THE ROLE OF ACALYPHA INDICA LINN. EXTRACT ON HEART RATES WITH MYASTHENIA GRAVIS RAT MODEL


Desak Gede Budi Krisnamurti, Rani Wardani Hakim, Radiana Dhewayani Antarianto, Siti Farida, Erni Hernawati Purwaningsih, Jan Sudir Purba

Abstract


 

 Objective: Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) caused by antibodies that attack components of the postsynaptic membrane, impair neuromuscular transmission, and lead to weakness and fatigue of skeletal muscle. Acetylcholine is also used as a neurotransmitter in the autonomic nervous system. Striated cardiac muscle can be a target for immune attack manifesting as heart failure, arrhythmia, and sudden death. Involvement of the heart rate (HR) has been claimed and reported, but a causal connection between MG and altered cardiac function has not been found.

Methods: For this study of experimental autoimmune MG (EAMG) is used rocuronium, prostigmine, and Acalypha indica (AI) Linn. compared with HR.

Results: From the results, the study found that sympathetic activity of HR variability in EAMG injected with rocuronium 10 mg/kg body weight (BW) in 10 min significantly found increasing in measures of short-term variations in HR variability, indicating parasympathetic impairment.

Conclusion: We conclude that in MG, cholinergic transmission is affected more diffusely than previously thought. Furthermore, AI was given orally 30 mg/kg BW has an effect similar to the injecting of prostigmine 10 mg/kg BW that can reduce HR. Driven by the fact that the pharmacological treatment of MG is unsatisfied, it needs the therapeutic development for MG using herbal ingredients of AI. This means that the AI compositions containing anti-MG whose composition should be investigated for the next research.


Keywords


Myasthenia gravis, Extract Acalypha indica Linn., Acetylcholine receptor antibody, Autoimmune disease, Neuromuscular junction, Heart rate.

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About this article

Title

THE ROLE OF ACALYPHA INDICA LINN. EXTRACT ON HEART RATES WITH MYASTHENIA GRAVIS RAT MODEL

Keywords

Myasthenia gravis, Extract Acalypha indica Linn., Acetylcholine receptor antibody, Autoimmune disease, Neuromuscular junction, Heart rate.

DOI

10.22159/ajpcr.2018.v11i1.18616

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 257-260

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

108 Views | 136 Downloads

Authors & Affiliations

Desak Gede Budi Krisnamurti
Department of Neurology, Dr. Ciptomangunkusumo, General Hospital Faculty of medicine, Universitas Indonesia
Indonesia

Rani Wardani Hakim
Department of Neurology, Dr. Ciptomangunkusumo, General Hospital Faculty of medicine, Universitas Indonesia
India

Radiana Dhewayani Antarianto
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Indonesia

Siti Farida
Department of Neurology, Dr. Ciptomangunkusumo, General Hospital Faculty of medicine, Universitas Indonesia
Indonesia

Erni Hernawati Purwaningsih
Department of Neurology, Dr. Ciptomangunkusumo, General Hospital Faculty of medicine, Universitas Indonesia
Indonesia

Jan Sudir Purba
Department of Neurology, Universitas Indonesia, Jakarta, Indonesia.
Indonesia


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