPIRIN, CLOPIDOGREL AND ENOXAPARIN

Keywords

Bleeding, Reversing, Hemostatic, Ageratum conyzoides L.

DOI

10.22159/ajpcr.2017.v10i7.18573

Date

01-07-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 7 July 2017 Page: 276-279

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

285 Views | 116 Downloads

Authors & Affiliations

Yedy Purwandi Sukmawan
Department of Pharmacology and Clinical Pharmacy, Program Study of Pharmacy, Institute of Health Science Bakti Tunas Husada, Tasikmalaya, West Java, Indonesia.
Indonesia

Hendy Suhendy
Department of Pharmacognosy, Program Study of Pharmacy, Institute of Health Science Bakti Tunas Husada, Tasikmalaya, West Java, Indonesia.
Indonesia


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