COST-EFFECTIVENESS ANALYSIS OF INSULIN REGIMEN ON TYPE 2 DIABETES MELLITUS OUTPATIENT IN DENPASAR MUNICIPALITY


Luh Putu Febryana Larasanty, Made Ary Sarasmita, I Gusti Ngurah Agung Dewantara Putra

Abstract


Objective: Insulin is one of the antidiabetic agents that available for the treatment of type 2 diabetes mellitus (T2DM) patients. Insulin has several types of formulation, with its cost and effectiveness. The aim of this study was to compare the cost-effectiveness of insulin regimen in the therapy management of T2DM outpatient.

Methods: Cost-effectiveness analysis has been done by calculating the average cost-effectiveness ratio (ACER) and incremental cost-effectiveness ratio (ICER) of each insulin regimens. Effectiveness was measured by improvement of fasting blood glucose, postprandial blood glucose, and HbA1c value. The total cost of insulin regimen was calculated from direct medical cost, direct nonmedical cost, and indirect nonmedical cost.

Results: Overall, 42 patients meet the inclusion criteria were included this study. There were four insulin regimens compared, namely, insulin detemir,premixed insulin aspart, insulin aspart, and a combination of insulin aspart + insulin glargine. The combination of insulin aspart + insulin glargine provides pre-eminent therapy effectiveness (58.82%), whereas insulin detemir regimen has the lowest total cost (102.62 USD). Calculation of ACER showed that insulin aspart has the lowest ACER value, in an amount of 1.91 USD per percentage of effectiveness. Based on ICER value, insulin aspart was the better choice compared to the combination of insulin aspart + insulin glargine (0.18 USD vs. 0.82 USD).

Conclusion: The variation of therapeutic effectiveness and total cost was observed in the management of T2DM outpatient. Based on ACER and ICER value, insulin aspart was the most cost-effective insulin compared to another insulin regimen on the study.


Keywords


Average cost-effectiveness ratio, Cost-effectiveness analysis, Incremental cost-effectiveness ratio, Insulin, Type 2 diabetes mellitus

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About this article

Title

COST-EFFECTIVENESS ANALYSIS OF INSULIN REGIMEN ON TYPE 2 DIABETES MELLITUS OUTPATIENT IN DENPASAR MUNICIPALITY

Keywords

Average cost-effectiveness ratio, Cost-effectiveness analysis, Incremental cost-effectiveness ratio, Insulin, Type 2 diabetes mellitus

DOI

10.22159/ajpcr.2018.v11i1.18695

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 89-92

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

28 Views | 64 Downloads

Authors & Affiliations

Luh Putu Febryana Larasanty
Department of Pharmacy, Faculty of Mathematics and Basic Science, Udayana University, Bali, Indonesia.
Indonesia

Made Ary Sarasmita
Department of Pharmacy, Faculty of Mathematics and Basic Science, Udayana University, Bali, Indonesia.
Indonesia

I Gusti Ngurah Agung Dewantara Putra
Department of Pharmacy, Faculty of Mathematics and Basic Science, Udayana University, Bali, Indonesia.
Indonesia


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